Bøger af Melonie Armstrong

Osteoimmunology is the study of the correlation between bone and immune cells. It emphasizes the two sided communication that takes place among the immune cells and bones. The interactions taking place between the immune system and bone are critical in maintaining skeletal homeostasis. The bone marrow cavity is essential for the growth of the immune system. It also houses crucial stem cells for maintaining the immune system. Immune cells create cytokines, which have crucial effects on the modulation of bone homeostasis. There are a few critical cytokines, which are produced by the immune system, such as TNF-α, RANKL, IFNs, M-CSF and ILs. These affect the activity and differentiation of bone resorption and osteoclasts. This book is a valuable compilation of topics, ranging from the basic to the most complex advancements in the field of osteoimmunology. It will prove to be immensely beneficial to students and researchers in this field.

Osteoimmunology refers to a field of study that investigates the interface between the skeletal system and the immune system, also known as the osteoimmune system. It also investigates the components and mechanisms of these two systems in vertebrates, such as signaling molecules, ligands, transcription factors and receptors. This field is studied clinically for treating various diseases like rheumatoid arthritis (RA), periodontitis, osteoporosis, bone metastases and osteopetrosis. The study of the interactions between the immune system and skeletal system reveal relations that exist between structural pathologies and molecular communication taking place in the blood cells. Clinical osteoimmunology is a domain which focuses on the prevention and treatment of diseases related to the bone, which are caused by immune system disorders. Bone destruction and osteoporosis are diseases caused by the disorders of the osteoimmune system. These diseases are accompanied by RA, characterized by high infiltration of CD4+ T cells in the rheumatoid joints. This book explores all the important aspects of osteoimmunology in the present day scenario. The topics covered herein offer the readers new insights on the interactions between the immune system and the skeletal systems.

Osteoimmunology refers to an interdisciplinary research field that combines the field of immunology and osteology. It focuses on the potential treatments and mechanisms associated with bone related diseases, such as rheumatoid arthritis, periodontitis and osteoporosis that are caused by or linked with failure of the immune system. Receptor activator of nuclear factor kappaB ligand (RANKL) is the prime regulator of osteoclastogenesis. It is known to be responsible for the increased activation of osteoclasts, such as direct activation of T cells and indirect increase in the expression of RANKL, and consequently promoting osteoclastic activity. Osteoblasts have significance in the maintenance of the hematopoietic stem cell. Furthermore, they are also relevant in the development of lymphocytes, along with immune cell functions in the development of osteoclast and osteoblast. This book elucidates the concepts and innovative models around prospective developments with respect to osteoimmunology. Also included herein is a detailed explanation of the molecular mechanisms and clinical applications of this field. Those with an interest in this field would find this book helpful.