Bøger i Nucleic Acids and Molecular Biology serien

Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability.

This volume on nucleic acid nanotechnology offers authoritative, up-to-date and comprehensive coverage of nanotechnological studies and applications of nucleic acids.

The development of agents capable of cleaving RNA and DNA has attracted considerable attention from researchers in the last few years, because of the immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology.

In recent years, unprecedented advances in many aspects of the molecular biology of nucleic acids have been witnessed. At the same time, our structural understanding of DNA-protein interactions has increased enormously, and the related area of RNA-protein interactions is beginning to gather pace.

Restriction enzymes are highly specific nucleases which occur ubiquitously among prokaryotic organisms, where they serve to protect bacterial cells against foreign DNA.

DNA is the central repository of genetic information in the cell, yet it is under constant attack by chemical mutagens, radiation and other processes. But at the heart of all these mechanisms lie proteins that recognize damage to DNA, raising important questions about how damaged DNA may be distinguished.

Other topics include the evolutionary genetics and functional diversification of ribonucleases, engineered ribonucleases as anti-cancer agents, the mechanisms of action of artificial ribonucleases, and ribonucleases as models to understand protein folding and stability.

The field of protein engineering has, however, evolved rapidly since then and the last fifteen years have witnessed remarkable advances through the use of new chemical, biochemical and molecular biological tools towards the synthesis and manipulation of proteins.

With the dramatic increase in RNA 3D structure determination in recent years, we now know that RNA molecules are highly structured.

Extracellular nucleic acids have recently emerged as important players in the fields of biology and the medical sciences. In addition, extracellular nucleic acids have attracted attention as active modulators of the immune system of higher organisms, including humans.

This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms.

In recent years, the discovery of functional small RNAs has brought about an unprecedented revolution within the field of molecular biology. It provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs and the variations encountered in different organisms.

These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another.

It is generally accepted that neuropsychiatric disorders have a biological basis. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research.

The development of agents capable of cleaving RNA and DNA has attracted considerable attention from researchers in the last few years, because of the immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology.

In recent years, the discovery of functional small RNAs has brought about an unprecedented revolution within the field of molecular biology. It provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs and the variations encountered in different organisms.

This book provides a comprehensive description and detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins.

Mechanisms of Transcription presents a unique perspective on the fundamental processes of transcription. Both prokaryotic and eukaryotic systems, NMR and crystallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.

The field of protein engineering has, however, evolved rapidly since then and the last fifteen years have witnessed remarkable advances through the use of new chemical, biochemical and molecular biological tools towards the synthesis and manipulation of proteins.

This volume covers the most important aspects of biosynthesis, processing, and functions of RNA in trypanosomes, ranging from transcription to RNA editing, mRNA splicing/translation/turnover, processing of transfer and ribosomal RNA, RNA interference, and current transcriptome-wide analyses.