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Kurkjian and Zelen (1963) gave the analysis of block designs using the calculus and Zelen and Federer (1964) applied it to the analysis of designs with two-way elimination of heterogeneity.
Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors.
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