Bøger i Chromatographic Science Series serien

Organized by two leaders in the field, this text establishes a sound fundamental basis for the principles of the two-dimensional liquid chromatography technique, followed by a discussion of important practical considerations.

This book provides a comprehensive source of knowledge of new sorbent materials, presenting fundamental principles for their syntheses, and adsorption properties. It presents advanced techniques employed to create specialized sorbents with a wide range of functions, which can be used to enhance the separation and/or purification of useful bioact

Chirality plays a major role in biological processes and the enantiomers of a bioactive molecule often possess different biological effects. Accurate assessment is critical as isomeric impurities may have unwanted toxicological, pharmacological, or other effects. Separation techniques remain the method of choice for this area of drug research but there is a great deal of trial and error in choosing a particular column for a chiral separation. This book gives a rationale for choosing a stationary phase that is based on the relationship that exists between the analytes and the chiral stationary phases. The text provides examples to underline the separation mechanism.

This book discusses flow perturbation method, namely, the stopped-flow technique and the reversed-flow technique. It is directed to those who need an accurate method for the determination of a certain physicochemical quantity and to researchers working on the development of gas chromatography.

This book describes the various aspects of microbore column chromatography. It provides readers with an in-depth understanding of the supercritical fluid chromatography and microbore high-performance liquid chromatography.

Focusing on recent developments in microfluidic lab-on-a-chip technologies, this book offers an overview of the limitations and breakthroughs of this technology over the years. The author emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separat

Preparative Layer Chromatography explains how this method is used for separating large quantities of mixtures containing a wide variety of important compounds. It offers a broad review of preparative layer chromatography (PLC) applications and adaptable working procedures for microseparations involving organic, inorganic, and organometallic compoun

Offering well-rounded coverage of the most significant technological developments in the past few years, this classic work explains how to use LC-MS technology and interpret LC-MS data for various disciplines. This edition places a stronger emphasis on applications, dedicating more than two-thirds of the text to examining LC-MS in emerging areas

Worldwide experts in thin layer chromatography (TLC) applications in diverse fields discuss the separation, identification, quantification, and isolation of medicinal plant components. Part I offers a current overview of TLC and phytochemistry. Part II emphasizes real strategies and procedures for analyzing all types of primary and secondary pla

Now in its second edition, this updated text examines new advances and concepts in the field. Topics include monolithic columns, bonded stationary phases, micro-HPLC, two-dimensional comprehensive liquid chromatography, gradient elution mode, retention models for ions, and capillary electromigration techniques. It addresses HPLC detectors, LC-MS

An up-to-date, complete reference, this book covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. Part I is devoted to gener

This book serves as a comprehensive source of information and training on the state-of-the-art pesticide residues methods performed with aid of HPLC and aids the readers in avoiding the many pitfalls that are possible during work with the HPLC mode

This book focuses on a relatively new approach to chemical analysis in general, and to separation science in particular. It is the first book to systemically cover the theoretical background, techniques, instrumentation, and practical applications of planar chromatography - mass spectrometry as a hyphenated tool of analytical chemistry. It also

This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials.

An up-to-date reference that presents the most important information about each area of chemometrics used in chromatography, demonstrating its effective use when applied to a chromatographic separation.

Xenobiotics are chemical compounds foreign to a given biological system. This reference will help the analyst develop effective and validated analytical strategies for the analysis of hundreds of different xenobiotics on hundreds of different sample types, quickly, accurately and at acceptable cost.

This detailed handbook covers different chromatographic analysis techniques and chromatographic data for compounds found in air, water, soil, and sludge. The new edition outlines developments relevant to environmental analysis, especially when using chromatographic mass spectrometric techniques. It addresses new issues, new lines of discussion,

Xenobiotics are chemical compounds foreign to a given biological system. This reference will help the analyst develop effective and validated analytical strategies for the analysis of hundreds of different xenobiotics on hundreds of different sample types, quickly, accurately and at acceptable cost.

Reviews the use of surfactant solutions at or above the critical micelle concentration as mobile phases in liquid chromatography. This title employs a computer-assisted optimization methodology and integrates micellar liquid chromatography (MLC) with other chromatographic and electrophoretic techniques using surfactants.

This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials.

An up-to-date reference that presents the most important information about each area of chemometrics used in chromatography, demonstrating its effective use when applied to a chromatographic separation.

This detailed handbook covers different chromatographic analysis techniques and chromatographic data for compounds found in air, water, and soil, and sludge. The new edition outlines developments relevant to environmental analysis, especially when using chromatographic mass spectrometric techniques. It addresses new issues, new lines of discussion, and new findings, and develops in greater detail the aspects related to chromatographic analysis in the environment. It also includes different analytical methodologies, addresses instrumental aspects, and outlines conclusions and perspectives for the future.

This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to proteins, the text explores the many applications of HILIC in the analytical field. Winner of the President''s Award for Excellence, the author explains how HILIC can significantly improve analytical throughput by shortening sample preparation procedure, which is one of the bottlenecks for drug discovery and development in the pharmaceutical industry.

This book focuses on a relatively new approach to chemical analysis in general, and to separation science in particular. It is the first book to systemically cover the theoretical background, techniques, instrumentation, and practical applications of planar chromatography ¿ mass spectrometry as a hyphenated tool of analytical chemistry. It also examines the high and as-yet unexploited potential of planar chromatography¿mass spectrometry for analytical use in scientific investigations and promotes its expanded use in academia and industry.

This book serves as a comprehensive source of information and training on the state-of-the-art pesticide residues methods performed with aid of HPLC and aids the readers in avoiding the many pitfalls that are possible during work with the HPLC mode

This book provides a comprehensive source of knowledge of new sorbent materials, presenting fundamental principles for their syntheses, and adsorption properties. It presents advanced techniques employed to create specialized sorbents with a wide range of functions, which can be used to enhance the separation and/or purification of useful bioactive compounds, heavy metals, dyes, and more. It discusses original results compared with the most recent developments in the field of separation processes, covering specialized sorbents such as monolith cryogels, composite hydrogels, metal impregnated ion exchangers, and molecularly imprinted polymers.

A great deal of confusion and uncertainty over genotoxic impurity (GTI) identification, assessment, and control exists. This book strives to facilitate scientific and systematic consensus on GTI management by presenting rationales, strategies, practices, and case studies from the pharmaceutical industry. Exploring the safety, quality, and regulatory aspects of GTIs, the text explains the how and why of various GTI control tactics and practices, including GTI control examples in drug substance and drug product development processes from large and small pharmaceutical firms in multiple geographical regions.

An up-to-date, complete reference, this book covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. Part I is devoted to general topics related to TLC in the context of drug analysis. Part II provides an in-depth overview of a wide range of TLC applications for separation and analysis of particular drug groups.

Comprehensively covers the design, construction, and operation of gas chromatography, liquid chromatography, and thin-layer chromatography detectors. This title emphasizes the essential use of common specifications to describe various detectors, allowing easy comparison of their attributes.