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Integrating social, cultural, economic, and political history, this is a study of the factors that grounded - or swayed - the loyalties of non-Spaniards living under Spanish rule on the southern frontier. In particular, Andrew McMichael looks at the colonial Spanish administration's attitude toward resident Americans.
The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens.
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