Bøger i Recent Results in Cancer Research serien

This book, in a new, extensively updated edition, covers viral infection, virus-induced inflammation and tissue injuries, viral epidemiology, oncogenic mechanisms, and current and emerging preventive and therapeutic strategies in detail.

This book presents in detail the problems and ethical challenges in daily oncological practice. Clinical trials with cancer patients and quality assurance for surgery, radiotherapy and medication also pose a series of ethical dilemmas.

Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics.

This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities.

Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics.

With ever increasing demands on the constrained resources available for health care services, no one involved in decision making in health care can continue to ignore the economic costs of the services provided or the relative value for money offered by the available treatments.

Over the years, the management of lymphomatous disease has followed a general trend from the purely empirical and intuitive use of medications to radiation, to surgery, and to chemotherapy with alkylating agents and anti-metabolites. Therefore the pathology is reviewed and these diseases classified before reviewing therapy of the lymphomas.

Used in the proper dose, these carcinogens lead within a few months to the formation of multicentric hepatomas in practically 100 Ufo of the experimental animals, and are therefore a very useful tool for studies of the cytogenesis of cancer (see BUCHNER, 1961;

The growth of the virus in the tumor cells was studied with the electron microscope, in the hope that this might shed some light on the manner in which viral infection transforms a poorly immunogenic tumor into a highly immunogenic one.

From the 1960s onward, the pioneer work of a few investigators clearly showed that hereditary factors were not only related to rare neoplasms, but could also be respon sible for the occurrence of a sizeable fraction of tumors that do not usually show features of inheritance (as in the case of breast or colorectal cancer).

Morbidity and mortality from heart disease and stroke are probably due both to disease and to changes of aging. cancer is clearly a disease and is not a change expected with aging. In the United States about one-half of all cases of cancer are diagnosed after age 65, although those over 65 comprise less than one-eighth of the population.

Is is meant to serve as a guide to individuals planning to form a cooperative group as well as to cooperative groups who wish to revise and refine their existing procedures.

The cloning of hemopoietic cells in semisolid medium began some 12 years ago, and when colonies of T = and B = lymphocytes were grown by several groups last year, the last major subclasses of hemopoietic cells had been successfully cultured in vitro.

Clinical trials with Lipiodol l3ll were started in 1961 by my associate, S. This mono graph describes the extensive clinical evaluation and the radiological results obtained in a large group of patients with malignant lymphomas. the choice of radionuclide, the specific clinical indications and the proper evaluation of the therapeutic effects.

Introduction and Definitions 1 Chapter 2. Biological Basis: Tumour Associated Antigens, the Immune Machinery and Its Behaviour Concerning Cancer Cells 5 2. The Immune Machinery 19 2. Humoral Mediated Immunity and Cell Mediated Immunity 19 2. The Immune Machinery and Cancer Cells 33 2. In vivo Evidence for Tumour Immunity 33 2.

As there is no word for fatigue in the German language, the definition "extreme, unusual tiredness" (in German: extreme, unubliche Mudigkeit), is used to explain the term "fatigue:' This clarification is needed to ensure that future fatigue research conducted in German-speaking countries can be com pared with such research carried out elsewhere.

This book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology.

It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib.

This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies.

This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

This book concisely reviews our current understanding of hypoxia, molecular targeting, DNA repair, cancer stem cells, and tumor pathophysiology, while also discussing novel strategies for putting these findings into practice in daily clinical routine.

It addresses topics such as the effects of obesity on cancer incidence and cancer survival, the effects of weight gain and weight loss in adulthood on cancer risk, the effects of childhood and adolescent obesity, and the role of body fat distribution in cancer risk.

Modern imaging methods have made it possible to detect breast cancer at an earlier stage than in the past. Further chapters are devoted to the pathology of the breast tissue obtained using these procedures, their limitations, the implications of recent advances in breast imaging, and the results of cost-benefit analyses.