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Hindu cosmology had the concept of Yugas and cyclical creation and destruction of the universe. The initial yuga was Satya Yuga which lasted 1,72,800 years. This was the best of the yugas with truth, perfection and one-world religion. The individuals in this yuga were saintly, gigantic, powerfully built, honest, youthful and valorous. The second yuga was the Treta yuga which lasted 12,96,000 years. The virtue became less in Treta yuga. The Emperors became dominant resulting in frequent wars. The oceans and deserts were formed during this period. The third yuga is the Dvapara Yuga which lasted for 8,64,800. The individuals of the Dvapara yuga were tainted and had tamasic qualities. Diseases occurred during this period. The individuals lived for a few centuries less in this yuga. The present yuga is Kali Yuga which started in 3200 BC. There was darkness, lack of virtue, sin and hypocritism in the individuals during this yuga. Global warming due to human activity leads to archaeal overgrowth. The archaeal growth in the ocean beds and release of methane leads to earthquakes and tsunamis leading to catastrophic end of each yuga.
Modern civilization results in stress in societies leading to increased activation of the HPA axis leading to increased secretion of stress hormones the catecholamines producing increase in sympathetic tone. The increase in sympathetic tone leads to increase in stress hormones epinephrine and norepinephrine producing breeching of the gut blood barrier. This leads to decrease in mucin secretion lining the gut wall and inflammatory changes in the colonic mucosa. Modern civilization results in changes in dietary habits leading to less consumption of fibre and more intake of protein and fat. This leads to increased colonic archaeal growth and archaeal endosymbiosis. The endosymbiotic archaeal growth leads to a new neanderthalic phenotype as a stress adaptation syndrome. The archaeal endosymbiosis leads to the induction of a new metabolic phenotype with mitochondrial dysfunction and anaerobic glycolysis- the Warburg phenotype. The Warburg phenotype produces immune activation consequent to increased lymphocytic glycolysis producing autoimmune disease.
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