Bøger i Current Topics in Microbiology and Immunology serien

Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, while also paving the way for eventually combating thesediseases.

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake.

In addition, the volume discusses the advances made with genetic vaccines, including recent advances with DNA vaccines and the rapid transition of mRNA vaccines from the laboratory to bedside.

This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field.

The role oflncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, pastretroelements integrated within the human genome, as well as the role thesepseudogene-derived lncRNAs play in cancer development are discussed in detail.

The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions.

This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies.

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease.

Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection.

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection..

One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides.

The most feared attribute of the human pathogen Vibrio cholerae is its ability to cause outbreaks that spread like wildfire, completely overwhelming public health systems and causing widespread suffering and death. This volume starts with a description of the contrasting patterns of outbreaks caused by the classical and El Tor biotypes of V. cholerae. Subsequent chapters examine cholera outbreaks in detail, including possible sources of infection and molecular epidemiology on three different continents, the emergence of new clones through the bactericidal selection process of lytic cholera phages, the circulation and transmission of clones of the pathogen during outbreaks and novel approaches to modeling cholera outbreaks. A further contribution deals with the application of the genomic sciences to trace the spread of cholera epidemics and how this information can be used to control cholera outbreaks. The book closes with an analysis of the potential use of killed oralcholera vaccines to stop the spread of cholera outbreaks.

This volume covers all aspects of infection by pathogenic Leptospira species, the causative agents of the world's most widespread zoonosis.

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection..

This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria.

This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells.

This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fc /R), and Fc receptor for IgM only (FcR)];

Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to "molecules and cells that negatively regulate T-cell activation".

This comprehensive, interdisciplinary book covers different aspects of relevant human pathogens and commensals.

From the first detailed clinical description of the disease in the Midwestern United States in 1918, to the isolation of the causative agent, the first of any influenza virus, in 1930 to its role in the genesis of the 2009 human pandemic, swine have played a central role in the ecology of influenza.

Type IV secretion systems (T4SSs) are highly versatile membrane-associated transporter machines used by Gram-negative and Gram-positive bacteria to deliver substrate molecules to a large variety of target cells.

This volume brings together an international group of experts to provide essential insights into spirochete biology, with an emphasis on recent advances made possible by the availability of genome sequences.

In addition, the volume discusses the advances made with genetic vaccines, including recent advances with DNA vaccines and the rapid transition of mRNA vaccines from the laboratory to bedside.

This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus replication inside the cell, and 4) molecular tools for virus study and taxonomy. For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure. Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike.

This volume offers a comprehensive overview of basic and applied aspects of Staphylococcus aureus, which is one of the most important human pathogens. All chapters were written by respected experts in the field - presenting recent findings on a diverse range of aspects, they are nonetheless interlinked.

This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology.

pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations.