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  •  
    1.635,95 kr.

    Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

  •  
    1.635,95 kr.

    Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book''s chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality.Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer researchOffers outstanding and original reviews on colorectal cancer researchProvides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer

  •  
    1.637,95 kr.

    Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more.Addresses the relationship between autophagy and senescence in cancer therapyCovers autophagy and senescence in tumor dormancyExplores autophagy and senescence in disease recurrence

  • af George Klein & George F. Vande Woude
    1.466,95 kr.

    Provides information on the field of cancer research. The key features of this work include: The Yin Yang of TCF/b-Catenin Signalling; Biochemical and Clinical Implications of the Erb/HER Signaling Network of Growth Factor Receptors; p53 and Human Cancer: The First Ten Thousand Mutations; Macrophage Stimulating Protein; and more.

  •  
    1.635,95 kr.

    GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more. G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics. Covers the latest concepts in GPCR signaling and their relevancy to cancer biologyPresents new indications for anti-cancer therapeutic programsIncludes sections on cross-talk and signaling networks of GPCRs and effectors in molecular oncology and therapeutics

  •  
    1.590,95 kr.

  •  
    1.635,95 kr.

    Advances in Cancer Research, Volume 144, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research. Chapters in this new release include Gene-Environment-Microenvironment Interactions in Melanomagenesis, PP2A and the Cell Cycle, Current Progress Defining Calcium Signals as Therapeutic Targets in Cancer Cells, and much more. Provides the latest information on cancer researchOffers outstanding and original reviews on a range of cancer research topicsServes as an indispensable reference for researchers and students alike

  •  
    1.635,95 kr.

  •  
    1.673,95 kr.

  •  
    1.275,95 kr.

    Cancer Disparities, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This latest volume presents a broad introduction to a spectrum of factors contributing to cancer disparities that include ancestral informative markers'' role in properly identifying race based on genetic ancestry, basic biological pathways contributing to cancer disparities, epidemiological factors linked to cancer disparities, and social/behavioral factors influencing cancer disparities.Describes the complex interplay of contributors to cancer disparities, ranging from the micro to macro level, and based on the social, environmental, and biological determinants of healthProvides a range of chapters reflecting the unique expertise of the authors in these diverse topic areas

  •  
    1.275,95 kr.

    Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer.Provides information on cancer researchOffers outstanding and original reviews on a range of cancer research topicsServes as an indispensable reference for researchers and students alike

  •  
    1.264,95 kr.

    Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis.Presents groundbreaking information on the molecular and cellular basis of metastasisProvides information on cancer researchOutstanding and original reviewsSuitable for both researchers and students

  •  
    1.911,95 kr.

    Provides information on the field of cancer research. This title presents reviews on a variety of topics.

  •  
    1.549,95 kr.

    This series provides coverage of all aspects of the molecular basis of human cancer, functions of oncogenes, and research strategies for cancer drug development and treatment. This volume includes a chapter on effectors of signal transduction and GI progression,

  •  
    1.549,95 kr.

    This text discusses the roles of p53 and ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to improved cancer therapies. Other areas of study covered include the methodological advantages and limitations to localizing tumour suppressor genes.

  • - Cumulative Subject Index
     
    1.549,95 kr.

    This volume comprises the cumulative subject index covering volumes 50-72 of the series "Advances in Cancer Research". It includes references to specific articles on topics such as breast cancer, prostrate cancer, Kaposi's sarcoma, Burkitt's lymphoma, leukemias, oncogenes and tumour genetics.

  • af Wang & Fisher
    1.621,95 kr.

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