Bøger i Progress in Molecular and Subcellular Biology serien

Concerning centromere-specific chromatin modification, it is now evident that all centromeres contain a centromere specific histone H3 variant, CenH3, which replaces histone H3 in centromeric nucleosomes and provides a structural basis that epigenetically defines centromere and differentiates it from the surrounding chromatin.

This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.

Used in ancient oriental medicine as a source of bioactive compounds, sea cucumbers, sea stars and sea urchins are now used for the extraction and purification of cytotoxic, haemolytic, antiviral, antifungal, antifouling, antimicrobial and even anti-tumoural activities.

The articles in the present volume are by major contributors to our under standing of signaling pathways affecting protein synthesis. Since amino acids serve as precursors for proteins, one might expect that with holding an essential amino acid would inhibit the elongation phase.

Lake Baikal is the oldest, deepest and most voluminous lake on Earth, comprising one fifth of the World's unfrozen fresh water. This process is explored using modern molecular biological and cellular biological techniques to outline strategies to fabricate novel materials applicable in biomedicine and nanooptics.

In this book, tumour growth is perceived as a deviation from the normal development of the human organism. Several mechanisms are proposed to explain the distribution of cancers during the human life span and the decline of the incidence of cancers during human senescence.

Cell biologists have recently come to understand that asymmetry of division is an important regulatory phenomenon in the fate of a cell. This book describes the phenomenon in different organisms and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.

Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

In this book, tumour growth is perceived as a deviation from the normal development of the human organism. Several mechanisms are proposed to explain the distribution of cancers during the human life span and the decline of the incidence of cancers during human senescence.

Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action.

Successful aestivation requires the selection of a proper microhabitat, variable degrees of metabolic arrest and responsiveness to external stimuli, the ability to sense the proper time of year for emergence, the preservation of inactive tissue, and much more.

This book is dedicated to understanding how miRNAs affect translation. It includes chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs.

This work focuses on a family of cellular proteins which transmit signals in the form of small molecules outside the cell, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.

Molecules serving as guidance cues for migratory cells, growing axons and for recognition of postsynaptic targets are a major topic for research because they are directly involved in the formation of neuronal circuits, thus creating the foundation for subsequent functional refinement through interactions with the environment.

Concerning centromere-specific chromatin modification, it is now evident that all centromeres contain a centromere specific histone H3 variant, CenH3, which replaces histone H3 in centromeric nucleosomes and provides a structural basis that epigenetically defines centromere and differentiates it from the surrounding chromatin.

This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.

Lake Baikal is the oldest, deepest and most voluminous lake on Earth, comprising one fifth of the World's unfrozen fresh water. This process is explored using modern molecular biological and cellular biological techniques to outline strategies to fabricate novel materials applicable in biomedicine and nanooptics.

This volume explores nuclear structure and trafficking involving or relevant to RNA and RNPs. Topics include advances and current problems in the structural organization of different subnuclear compartments, Cajal bodies and gems, speckles containing splicing factors, and PML bodies characteristic of ProMyelocytic leukemia.

Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while extinguishing the other.

The survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years.

Based on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates.

14 different model systems have been chosen, comprising well known symbioses as well as novel experimental systems which have only recently become amenable to experimental manipulation.

The term cell immortalization refers to the infinite proliferative potential of a cell population. This book describes a selection of the theoretical hypotheses which have been put forward in various attempts to explain this phenomenon.