Bøger af Deborah Wallace

Claire Dickens fled...Accused by the sheriff of murdering her ex-husband, the deputy, she hides from the real killer.Enraged over his best friend's death, Brad Hayes tracks Claire down. Once she convinces him of her innocence, they labor together to expose the killer's secrets.Working in close quarters, with the threat of death at every turn, their long buried love resurfaces, giving Brad more reason to save Claire. They may have to face a choice...will one need to die to protect the other?

Protein folding dysfunctions like Alzheimer's and Parkinson's Diseases present intractable medical challenges: drug treatments are, at best, palliative, failing to alter ultimate disease course. Effective intervention will require a deeper understanding of protein folding and its regulation, particularly in view of a sixfold rise in the inflation-adjusted cost of bringing drugs to market since 1950. As a consequence, the pharmaceutical industry has sharply curtailed research on a range of poorly-understood afflictions, including Alzheimer's Disease. That is, in all likelihood, there will not be effective drugs for many protein folding disorders anytime soon, and, if produced, the costs will be prohibitive. Here we follow protein folding and its failure from the cellular to social levels of organization, finding a strong foundation for effective public health interventions against the early onset of disease.

As a follow-up to COVID-19 in New York City: an Ecology of Race and Class Oppression, which showed that decades of discriminatory public policies shaped the Bronx into the epicenter of the first wave of COVID-19, this book examines the build up to the crest and subsequent ebbing of the second wave of COVID-19 across the 62 counties of New York State (NYS) and 152 ZIP Code areas of the four central boroughs of New York City (NYC). Like its predecessor, the sequel examines the vulnerabilities that give rise to spikes in infection rates that form epicenters. Unlike the first wave, NYC was not the epicenter of the second wave; high-incident counties just outside NYS formed an extended initial epicenter and exported COVID-19 to neighboring counties of NYS. Rural NYS counties differed significantly from urban ones socioeconomically and in infection rates during the cresting period. Before the crest, no socioeconomic factor was associated with county infection rates; rather, the major associating factor was political and cultural: percent of the 2020 vote garnered by Trump. Rural counties voted heavily for Trump. This association disappeared post-crest by mid-January 2021. In NYC, the Bronx again behaved like a single high-incidence entity, unlike the other three boroughs that had patches of high and low infection incidence. Among the topics covered:The Second COVID Wave Washes Over New York StateThe Second Wave Storm-Surges Across New York CityDiscussion of County Data from the Second Wave of COVID-19Parsing Meaning From the 152 ZIP Code Data The book closes with a prescription for pandemic response planning based on empowered communities and workers interacting with health departments as equals. The Recurrence of COVID-19 in New York State and New York City is a valuableresource for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also will find readership among students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.

This book is the first social epidemiological study of COVID-19 spread in New York City (NYC), the primary epicenter of the United States. New York City spread COVID-19 throughout the United States. The context of epicenter formation determined the rapid, extreme rise of NYC case and mortality rates. Decades of public policies destructive of poor neighborhoods of color heavily determined the spread within the City. Premature mortality rates revealed the "weathering" of policy-targeted communities: accelerated aging due to chronic stress. COVID attacks the elderly more severely than those under the age of 60. Communities with high proportions of prematurely aged residents proved fertile ground for COVID illness and mortality. The very public policies that created swaths of white wealth across much of Manhattan and parts of Brooklyn destroyed the human diversity needed to ride out crises. Topics covered within the chapters include: Premature Death Rate Geography in New York City: Implications for COVID-19 NYC COVID Markers at the ZIP Code Level Prospero''s New Castles: COVID Infection and Premature Mortality in the NY Metro Region Pandemic Firefighting vs. Pandemic Fire Prevention Conclusion: Scales of Time in DisastersAn exemplary study in health disparities, COVID-19 in New York City: An Ecology of Race and Class Oppression is essential reading for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also should appeal to students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.

An indictment of the decision to close fire companies in New York City in the 1970s, and a frightening study of the way misguided and malevolent social policy can spark a chain reaction of enormous and unforeseen urban collapse.

This volume examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner.

RTW states on average and median have lower life expectancy, higher obesity prevalence, and higher rates of all-cause mortality, early mortality from chronic conditions, child mortality, and risk behaviors than non-RTW states.

This volume examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner.

This book introduces a cutting-edge mathematical formalism based on the asymptotic limit theorems of information theory to describe how punctuated shifts in mesoscale ecosystems can entrain patterns of gene expression and organismal evolution.