Bøger af Sam Lehmann

Drug discovery is the process of identifying novel therapeutic entities, with the combination of clinical, computational, translational and experimental models. This is done through the inventive process of drug design, which discovers novel medications on the basis of information about a biological target. Drug design process involves designing of molecules, which are complementary in charge and shape of the molecular target with which they will bind and interact. This process of designing drugs utilizes bioinformatics approaches and techniques of computer modeling but is not totally dependent on them. In spite of various advances in the field of biotechnology and in the understanding of biological systems, the process of drug discovery is difficult, costly and lengthy. There is a high rate of attrition in the discovery of new therapeutics. This book contains some path-breaking studies on drug discovery and design. Also included herein is a detailed explanation of the methods, challenges and applications of drug discovery and design. A number of latest researches have been included to keep the readers up-to-date with the global concepts in this area of study.

Drug discovery refers to the process of finding potential new therapeutic entities by using a combination of translational, computational, experimental and clinical models. The process of developing new drugs based on an understanding of a biological target is known as drug design. It entails designing molecules with shapes and charge which is complementary to the molecular target with which they bind and interact. Preclinical research using animal and cell-based models, clinical trials on humans, and obtaining regulatory approval to market the drugs are the key steps involved in the development and discovery of new drugs. Modern drug discovery encompasses the identification of screening hits, medicinal chemistry and optimization of those screening hits to improve their selectivity, metabolic stability, affinity, oral bioavailability and efficacy. This book explores all the new frontiers in drug design and discovery. It covers in detail some existent theories and innovative concepts revolving around this domain. The extensive content of this book provides the readers with a thorough understanding of the subject.