Bøger i Handbook of Experimental Pharmacology serien

This book provides an overview on recent progress in anion channels and transporters. It covers multiple scales of analysis ranging from studying the molecular basis of function at atomic resolution to cellular consequences to channel/transporter dysfunction and approaches to correct such processes by pharmacological intervention. Similar anion channels and transporters are expressed in multiple tissues ¿ often fulfilling similar cellular tasks, but also clearly distinct functions. The aim is to combine work on multiple cell and organ systems.

In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.

With contributions by numerous experts

with contributions by numerous experts

with contributions by numerous experts

With contributions by numerous experts

With contributions by numerous experts

This volume is designed to feature the pharmacology of new psychoactive substances, legislative aspects, information exchange including epidemiology, and clinical, forensic, and analytical toxicology in order to facilitate the understanding of this complex and rapidly developing phenomenon.

The main focus of this book is on brown adipose tissue and its metabolic function. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9.

A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments.

This volume gives an overview of new insights to alcohol pharmacology using DREADDs (Designer Receptors and Unraveling the Neuropharmacology of Alcohol). It examines which pharmacological principles should be applied to understanding DREADDs taking into account some very current research.

This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system.

This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

With contributions by numerous experts

with contributions by numerous experts

Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms.

With contributions by numerous experts

With contributions by numerous experts

With contributions by numerous experts

The present volume gives a comprehensive overview on the current state of basic and clinical research on Anxiety and Anxiolytic Drugs. Using newly developed methods and techniques researchers are now beginning to understand the molecular mechanisms of anxiety, anxiety disorders and their treatment.

With contributions by numerous experts

Although many of the individual drugs or classes of drugs administered to animals are the same as, or derived from, those given to man, the safe and effective use of drugs in animals often cannot be achieved by simply transposing knowledge of drug action on, or behaviour in, the body from one species to another.

The inadequacy of current contraceptive technologies is indicated by recent data s- gesting that the contraceptive needs of over 120 million couples go unmet every year.

The purpose of this book is to provide a broad scope of substance use disorder research and how these findings can impact treatment outcomes. The research and outcomes described in this book represent important principles related to identifying and understanding factors related to substance use disorders.

This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders.

In this critical review of the role of neurotrophins and their receptors in pathologies ranging from Huntington's syndrome to clinical depression, contributing authors cover the latest advances in the field, including drugs that manipulate neurotrophin signaling.