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This book provides the first comprehensive and systematic overview of biology, mechanism, and structure of RNA helicases and RNA helicase-like enzymes.
This book examines the many aspects of the drug discovery process and presents the current state-of-the-art and a clear overview of approaches to lead identification.
Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability.
The book provides up-to-date reference source for researchers. Introductory sections to each topic are followed by detailed discussions for the experienced biochemist.
A collection of methods to determine and analyse the 3-D structure of biomolecules. These methods have been enhanced to improve the speed and quality of drug discovery.
This book provides a representative snapshot of the very latest key developments in this multidisciplinary subject.
Written by leaders in the field, this volume describes the preparation and application of DNA-conjugates. Several have been used as sensors whilst others link reporter groups such as proteins or fluorophores to RNA or DNA for detection, single molecule studies, and increasing the sensitivity of PCR.
This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts.
This two volume set describes innovations in biomolecular modeling and simulation, in both the algorithmic and application fronts.
Edited by leading biological NMR spectroscopists, this book covers the new developments that have occurred in biomolecular NMR over the last few years.
This exceptional monograph, by experts in structural biology and virology, is for biomedical scientists involved in basic and applied research.
With contributions from experts in the field, this book provides a comprehensive overview of the oxidative folding of cysteine-rich peptides.
This book, written by expert scientists in the field, analyses how diverse fields of scientific research interact on a specific example - RNA polymerases.
This accessible introduction to modern theories of enzyme catalysis presents the latest methods for studying quantum tunnelling in biological systems.
This book highlights recent advances in the way computer simulation can be applied to the field of membranes and membrane proteins.
In this comprehensive resource the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology.
Written by a team of experts, this book bridges the gap between the DNA- and RNA- views of protein-nucleic acid recognition which are often treated as separate fields.
Written by leading experts, this book provides a comprehensive overview of protein-carbohydrate interactions for researchers.
This book provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand binding mechanisms. Suitable for biomolecular scientists at graduate or post-doctoral level in academia and industry. Biologists and chemists will also find it a useful introduction to the techniques available.
This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.
Provides a perspective on nucleic acid-metal ion interactions with an emphasis on experimental biophysical studies which will prove indispensable to biophysicists and molecular biologists.
This book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important or promising for cancer treatment.
The emphasis of this book concerns the origins of catalysis in RNA and is well suited for undergraduates, postgraduates and researchers in catalytic chemistry.
This unique book covers all the modern approaches and the many advances experienced in the field of protein folding and aggregation during the last 10 years.
This book provides a compelling overall update on current status of RNA interference
This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the physiological factors of pharmacology, a key area, is explored.
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