Bøger af Erina Jimenez

Extracellular vesicles (EVs) are lipid bilayer-delimited particles which are released naturally from nearly all types of cells but cannot replicate like cells. There are three types of EVs that are categorized on the basis of their size and synthesis route. These include apoptotic bodies, exosomes, and microvesicles. They transport a cargo of lipids, proteins, metabolites, nucleic acids and even parent cell organelles. The communication mechanism among cells relies heavily on EVs. They are also capable of carrying disease biomarkers, including CD24, glypican-1, CD63, and colon cancer-associated transcript 2 (CCAT2). Current research around EVs focuses on their role in various diseases and conditions such as cancer, neurodegeneration, metabolic disorders, and intercellular communication. Owing to their cargo delivery potential, EVs may be used as drug delivery platforms for cancer therapy. Furthermore, engineered EVs may find application in cancer combination therapy. This book explores the new frontiers in the study of extracellular vesicles. It is appropriate for students seeking detailed information on extracellular vesicles, as well as for experts.

Extracellular vesicles (EVs) are elements enfolded in a lipid bilayer membrane. Similar to exosomes, they are released by all living cells. They comprise a variety of bioactive molecules such as lipids, nucleic acids, metabolites and proteins. EVs have potential as a target for liquid biopsies because they can be detected in nearly all types of body fluids, including breast milk, blood, saliva, ascites and urine. Tumor-secreted EVs are important mediators for intercellular communication in both local and remote microenvironments. They are naturally taken up by the target cells and could be utilized to transfer therapeutic agents. It is crucial to recognize EV subtypes in order to determine which pathways are influenced by EVs and which subtypes can be targeted in liquid biopsies or therapeutic methods. This book provides comprehensive insights on extracellular vesicles. It is compiled in such a manner, that it will provide an in-depth knowledge about the role of extracellular vesicles in human health. This book will serve as a reference to a broad spectrum of readers.