Bøger udgivet af Elsevier Science Publishing Co Inc

Recent advances in pharmacology and brain stimulation have led to the development of novel treatments for psychiatric disorders. These new advances have led to the development of a new subspecialty, Interventional Psychiatry. Interventional Psychiatry: Road to Novel Therapeutics reviews all specialized treatments including device-based interventions such as electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS). This book discusses the procedure-based pharmacologic interventions including ketamine infusion therapy and psychedelic therapies. Internationally contributed, this book outlines the state of the field, as well as implications for training and the role of the interventional psychiatrist in treatment teams.

Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics, Volume Two examines implications on public health and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments. The book cover topics on pharmacokinetics and toxicokinetics, such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. In addition, it investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. Final sections discuss the mechanistic pathways of food toxicants and illustrate the molecular mechanisms of the chemopreventive role of dietary phytochemicals. Ethical, legal, societal, and professional issues in toxicology round off coverage, making this a valuable resource for anyone interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments.

Retinal and Choroidal Vascular Diseases of the Eye explores a variety of retinal and choroidal vascular diseases, covering their pathogenesis, clinical features, and management strategies. The book begins with an outline of the basic features of retinal and choroidal vasculature before moving on to imaging techniques. Chapters then delve into specific diseases and abnormalities, as well as vascular diseases that are associated with systemic inflammatory diseases. The book then moves onto considering vascular diseases associated with system conditions before considering vascular tumors. Recent innovations and upcoming treatment options are also explored for the various diseases throughout the book. This comprehensive reference provides a deep dive into vascular diseases of the eye, and is a must-have reference for ophthalmologists, medical and surgical retina specialists, and researchers in related fields.

Nanotoxicology for Agricultural and Environmental Applications provides an introduction to nanotechnology and its applications in agriculture and the environment. This reference, especially focused on the role of each physicochemical property of nanomaterials in toxicity, also presents a consolidated discussion on the management of the risks associated with nanoparticle use and rules and regulations made by various countries and organizations around the world.Structured into five parts, this book explores nanotoxicity concerning agriculture and food, its impact on the environment, risk management measures for avoiding exposure, and delves into the realm of nanotechnology regulations. Students, practitioners, and researchers working in plant science, agricultural science, nanoscience, and environmental chemistry alike will benefit from this necessary reference.

Parameter Estimation and Adaptive Control for Nonlinear Servo Systems presents the latest advances in observer-based control design, focusing on adaptive control for nonlinear systems such as adaptive neural network control, adaptive parameter estimation, and system identification. This book offers an array of new, real-world applications in the field. Written by eminent scientists in the field of control theory, this book covers the latest advances in observer-based control design and provides fundamentals, algorithms, and key applications in the fields of power systems, robotics and mechatronics, flight, and automotive systems.

Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds will be of great interest to undergraduate and graduate students, scientists, researchers, and engineers who work on the microbial production of plant-derived bioactive compounds. As many plant-derived bioactive compounds are the foundation of effective drugs to cure diseases, it's important to understand the limits of their applications in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast. This book summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing the content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks.

Exosomal RNA: Role in Human Diseases and Therapy provides an in-depth study of exosomes and their RNA in the context of a variety of diseases. The book explores the diagnostic and therapeutic potential of exosomal RNA as biomarkers across a range of different conditions, including cancer, type 2 diabetes, cardiovascular and renal disease, as well as bacterial infections and tissue repair. The link between exosomal RNA expression and neurodegenerative disease is also explored. The book goes on to share the significance of exosomal RNA in preserving cellular function, with special attention given to their role in the autophagy process. This book also gives an overview of the isolation, characterization, and potential applications of exosomal RNA, providing researchers with an understanding of how they can be manipulated and utilized for the treatment of various diseases and conditions. This is an ideal reference for researchers in the field of molecular biology, cell biology, and related fields, as well as those involved in the development of therapeutics and personalized medicine.

T Cell Metabolism and Cancer Immunotherapy delves into the intricate regulation of T-cell immunity and tolerance. As research advances in cell-based therapies, the potential of engineered immune cells to treat cancers and other diseases is becoming increasingly evident due to their powerful capabilities. Additionally, the book offers valuable insights into developing and optimizing strategies for bacterium-based immunotherapies. Despite great advancement in immunotherapy such as adoptive T cell transfer-based regimen, the clinical outcomes remain less satisfactory due to a variety of factors that lessen its therapeutic efficacy. By determining the role and importance of T cell metabolism in the regulation of T lymphocytes that are related to the development and managements of aberrant immunity, T Cell Metabolism and Cancer Immunotherapy designs and develops novel and more effective strategies for improving regimens for patients with aberrant immunity. Within ten chapters the content not only reveals targets of T cell metabolism as critical determinants of immune regulation, but also uncovers unique therapeutic opportunities to improve immunotherapy through targeting T cell metabolism. This fills a significant gap in the knowledge of scientists working in the field of onco-immunology/immunotherapy, and students learning about T cells, metabolism, immunomodulation, and immunotherapy.

