Bøger i Immunology and Medicine serien

In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain- ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta- chromasia.

9. Wright, D. J. M. (1980). Reaction following treatment of murine borreliosis and Shwartzman type reaction with borrelial sonicates. Parasite Immunol. , 2, 201-21 10. Tekli. l, B. , Habte-Michal, A. , White, N. J. , Warrell, D. A. and Wright, D. J. M. (1983). Meptazinol diminishes the Jarisch-Herxheimer reaction. Lancet, 1, 835-9 II. Wright, D. J. M. (1973). The significance of the fluorescent treponemal antibody (FTA­ ABS) test in collagen disorders and leprosy. J. Clin. Pathol. , 26, 968-72 12. Noguchi, H. (1911). A cutaneous reaction in syphilis. J. Exp. Med. , 14, 557-68 13. Frei W. (1925). Eine neue hautreaktion bei 'lymphogranuloma inguinale'. Klin. Wochenschr. , 4, 2148-9 14. Murray, J. F. , Felton, C. P. , Garay, S. M. et al. (1984). Pulmonary complications of the acquired immunodeficiency syndrome. Report of a National Heart, Lung and Blood Institute workshop. N. Engl. J. Med. , 310, 1682-8 15. Ehrmann, S. (1907). Versuche uber autoinfektion bei syphilis. Verh. Dtsch. Dermatol. Gesel Berl. , 1,265-70 16. Gluck, A. , cited by Grin E. 1. (1953). Epidemiology and control of endemic syphilis: report on mass treatment campaign in Bosnia. Monograph I I, pp. 34-5. (Geneva: WHO) 17. Neisser, A. , cited by Chesney, A. (1926). Immunity in syphilis. Medicine (BaIt. ), 5,463-87 18. Grimble, A. and Lessof, M. H. (1965). Anti-prostate antibodies in arthritis. Brit. Med. J. , 11, 263-4 xiii 1 Syphilis S. J.

Recent developments in the field of cellular pathology and molecular biology have had a major impact on our ability to diagnose lymphoreticular disease and on our understanding of many of the disease processes which contribute to lymphoreticular pathology.

The various chapters, written by physicians, surgeons, pathologists and immunologists present many of the currently important issues in transplantation and demonstrate that a basic undertaking of immunology is now essential in many areas of clinical practice.

Nineteen eighty-six is a most appropriate year in which to be writing about developments in the organ-specific, autoimmune endocrine diseases. It celebrates the publication 30 years ago in 1956 of the classic papers of Roitt and Doniach and their co-workers I , and of Rose and Witebsky2 and Adams 3 and Purves .

Nineteen eighty-six is a most appropriate year in which to be writing about developments in the organ-specific, autoimmune endocrine diseases. It celebrates the publication 30 years ago in 1956 of the classic papers of Roitt and Doniach and their co-workers I , and of Rose and Witebsky2 and Adams 3 and Purves .

This knowledge has resulted in a better understanding of antibody responses and helped to clarify pathogenic mechanisms in many diseases, particularly autoimmune and allergic diseases, as well as expand our comprehension of antibody deficiency diseases and mechanisms in therapeutic immunization.

Recent developments in the field of cellular pathology and molecular biology have had a major impact on our ability to diagnose lymphoreticular disease and on our understanding of many of the disease processes which contribute to lymphoreticular pathology.

Until recently, the contribution of immunological knowledge to the under standingand management ofENTdisorders was slight, being largely confined to the appreciation that many rhinitic patients were allergic.

The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue.

New vaccines under development include vaccines against hepatitis B, hepatitis A, malaria, vaccines for typhoid, cholera, rota virus infection and other diarrhoeal diseases, leprosy, rabies, the acquired immune deficiency syndrome (AIDS), rubella, EB virus, schistosomiasis and other infections.

A central issue in tumour immunology is whether human tumours express antigens which can be termed tumour-specific. Robins in the introductory chapter in which the expression of antigens in human tumours is compared with that in experimentally induced animal tumours.

The various chapters, written by physicians, surgeons, pathologists and immunologists present many of the currently important issues in transplantation and demonstrate that a basic undertaking of immunology is now essential in many areas of clinical practice.

The eye can become involved in immune-mediated diseases that affect it alone or as part of a multi-organ disease process. Much immunological attention has been focused on other organs affected by these processes and the subject of the immunology of eye diseases is a relatively new one.

Immunotherapy began in 1774 when the Dorset farmer Benjamin Jesty inoculated his wife and two sons with the pus from the teat of a cow suffering from cow pox, using his wife's knitting needle as a vaccinating implement.

In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta chromasia.

The AIDS epidemic has popularized immune deficiency and has led to a rapid increase in the funding for research into the effect of viruses on immunity. AIDS is an important precedent, and it is likely that other less pathogenic retroviruses will eventually turn dut to cause some of the rarer immunodeficiency disorders in children and adults.

After Maureen Young's summary of fetal physiology, Matteo Adinolfi describes the development of the immune system in the fetus, including new information that allows more accurate speculation concerning the gestational age at which fetal immune responses of various kinds may begin.

Diseases of the gastrointestinal tract are common. Specific disease covered include bacterial infections, human immunodeficiency virus (HIV) infection, coeliac disease, and inflammatory bowel disease.

Autoimmunity is the most common cause of endocrine disorders. In addition, it describes developments in our understanding of conditions such as vitiligo and pernicious anaemia which are frequently associated with autoimmune endocrinopathies.

The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed.

Of central importance in autoimmunity is the relationship between antigen pre senting cells (including B cells) expressing MHC class II molecules, autoan tigenic peptides, T helper lymphocytes, and various effector cells.