Bøger i Current Histopathology serien

This comprehensive book, lavishly illustrated with over 700 colour pictures, addresses the subject of bone in internal medicine.

Many of the most effective treatments for disease have been discovered empir­ ically. Nowadays, however, we think that understanding the biology of a disease will lead us to design better treatments, and to improve the application of treatments we already have. To accomplish this, vast sums are expended on cancer research. Even so, to the casual observer of clinical oncology the proliferation of studies and trials of ever-different combinations of therapies looks like empiricism, at the best. In the first part of this book, we have asked practising clinicians in different specialities to assess the contributions of biology and of empiricism to current approaches to treatment. In the second part, we have asked researchers in different areas of biology applied to cancer to assess the present and likely future impact of their type of biology on cancer treatment and control. IX 1 Surgery M.BAUM OBJECTIVES OF CANCER TREATMENT The objectives of cancer treatment can be defined according to population requirements or according to the needs of the individual. As far as the population is concerned, Government authorities are entitled to expect that cancer treatment will lead to mortality reductions and cost containment.

Examination of the bone marrow has always been, and to-date techniques whose application will undoubtedly to a large extent still is, within the domain of the haema- increase in the future.

course, also aware that many who use this volume One in every three slides examined by a general diagnostic pathologist in the United Kingdom, and will be well familiar with the classical, or 'textbook', in most other countries, comes from a gynaecological appearances of most of the more common conditions patient.

Needle biopsy of the liver is now an accepted procedure in most large hospitals, and surgeons and laparoscopists are more likely to biopsy the liver under direct vision than in the past.

Examination of the bone marrow has always been, and to-date techniques whose application will undoubtedly to a large extent still is, within the domain of the haema increase in the future.

Early diagnosis of parasitic diseases, especially of the opportunistic infections, is gaining importance daily and pathologists now have the chance to make rapid diagnoses of these disorders by examining tissues and body fluids.

Because of the topographic and pathophysiologic information obtained with contemporary neuroimaging techniques, CT and MR scanning now constitute the most important investigation in clinical neurology.

In the last decade tremendous progress has been made in the diagnosis and treatment of tumours of the mediastinum.

interpretation of histopathological appearances in Detailed accounts of methods of classification lymph nodes. stained with haema Normal structure and function of lymph nodes is toxylin and eosin. Acknowledgements essentially systemic disorders may be reflected in I should like to thank: lymph nodes.

between muscle disorders, muscle biopsy assumed Diseased muscle cells, as any other cell type, show an important diagnostic role. Throughout the atlas I individual morphological features will encourage the have attempted to correlate morphological changes .

Our aim in producing a colour atlas of toxicological guidelines itemize the investigations to be carried out pathology was to present a catalogue of histopathologi during the course of the study and they normally include: cal lesions which we had encountered over the years in clinical observations and behaviour;

Many pathologists have little acquaintance with ear, nose concomitant biopsy have become commonplace in the and throat pathology.

The aim of this atlas is to illustrate the wide range of histological appearances which can be seen in brea. The majority of the photomicrographs are of histological preparations stained with haematoxylin and eosin, buta few special stains have been used to illustrate certain specific features.