Artificial Intelligence for Medicine: An Applied Reference for Methods and Applications introduces readers to the methodology and AI/ML algorithms as well as cutting-edge applications to medicine, such as cancer, precision medicine, critical care, personalized medicine, telemedicine, drug discovery, molecular characterization, and patient mental health. Research in medicine and tailored clinical treatment are being quickly transformed by artificial intelligence (AI) and machine learning (ML). The content in this book is tailored to the reader's needs in terms of both type and fundamentals. It covers the current ethical issues and potential developments in this field. This book will be beneficial for academics, professionals in the IT industry, educators, students, and anyone else involved in the use and development of AI in the medical field.

Pediatric and Adult Coeliac Disease: A Clinically Oriented Perspective provides an up-to-date, comprehensive, and critical overview of coeliac disease, its complications, and related disorders. The book covers epidemiological, pathogenetic, diagnostic, and treatment issues, including pediatric and adult cases, with a broad and international view. This is the perfect reference for researchers dedicated to advancing the field of translational coeliac disease research as well as clinicians who are diagnosing and managing coeliac disease throughout all of its various stages.

Metaheuristics Algorithms for Medical Applications: Methods and Applications provides readers with the most complete reference for developing metaheuristics techniques with machine learning for solving biomedical problems. This book is organized to present a stepwise progression beginning with the basics of metaheuristics, leading into methods and practices, and concluding with advanced topics. The first section of this book presents the fundamental concepts of metaheuristics and machine learning and provides a comprehensive taxonomic view of metaheuristics methods according to a variety of criteria such as data type, scope, and method. The second section of this book explains how to apply metaheuristics techniques for solving large-scale biomedical problems, including analysis and validation under different strategies. The final portion of the book focuses on advanced topics in metaheuristics in four different applications. Readers will discover a variety of new methods, approaches, and techniques, as well as a wide range of applications demonstrating key concepts in metaheuristics for biomedical science. This book provides a leading-edge resource for researchers in a variety of scientific fields who are interested in metaheuristics, including mathematics, biomedical engineering, computer science, biological sciences, and clinicians in medical practice.

Beneficial Microbes for Sustainable Agriculture under Abiotic Stress: Functional Traits and Regulation highlights the potential for microbe-mediated stress phytotolerance to be improved by presenting multiple scenarios of application and results. In most research and studies, abiotic stress is applied singularly to specific plants inoculated with a bioinoculum or a microbial consortium to isolate specific plant-microbe responses. However, in reality, plants are continually exposed to a multitude of different stresses simultaneously occurring. This book presents microbial functional traits and microbe-mediated plant responses under both specific or combined stress conditions. Collectively, it provides insights into microbial functional traits and microbe-mediated plant responses in a wide range of conditions, providing foundational understanding of their potential benefits, and inspiring further research. The book also centers on specific microbial strains and groups which have been shown to effectively promote stress tolerance, and which could be utilized to boost agricultural production under stress conditions. Their potential utilization in stress affected lands not just improves crop production but could also be in line with sustainable agriculture. With the advancement of tools such as omics related technologies, emerging information on microbial functional traits and regulations on microbe-mediated phytotolerance will also allow us to develop relevant biotechnologies harnessing potentials of plant-microbe interactions under stress conditions. The information in this volume will be of interest to those working toward these next steps.

Biochemical Immunology of Diabetes and Associated Complications offers in-depth coverage of the association of biochemical and immunological aspects of the human body in diabetes. It discusses the suppression and modulation of the immune system and the impact of immunochemicals on the biochemical pathways in diabetes, along with associated complications. The book enumerates the exigency in knowledge about the immunomodulators as therapeutic targets to cure the syndrome. It will serve as an important reference for medical practitioners, researchers, medical students, masters and doctoral students. In addition, it could also be used as a reference for science graduates, science teachers, and researchers.

Paraneoplastic Neurological Disorders, Volume 200 covers new, recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. Besides investigating the pathogenetic mechanisms of these disorders, this book also explores what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy are teaching us in terms of immunopathogenesis. Following sections present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ, and muscle. Finally, the book investigates the role of antibody markers that differentiate by cytoplasmic, nuclear, and neuronal cell surface reactivities. Side effects of the new immuno-oncological drugs increasingly used in cancer therapy are also covered.

