Bøger af David Finkelstein

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

The Scottish publishing house of William Blackwoood & Sons, founded in 1804, was a major force in 19th- and early 20th-century British literary history, publishing a diverse group of important authors, including George Eliot and Joseph Conrad. This is a look at its success and eventual demise.

The declaration of the Peoples Republic of China in October 1949 presented American foreign policy officials with two dilemmas: how to deal with the communist government on the mainland and what to do about Chiang Kai-sheks holdout Nationalist regime on Taiwan. By early 1950 these questions were pressing hard upon U.S. civilian and military planners and policy makers, for it appeared that the Red Army was preparing to invade the island. Most observers believed that nothing short of American military intervention would preclude a communist victory on Taiwan. How U.S. officials grappled with the question of what to do about Taiwan is at the heart of this study.Prior to the publication of this book, much of the historical literature on this critical period in U.S. policy toward China concentrated on the question of relations with the new regime in Beijing. A focus on those debates has largely overshadowed the concomitant policy debates that centered around the question of how to deal with the Nationalist regime on Taiwan. As this study shows, the two issues were inextricably linked and developing a Taiwan policy was no less difficult or controversial. Heavily informed by an analysis of declassified U.S. government documents and other primary sources, this history strongly suggests that had North Korea not invaded the south in June 1950 the U.S. would not have intervened to save Chiang Kai-shek and Taiwan from near-certain invasion.Beyond the narrative itself, this volume is also a case study into the complex and sometimes messy processes by which foreign policy is made. It explores the tensions that existed within the Truman administration between the State Department and various newly-created entities such as the Department of Defense, the Joint Chiefs of Staff, and the National Security Council. Indeed, the history of policymaking for China and Taiwan in 1949-50 is also a case study in the early development of the post-war interagency system. It also underscores the tensions between the Executive and Legislative branches in the development of foreign policy.The study also brings to light little-discussed and often uncomfortable issues in Taiwan history, some of which still have relevance to politics on the island even today. These include the legacies of the Japanese colonial experience, the post-war Nationalist occupation, and the early stirrings of the Formosan independence movement, to name just a couple.Today, U.S. policy toward Taiwan remains a highly-charged and fundamentally divisive issue in U.S.-China relations especially the security dimensions of that policy. And even today U.S. Taiwan policy is still subject to partisan politics in Washington as well as in Taipei. For those who still grapple with this issue, this volume presents the roots of the dilemma and essential background reading.