Bøger i Research and Perspectives in Endocrine Interactions serien

We are now on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The recognition, for example, that mutant proteins are frequently misrouted molecules, rather than functionally defective ones, changes our approach to "e;inborn errors of metabolism"e; and offers new approaches for pharmacological discovery, based on rescue of receptors, ion channels and enzymes with pharmacoperones. Ion channels, regulators of G-protein signaling and enzymes engaged in regulation, now present opportunities for drug development.The state of our art also benefits by the availability of superior tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.

Avoiding the hyperbole of past treatments of the subject, this book discusses maladies whose diagnoses are much different between males and females. Examples include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia.

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species.

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism.

Recent years have seen spectacular advances in the field of circadian biology. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis.

This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems.

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism.

Overweight is thus being considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders.This volume provides the most up to date insights into the biology of a complex endocrine organ: the adipose tissue.

Not only does size play an important role in the process of cellular proliferation, but body size is also a critical factor in determining which organisms live longer. Evolution has been characterised by a dramatic increase in an organism's body size, which is not only limited to the size of the brain.

This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems.

This volume provides the reader with a pathophysiological perspective on the role of CNS in puberty and adolescence, starting from genetic/molecular aspects, going through structural/imaging changes and leading to physical/behavioral characteristics.

At the beginning of the 20th century, life expectancy at birth in North America and Western Europe was around 50 years of age.

At the beginning of the 20th century, life expectancy at birth in North America and Western Europe was around 50 years of age.

Recent years have seen spectacular advances in the field of circadian biology. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis.

This book covers topics that range from fundamental studies of DNA replication, chromosomal and nuclear function through growth factor control of endocrine tumor initiation and progression.

This volume provides the reader with a pathophysiological perspective on the role of CNS in puberty and adolescence, starting from genetic/molecular aspects, going through structural/imaging changes and leading to physical/behavioral characteristics.

The authors address in particular the role of hormones and their links with other maternal environmental mediators in developmental programming.

Not only does size play an important role in the process of cellular proliferation, but body size is also a critical factor in determining which organisms live longer. Evolution has been characterised by a dramatic increase in an organism's body size, which is not only limited to the size of the brain.

In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "brain-somatic" cross talk is as yet poorly understood, but it is likely to have important implications for the pathophysiology and treatment of obesity, diabetes and other metabolic disorders.

Endocrine disruption is an expanding field due to the numerous chemicals involved and, as evidenced more recently, the variety of homeostatic systems that they can alter throughout life. The research needs have been discussed as well as recommendations prioritizing target groups and following the precautionary principle.

Endocrine disruption is an expanding field due to the numerous chemicals involved and, as evidenced more recently, the variety of homeostatic systems that they can alter throughout life. The research needs have been discussed as well as recommendations prioritizing target groups and following the precautionary principle.

Avoiding the hyperbole of past treatments of the subject, this book discusses maladies whose diagnoses are much different between males and females. Examples include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia.

Overweight is thus being considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders.This volume provides the most up to date insights into the biology of a complex endocrine organ: the adipose tissue.

In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "brain-somatic" cross talk is as yet poorly understood, but it is likely to have important implications for the pathophysiology and treatment of obesity, diabetes and other metabolic disorders.

Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species.

This book concentrates on two major topics: firstly, the molecular and neural biology of hormone actions relevant to normal social behaviors; and secondly, the clinical treatment of human patients in whom these behaviors have gone wrong.