Mite-Human Interactions: Nuisances, Vectors, Parasites, Allergens, and Commensals offers coverage on the neglected topic of mites, their diversity, and the conditions caused or vectored by them. The first part of the book differentiates the types of mites as arthropod-borne infectious disease vectors (scrub typhus, rickettsialpox), as bothersome pests (animal and itch mites), as potential allergens (dust and food mites), and as human commensals (follicle mites). The book further provides information on how to diagnose and treat mite-borne infections, infestations, and allergies and recommends ways to prevent and control them. In addition, the book also delves into topics such as the potential psychological impact of mites with the unusual condition of delusional parasitosis, also known as known as Morgellons disease and addresses the socioeconomic disparity issues in infections, infestations, and mite-associated conditions.

?Artificial intelligence, Big data, Blockchain and 5G for Digital Transformation of Healthcare Industry: A Movement Towards More Resilient and Inclusive Societies delivers a collection of relevant innovative research on digital healthcare, with a three mains goals: 1) study the successes and failures in the field of IT and digital health during the pandemic, and analyze the lessons from these cases; 2) discuss the latest advances in the field of digital healthcare, with a special focus on Artificial Intelligence, Big Data, Blockchain and 5G; and 3) discuss implications for main stakeholders (patients, doctors, IT experts, directors, policy managers. The global outbreak caused by covid-19 caused global disruption in societies, healthcare systems, and economies around the world. This book provides insight to Researchers, clinicians, CEOs and policymakers who need to learn from the failures and successes and exploit the potential of advanced information technologies to build stronger healthcare systems, better quality healthcare services, and more resilient societies.

Development of Gluten-Free Pasta summarizes current progress in the development of gluten-free (GF) products, focusing particularly on pasta products. Presented in 11 chapters, the book focuses on the role of prebiotic fiber, hydrocolloids, fruit and vegetable by-product pomace and the physical, microstructural, sensory, and nutritional properties of the gluten-free pasta. The science of gluten intolerance is explained as well, with all relevant literature gathered and summarized in one place. Hence, this book lays a very solid foundation for the development of GF pasta which can be exploited as an essential therapeutic tool in the prevention of celiac disease. This comprehensive reference, written by world renowned scientists who elaborate on the study of different selected additives of plant origin, provides immense assistance in the field of research as many areas are still unexplored in the field of cereal science & technology.

Alzheimer's Disease and Advanced Drug Delivery Strategies compiles under a single volume the most recent advances in drug delivery to the brain as related to AD treatment. The book's editors recruited scientists from around the world to produce high quality chapters covering not only nanotechnological approaches, but also microsphere, niosomes, and liposomes. Among the topics covered are synthetic molecules, nobiletin, nose to brain delivery, natural biomaterials, cationic nanoformulations, dendrimers, microbubbles, and more. This book represents a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the brain.

Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics, Second Edition makes biochemistry lively, interesting and memorable by connecting objects, images and stories to biochemistry concepts. Here, Dr. Asha Kumari has converted cycles and difficult pathways into very simple formula and short stories and images to help readers see things in complicated cycles and better visualize biochemistry. As biochemistry is evolving steadily, with new and impactful topics, this new edition has been fully updated to include mnemonics on timely topics in biochemistry such as DNA replication, RNA, transcription, translation, and CRISPR technology, as well as fundamentals of immunity.

Dysphagia: A Clinical Guide will help practitioners and surgeons learn and understand how best to diagnose and treat dysphagia. It provides a complete picture of dysphagia through the experiences of leaders who cover the latest techniques and evidence-based outcomes in the field. Coverage includes recent advances in the diagnosis and treatment of the disease processes that cause dysphagia, gastric problems, and surgical intervention. The book includes the latest research and perspectives from both gastroenterologists and surgeons to enable clinicians to stay up-to-date on the most current and effective management strategies. Each chapter provides summary statements and recommendations based on recent literature. Recent discoveries regarding the diagnosis and management of dysphagia are exemplified by illustrations of both diagnostic methods and descriptions of interventional techniques. This an important reference for general surgeons, general practitioners, and ENT surgeons while also bringing new data dedicated specifically to gastroenterologists and foregut surgeons.

Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells. This two volume set is organized into four sections that address molecular mechanism underlying neuroprotection and neurotoxicity, neuroprotection mediated by natural molecules, neurotoxicity induced by natural compounds and nanotechnology-related strategies utilized in neuroprotection. Written by well-known researchers all over the world, chapters provide an in-depth analysis of numerous molecules, such as algae, plant and fungus-derived molecules, and comprehensively discuss their mechanisms of action and possible clinical applications. This set provides an essential reference for researchers and clinical scientists interested in the effects of natural compounds on the human health and disease.

