Bøger i Nucleic Acids and Molecular Biology serien i rækkefølge

Molecular biology is one of the most rapidly developing and at the same time most exciting disciplines. Nucleic Acids and Molecular Biology was created to keep scientists abreast of the explosively growing information and to comply with the great interest in this field.

"e;Editing a book on editing"e; has a certain "e;tongue in cheek"e; connotation to it, and I must admit that I was not aware what the job truly entailed when the project started. However, over the many months that it took to complete the book, it was interesting to realize that indeed "e;printing-type editing"e; and "e;biological editing"e; have many matching characteristics. Therefore, the quote by the well-known ? lm editor Verna Fields (1918-1982), "e;I wish the word "e;editing"e; had never been invented, "e;editing"e; implies correcting, and it's not"e;, can function as a motto for the book: the various biological phenomena that are controlled by the different editing reactions are by far more complex than a simple correction process, and it is astounding how multifaceted the ? eld has become. All chapters of the book focus, as a general "e;editorial"e; subtext, on the corre- tion between RNA structure and function, and on complexity. This involves diff- ent length scales: from complex molecular machineries, to the interplay of complex biochemical pathways, and to evolutionary processes. The chapters are organized in a sequence beginning with a status quo account of RNA editing reactions from the focused perspective of RNA structure. This is followed by a chapter on the structure/function correlation in tRNA editing, and a chapter on RNA editing by adenosine deaminases that act on RNA (ADARs).

This book presents applications of bioinformatics tools that experimental research scientists use in "e;daily practice."e; Its interdisciplinary approach combines computational and experimental methods to solve scientific problems. The book begins with reviews of computational methods for protein sequence-structure-function analysis, followed by methods that use experimental data obtained in the laboratory to improve functional predictions.

Molecular biology has always been a discipline of rapid development. The rapid growth in information leads to ever-increasing specialization, so that it becomes increasingly difficult for a scientist to keep abreast of developments in all the various aspects of the field, although an up-to-date knowledge of the field as a whole is highly desirable.

This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism;

Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology.

The book starts with a personal account of the pioneering work of Stanley Miller and Jeffrey Bada on the Chemistry of Origins of Life and how the development of organic chemistry beginning in the 19th century led to the emergence of the field of prebiotic chemistry, situated at the frontier between organic, geo- and biochemistry.

This book focuses on the regulation of transcription and translation in Archaea and arising insights into the evolution of RNA processing pathways. Topics covered include the modification and maturation of RNAs, the function of small non-coding RNAs and the CRISPR-Cas defense system.

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism;

The book starts with a personal account of the pioneering work of Stanley Miller and Jeffrey Bada on the Chemistry of Origins of Life and how the development of organic chemistry beginning in the 19th century led to the emergence of the field of prebiotic chemistry, situated at the frontier between organic, geo- and biochemistry.

Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology.

This book focuses on the regulation of transcription and translation in Archaea and arising insights into the evolution of RNA processing pathways. Topics covered include the modification and maturation of RNAs, the function of small non-coding RNAs and the CRISPR-Cas defense system.

This volume on nucleic acid nanotechnology offers authoritative, up-to-date and comprehensive coverage of nanotechnological studies and applications of nucleic acids.

This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme.

This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms.

This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme.

This book provides a comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins.

Restriction enzymes are highly specific nucleases which occur ubiquitously among prokaryotic organisms, where they serve to protect bacterial cells against foreign DNA.

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

It is generally accepted that neuropsychiatric disorders have a biological basis. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research.

Human neurological and neuromuscular disorders caused by nucleotide expansion are the focus of growing interest of practicing physicians and of interested biomedical researchers. The authors discuss molecular, clinical and pathological aspects of the diseases as well as our current understanding of their underlying mechanisms.

Human neurological and neuromuscular disorders caused by nucleotide expansion are the focus of growing interest of practicing physicians and of interested biomedical researchers. The authors discuss molecular, clinical and pathological aspects of the diseases as well as our current understanding of their underlying mechanisms.

Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured.

This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses.

Extracellular nucleic acids have recently emerged as important players in the fields of biology and the medical sciences. In addition, extracellular nucleic acids have attracted attention as active modulators of the immune system of higher organisms, including humans.

This book presents applications of bioinformatics tools that experimental research scientists use in "daily practice." The book begins with reviews of computational methods for protein sequence-structure-function analysis, followed by methods that use experimental data obtained in the laboratory to improve functional predictions.

These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another.