Bøger udgivet af Cold Spring Harbor Laboratory Press,U.S.

"There are thousands of diseases classed as "rare" because they afflict only a small number of people. These patient groups were long ignored by a pharmaceutical industry that judged them too small to provide a return on the investment needed to develop an effective remedy. Forty years ago, a revolution started that transformed the prospects of patients with rare diseases. This book is in part a history, with eyewitness accounts of advances as they occurred and portraits of the pioneering scientists and physicians, tireless activists, and visionary business leaders who made the revolution happen, and it tells deeply personal stories of patients and parents willing to risk new, untried therapies"--

Written and edited by experts in the field, this collection reviews our understanding of breast cancer epidemiology, the molecular and cellular mechanisms underlying its progression, and recent advances in tumor prevention, detection and treatment. The contributors discuss how work using animal models, patient-derived xenografts, and organoid cultures, together with new imaging approaches, is providing new insights into the molecular pathology of breast cancer.

The MRC Laboratory of Molecular Biology (LMB) in Cambridge, UK is a world-leading scientific institution. This book, by LMB alumna Kathy Weston, is a collective portrait of women scientists who, as staff members, visitors, and trainees, helped build the LMB's reputation as a powerhouse of science, often going on to stellar careers at other outstanding institutions around the world. Combining narrative history with interview transcripts and personal reminiscence, Weston's book describes the career accomplishments of these successful scientists in the context of their lives as a whole, and how they manage goals and priorities, particularly around personal and family lives. The book provides future sisters in science with role models and inspiration but is recommended reading for everyone intent on combining success in research with a satisfying life outside science.

This book reviews our current understanding of the cellular, molecular, and biophysical mechanisms involved in skin wound healing, as well as the function and regulation of different skin cell types, including epithelial cells, fibroblasts, immune cells, neural cells, and endothelial cells.

Essentials of Glycobiology is the field's most authoritative textbook, offering an overview suitable for advanced undergraduates and graduate students in molecular and cellular biology and biomedicine. In an entirely revised and updated fourth edition, the book retains a broad focus and applicability to fields ranging from biology and medicine to chemistry and materials science, with excellent artwork and chapters written by an international selection of leading investigators.

Written and edited by experts in the field, this collection from explores the biological basis of regeneration in diverse animal species and how this knowledge can be applied therapeutically in humans. The contributors discuss the dramatic molecular and cellular changes that occur when a regeneration program is initiated, the progenitor cells and morphogenic signals involved, the formation of a blastema, the roles of reprogramming and polyploidy, the diversity of cell fates, the integration of new structures with existing body parts, and our current understanding of why some structures are more resistant to regeneration than others.

Written and edited by experts in the field, this collection summarizes recent progress in this area. It includes contributions covering epigenetic mechanisms in the brain, neuroendocrine responses to stress, and the evolution of reversed sex differences in the behavior of spotted hyenas, as well as studies of how sex differences may affect circadian rhythms, immune disorders, and depression.

Written and edited by experts in the field, this collection covers recent advances in our understanding of nuclear organization and function. The contributors discuss the 3D organization of chromatin, the various nuclear bodies and compartments that have been identified, and the roles of RNA and actin in shaping nuclear organization, as well as how these structures interact with each other and with peripheral features (e.g., the nuclear pore complex and inner nuclear membrane proteins) to carry out the work of the nucleus. Insights into DNA replication timing and RNA processing dynamics based on new technologies aimed at examining chromatin and other intranuclear structures at high resolution are also included.

Written and edited by experts in the field, this collection covers recent insights into how auxin levels are regulated and, in turn, drive various developmental processes in plants. The contributors discuss the biosynthesis, conjugation, and degradation of auxin, the various transporters, receptors, and transcription factors involved in auxin signaling, the interactions of auxin with other plant hormones, and how these are spatiotemporally coordinated. The roles of auxin in specific organs and tissuesDLthe shoot apical meristem, roots, vasculature, and flowersDLare described in detail. The evolutionary history of auxin signaling and its roles in environmental responses (e.g., plantâ€"pathogen interactions) are also reviewed.

Written and edited by experts in the field, this collection examines advances in causal inference approaches in human genetics and how they are being used to enhance our understanding of human development and disease. The contributors discuss family-based study designs for causal inference, including twin designs, adoption designs, and in vitro fertilization designs, that separate inherited factors from perinatal environmental exposures. They also review various types of Mendelian randomizationDLa population-based approach that is growing in utility and popularityDLas well as their integration with family-based designs.

Written and edited by experts in the field, this collection covers the progress that has been made in understanding the molecular pathogenesis of lung cancer and how this information is leading to improved detection and treatment strategies. The contributors review the genomic, transcriptomic, epigenomic, and proteomic changes associated with lung carcinogenesis, the histologic and metabolic features of different types of lung cancer, and the roles of the immune microenvironment and cancer stem cells in tumor maintenance and metastasis. The large databases of demographic and clinical information, high-throughput platforms that generate molecular data, advanced computational methods, and preclinical models that facilitate advances in basic and translational research are also covered.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the arsenal of memory T-cell subtypes in the body and how they function as key components of the adaptive immune system. The contributors examine the heterogeneity and diversity of memory T-cell subtypes, how they are classified and named, and their biological characteristics--their transcriptional and metabolic features, migration patterns, life spans, and surveillance activities. The differentiation of T cells from a naive state, how they establish and maintain a primed memory state, and factors that contribute to their decline are all covered.