Integrative Omics: Concept, Methodology and Application provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference provides systemic 'step-by-step' coverage that begins with basic concepts from Omic to Multi Integrative Omics approaches followed by applications and emerging and future trends. All areas of Omics are covered, including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics, technology policy, and society research. This book covers recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science.

Therapy Resistance in Prostate Cancer: Mechanisms and Insights, Volume 20highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and therapies that can be proposed to overcome resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa. Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide, as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies.

Colorectal Cancer: Disease and Advanced Drug Delivery Strategies examines the combined impact of basic clinical and medical treatments as well as recent advances in the field of colorectal cancer. With a strong focus towards colorectal cancer diagnosis, disease drug delivery, and diagnosis, the book also examines the Tumor microenvironment-responsive and site-specific nanoparticles for cancer theragnostics. Sections provide the opportunity to understand and diagnose the disease, describes screening methods, and update on drugs, including nano- and immunotherapy. Content includes clinical trials in colorectal cancer research and disease models that help better direct researchers and clinicians on how to diagnose and treat colorectal cancer.

Progress in Motor Control: From Neuroscience to Patient Outcomes updates the state-of-the-art of knowledge among scientists on basic and applied research on control of movements of biological systems through a clinical perspective. Motor control is a scientific area characterized by multidisciplinary approaches. This book promotes the application of this area into clinical practice. Chapters focus on topics in the field of motor control, including neural control of goal-oriented action, theories on rules of interaction during motor learning, and action coordination up to human and machine interaction. Edited by experts in the field, this book translates current theoretical outcomes into neuroscience and therapeutic solutions.

¿¿ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation sets out and critically discusses the current clinical and relevant preclinical ¿¿ T cell immunotherapy landscape. In five chapters, field experts discuss the challenges facing ¿¿ T cell oncoimmunotherapy, propose solutions, and map next steps. Particular attention is given to summarizing our understanding of the complex, translationally relevant human ¿¿ T cell biology, the evidence basis for designing ¿¿ T cell combination trials and data-driven perspectives on what is known-and what isn’t-about ¿¿ T cell therapeutic persistence. Various perspectives are provided on how issues of cytotoxic effector function, functional exhaustion, and cytokine addiction can be mitigated using gene engineering. A chapter is dedicated to the systematic review of all ¿¿ T cell immunotherapy trials to date, and the cell therapy products that were used in these trials. The final chapter discusses allograft persistence-enhancement techniques in the context of ¿¿ T cell therapy, covering lymphodepleting chemotherapy and synthetic stealth engineering. ¿¿ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation gives an updated and comprehensive insight into the current state of ¿¿T cell immunotherapy, which is of interest to existing translational ¿¿ T cell specialists, the proliferating range of academic scientists and commercial scientists entering the field, as well as clinicians who may encounter ¿¿ T cell immunotherapy in the clinic, or are wishing to familiarize themselves with noncanonical lymphocyte immunotherapy.

The prolific deployment of Artificial Intelligence (AI) across different fields has introduced novel challenges for AI developers and researchers. AI is permeating decision making for the masses, and its applications range from self-driving automobiles to financial loan approvals. With AI making decisions that have ethical implications, responsibilities are now being pushed to AI designers who may be far-removed from how, where, and when these ethical decisions occur. Trolley Crash: Approaching Key Metrics for Ethical AI Practitioners, Researchers, and Policy Makers provides audiences with a catalogue of perspectives and methodologies from the latest research in ethical computing. This work integrates philosophical and computational approaches into a unified framework for ethical reasoning in the current AI landscape, specifically focusing on approaches for developing metrics. Written for AI researchers, ethicists, computer scientists, software engineers, operations researchers, and autonomous systems designers and developers, Trolley Crash will be a welcome reference for those who wish to better understand metrics for ethical reasoning in autonomous systems and related computational applications.

Carbon-Based Nanomaterials in Biosystems: Biophysical interface at Lower Dimensions provides a thoroughly comprehensive overview of all major aspects of carbon-based nanomaterials, their biophysical response, and biotechnological applications. The book articulates the underlying physics, chemistry, and the basic phenomenon of the broad-range carbon-based nanomaterials (CNMs) with biological systems, particularly the interface analysis. Organized in six sections, it discusses state-of art technological interventions of carbon-based nanomaterials and their application in biomedical sectors in healthcare, food sciences, and technology. The book also highlights the carrying capacity of different CNMs in payload efficiency mechanisms in various biomedical fields. The theranostic efficiency and the safety of various forms of CNMs is assessed. This book will be a helpful resource to those specializing in the areas of nanomedicine, bionanomaterials, and nanotechnology applications.