Bøger i Molecular Biology Intelligence Unit serien

This volume aims to extract and summarize all information about CAK by pointing out commonly accepted facts and unresolved issues. It takes the reader from yeast to mammals and describes all areas that CAK is thought to be involved in. any person interested in cell growth, signal transduction and cancer will find this a useful tool to own.

The book focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Because of a central role of endoplasmic reticulum, calreticulin and calnexin in virtually all cellular functions, the book should be of interest to everyone in the biological sciences.

Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era.

In the concluding chapter of his famous book on the theory of evolution by natural selection, Charles Darwin (1859) remarked that: When the views entertained in this volume on the origin of species, or when analogous views are generally admitted, we can dimly foresee that there will be a considerable revolution in natural history.

The topics covered are sam pling designs (Chapter 2), the estimation of parameters by maximum likelihood (Chapter 3), the analysis of sample counts of the numbers cif individuals in different stages at different times (Chapters 4 and 5), the analysis of data using Leslie matrix types of model (Chapter 6) and key factor analysis (Chapter 7).

This book is about the role of calcium and calmodulin in the cell nucleus. Calcium, which is an important second messenger of signal transduction pathways, can also operate in the cell nucleus. Different calcium binding proteins, which are the targets of cellular calcium, have been identified in the nucleus of many different cell types.

WT1 is a DNA Binding Protein Containing Four C2H2 Zinc Fingers . 113 WTI Mutations in Wilms Tumor . 114 Analysis of WTI Mutations in Tumors Other than Wilms Tumor . 137 Nephrogenic Rests, WTI Mutations and Wilms Tumor . 141 Wilms Tumor and Beckwith-Wiedemann Syndrome . 144 Wilms Tumor and Li-F raumeni Syndrome .

The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice.

This book is about the recent advances in the structural and functional characterization of receptors that influence intracellular signalling events through interaction with intracellular GTP-binding proteins (G proteins).

This book is about the arachidonic acid cascade, its biochemistry, its pharmacology, and its roles in signal transduction.

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. In the first chapter, "The Function of Toll-Like Receptors", Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors.

This book covers vascular endothelial growth factor A (VEGF or VEGFA), a secreted signaling protein. It highlights the central importance of this growth factor for vertebrate development.

This book reviews and summarizes the current state of understanding of the Sonic Hedgehog (shh) pathway and the downstream Gli transcription factors during development. Subsequent chapters deal with the role of Shh during the development of specific organs and body systems in a variety of organisms including zebrafish, mouse and human.

This book covers vascular endothelial growth factor A (VEGF or VEGFA), a secreted signaling protein. It highlights the central importance of this growth factor for vertebrate development.

Excluding the biological polymers proteins, lipids and nucleic acids, modified tetrapyrroles are the biological molecules that have had the greatest impact on the evolution of life over the past 4 billion years.

The Ctbp family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. This book is a comprehensive monograph on the Ctbp family proteins.

This book reviews and summarizes the current state of understanding of the Sonic Hedgehog (shh) pathway and the downstream Gli transcription factors during development. Subsequent chapters deal with the role of Shh during the development of specific organs and body systems in a variety of organisms including zebrafish, mouse and human.

This book provides state-of-the-art insight into Tight Junctions (TJs), the intersection of epithelial and endothelial cells in various tissues.

Integrates knowledge from various disciplines that study muscle function, from single molecule biophysics to flight aerodynamics. This work features information on advances in muscle research, from the molecular to the organismal. It focuses on Drosophila melanogaster, and other species of flying insects are also covered.

Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. In the first chapter, "The Function of Toll-Like Receptors", Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors.

The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland.

This book constitutes the first comprehensive discussion and collection of facts and functions of unconventional secretory pathways, some of which are of importance in human disease and pathology. This comparison of common aspects and similarities in all living cells - from bacteria to man - is an excellent reference book with "textbook" character.

However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.

these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. * *- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules.

Lipid-derived molecules are increasingly appreciated as key regulators of cell responses and signal transduction. Sphingolipid-derived bioactive molecules are emerging as critical regulators of some of the most exciting and, until recently, poorly-understood areas of biology such as growth suppression, programmed cell death and tumor invasion.