Bøger i Molecular Biology Intelligence Unit serien

" -Karl Popper (The Logic of Scientific Discovery) hen I was invited to write this introductory chapter I was hon W ored and pleased to have the opportunity to briefly highlight some important issues relevant to structural aspects of bacterial protein tox ins.

This book is the first one written about the JAK/STAT pathway. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself.

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.

This book summarizes recently gathered information regarding the aminopeptidases. Nomenclature, distributions in the plant and animal kingdoms, structural and compositional information, mechanistic studies, homologies, physiological, medical and industrial uses, and molecular genetics of aminopeptidases are described.

This volume provides an exhaustive review of the most current knowledge of the composition, architecture and dynamics of the nuclear envelope.

The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell.

The Networking of Chaperones by Co-chaperones updates the current understanding of how chaperones are regulated and networked. It is a resource for those in the specialized field of cell stress and chaperones. The book will also be of interest to those in broader cross-cutting field such as cellular networks and systems biology.

Endosomes are a heterogeneous population of endocytic vesicles and tubules that have captivated the interest of biologists for many years, partly due to their important cellular functions and partly due to their intriguing nature and dynamics.

Jointly published with Landes Bioscience, Austin, TX, USA

Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era.

The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine.

Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states.

The purpose of E-Cell System: Basic Concepts and Applications is to provide a comprehensive guide for the E-Cell System version 3 in terms of the software features and its usage.

Compiles the fruits of the studies that have been performed to solve the riddle written in DNA conformation. This book provides a comprehensive overview of the field by covering history of the field, topics, clarifications of research, and future perspective. It serves as a useful source of information on the "conformation code".

Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.

The Annexins is focused on a specific family of calcium and membrane-binding proteins, annexins, ubiquitously spread within living organisms, including animals, plants and fungi.

Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.

The B7-CD28 family molecules are probably the most intensively studied receptor-ligand systems in the field of immunology. This book covers significant territory of this rapidly moving field from structural biology and biochemical signalling to immunological functions and their potential applications in the treatment of human diseases.

This volume provides broad insights to the most recent discoveries in telomere biology, with current applications in tumor diagnostics and future potentials in therapy. This book will be a core reference for any physician, scientist or "educated reader" with an interest in the exciting developments in this research field.

Since its first discovery in the early 90's, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease.

Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling.

Presenting key ideas in the field, this volume explores how transgenics have been used to study p53. The text explores how clinical genetics have identified and mutations in p53 found in human cancers, and how p53 can be regulated by post-translational modification.

Viral Genome Packaging focuses on the process of genome "packaging" within a pre-formed viral procapsid. The chapters of this book concentrate on the biochemistry, enzymology and structural aspects of the genome packaging machinery. The biochemical, biophysical and structural aspects of genome packaging are examined in detail.

Recent advances in genomic sequencing provide the background for analysis of polymorphic sites in large chromosomal regions or even in whole genome, thus providing the tool for effective identification of loci that are under strong pressure of positive selection.

The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland.

This book addresses the most recent advances in the transport of proteins across a variety of biological membranes.

The Networking of Chaperones by Co-chaperones updates the current understanding of how chaperones are regulated and networked. It is a resource for those in the specialized field of cell stress and chaperones. The book will also be of interest to those in broader cross-cutting field such as cellular networks and systems biology.