Bøger i Contemporary Clinical Neuroscience serien

Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.

A comprehensive collection of the most recent knowledge on the biological bases of various kinds of epilepsies and modern clinical approaches to their treatment.

The proposed book will act as a guide for scientists and clinicians to the unique information that MRS can provide. It will be a comprehensive overview of clinical and pre-clinical MRS applications and potential clinical utility of MRS biomarkers in degenerative brain diseases from leading experts in the field.

An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a "repressor" of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals.

Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia.

Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.

Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia.

This book is a comprehensive overview of the clinical and scientific aspects of Autism from the leading experts in the field. The thorough description of these underlying causes may help researchers and clinicians find more effective treatments and therapies for the 1 in 68 American children who have been diagnosed with Autism.

Comprehensive and authoritative, Neural Mechanisms of Anesthesia draws together and critically reviews all the recent research on anesthetic mechanisms, highlighting the precise routes along which these substances operate, and how this deeper understanding will lead to the design of effective drugs free ofundesirable side effects.

A comprehensive collection of the most recent knowledge on the biological bases of various kinds of epilepsies and modern clinical approaches to their treatment.

Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors.

The Orexin/Hypocretin System provides an overview of all the recent exciting discoveries in the field as well as new findings such as ligand replacement and gene therapies in the animal models of narcolepsy. Several contributions cover sleep and the multiple systems involved in its regulation.

In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond.

This infor- tion is supplemented by chapters on anesthesia and sleep, computational analysis of the state of anesthesia, and the clinical phenomenon of "anesthesia awareness," a topic that has recently received much public attention.

Physicians, nurses, and safety experts comprehensively review sedation and analgesia to provide a completely new reference guide to safe sedation practices consistent with existing guidelines. They also review current mandates for safe sedation practices and address the key clinical issues of pharmacology, monitoring, and recovery.

In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction.

Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging brain influences Alzheimer's disease, ischemia-reperfusion injury, amyotrophic lateral sclerosis, and lifespan [4-6].

Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment.

Molfese, PhD vii CONTENTS Dedication . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 Historical Aspects of Attention Deficit Hyperactivity Disorder . Dykman 2 Scanning the Genome for Attention Deficit Hyperactivity Disorder .

Physicians, nurses, and safety experts comprehensively review sedation and analgesia to provide a completely new reference guide to safe sedation practices consistent with existing guidelines. They also review current mandates for safe sedation practices and address the key clinical issues of pharmacology, monitoring, and recovery.

Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging brain influences Alzheimer's disease, ischemia-reperfusion injury, amyotrophic lateral sclerosis, and lifespan [4-6].

This work presents integrated coverage of recent advances in the molecular mechanisms of neurodegenerative diseases and describes how these mechanisms present new therapeutic targets.

In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction.

Molfese, PhD vii CONTENTS Dedication . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 Historical Aspects of Attention Deficit Hyperactivity Disorder . Dykman 2 Scanning the Genome for Attention Deficit Hyperactivity Disorder .

Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.

In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond.

Presents an account of how genetic abnormalities, neurobiology, and neuropsychology work together to manifest cognitive-behavioral dysfunction. This work reviews the status of research in autosomal disorders that produce cognitive-behavioral dysfunction and syndromal and nonsyndromal disorders that produce mental retardation.