Bøger i Biophysical Society-IOP Series serien

Anyoneteaching physical biochemistry or structural biology will find this to be aconcise and thorough guide for their lectures on protein-protein association.Students and researchers will appreciate the clarity of presentation offundamental concepts, and the guided reading of informative classic papers.

This book offers a complete presentation of the physics, math, and experimental setups for both TIRF and related evanescence microscopies, for both excitation or emission. It also discusses combinations of evanescence microscopies with numerous other microscopy techniques.

This book discusses the cellular and molecular basis for the regulation of calcium changes in cells and, in turn, the impact of changes in cell calcium on physiological function.

Physics of Cancer focuses on the mechanical properties of cancer cells and their role in cancer disease and metastasis. It discusses the role of the mechanical properties of interacting cells and the connective tissue microenvironment and describes the role of an inflammation during cancer disease. This outstanding book is the first to describe cancer disease from a biophysical point of view without being incomplete in describing the biological site of cancer. Originating in part from the author's own courses on tumor biology and cellular biophysics, this book is suitable for both students and researchers in this dynamic interdisciplinary field, be they from a physical, biological or medical sciences background.

This edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. It is especially well suited for larger complexes and molecular machines. This book, provides a comprehensive, accessible and authoritative introduction to the field. It covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of results.Key featuresWritten for students, postdocs and established investigators who want to enter the field of single-particle cryo-EMProvides a comprehensive, accessible and authoritative introduction to the field of high-resolution structure analysis by single-article cryo-EMCovers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data-collection, data analysis, and the final validation of resultsAuthors of individual sections of this book have been recruited from among the most authoritative leaders in each topic

Diabetes Systems Biology provides senior undergraduate students and junior scientists, interested in diabetes systems biology, with a tool to learn more about the mathematical models and methods used to understand macroscopically and microscopically beta-cell behaviour in health and disease. The book introduces readers to the quantitative methods used to examine beta-cell dynamics, islet biology and architecture, as well as diabetes etiology and implications. The goal is to allow junior researchers in the fields of mathematical biology and biophysics to obtain a broad understanding of these quantitative methods, and guide them into taking the first steps into the field of diabetes systems biology. At the end of each chapter, several problem-solving exercises (that require both analytical and computational skills) are provided for the readers to help them become more proficient in this field.Key FeaturesComprehensive overview of all relevant aspects of diabetes systems biology and biological mathematical modellingCovers quantitative aspects of this discipline with embedded examplesFeatures contributions from world-class researchers in the fieldProvides extensive references for further readingIncludes problem solving exercises at the end of each chapter

This book describes the methodology and applications of solid-state NMR spectroscopy to studies of membrane proteins, membrane-active peptides and model biological membranes. As well as structural studies it contains coverage of membrane interactions and molecular motions. Advances in biological solid-state NMR are very pertinent with high-field developments seeing applications in biological membranes and whole cells. Many of the chapter authors and contributors are world-class experts and leaders in the development and application of biological solid-state NMR. Key Features Addresses principles, methods and applications of solid-state NMR methods to biomembrane studiesIntroduction to biological solid-state NMR and applications to biological membranesStructure and dynamics of membrane lipids, proteins and peptidesNMR studies of membrane interactions and molecular motion

This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models.

An Introduction to Fluorescence Correlation Spectroscopy represents a comprehensive introduction to fluorescence correlation spectroscopy (FCS), a biophysical experimental technique increasingly used to study and quantify molecular mobility, concentrations and interactions in vitro, as well as in living cells and multicellular organisms. Students and researchers who are new to FCS can use the book as the first introduction to the technique, while those who are already using FCS regularly in their research may find it useful to deepen their understanding of the technique, its possibilities, limitations, and potential pitfalls as well as ways to avoid them. This book introduces the reader to all aspects of FCS needed for practical usage of the technique in their research. In the beginning the concept of fluorescence intensity fluctuations and their auto- and cross-correlation functions are explained to give readers an understanding of the underlying principles. This is followed by an overview of instrumental FCS setups and various ways of data collection and processing, the derivations of theoretical models relating the experimentally obtained correlation functions to the underlying molecular processes, and the description of the fitting of experimental data with those models. Mathematically more involved portions are separated from the rest of the text and can be easily skipped by readers more interested in the conceptual and practical aspects of FCS. The book contains interactive graphics and is accompanied by an interactive computable document file allowing the reader to test the dependence of FCS results on a variety of experimental parameters, and to gain practical insights into FCS data fitting.Key FeaturesIntroduces the concepts of FCS in an accessible way, supported by animations and graphics in the ebook.Includes a supplementary interactive computable document file that allows the reader to experiment with various FCS setup and fit parameters, allowing readers to test their understanding and simulate experimental outcomes.Provides rigorous mathematical derivations of fundamental FCS equations and models.Pedagogical features include questions, short reviews and critical discussions of literature relevant to the particular chapter that include applications and fundamental developments in the field of FCS.

Biophysical and Chemical Properties of Collagen: Biomedical Applications provides an introduction to the biophysics and chemistry of collagen and its use as a biomedical material in the rapidly changing fields of biomedical device production, tissue engineering and regenerative medicine. Written by experts in the field, this text will be of interest for researchers as well as lecturers and students.

This revised second edition isimproved linguistically with multiple increases of the number of figures andthe inclusion of several novel chapters such as actin filaments during matrixinvasion, microtubuli during migration and matrix invasion, nucleardeformability during migration and matrix invasion, and the active role of thetumor stroma in regulating cell invasion.

This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.