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100 thoroughly revised coronal diagrams and accompanying photographic plates spaced at approximately 120 µm intervals 32 thoroughly revised sagittal diagrams and accompanying photographic plates 30 thoroughly revised horizontal diagrams and accompanying photographic plates Photographic plates printed from high resolution digital images in color The most accurate and virtually universally used stereotaxic coordinate system Over 800 structures identified Includes the Expert Consult eBook version, compatible with PC, Mac, and most mobile devices and eReaders, which allows readers to browse, search, and interact with content

Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies.

Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area. The book's chapters over the foundational aspects of pharmacogenomics, including drug metabolism, drug discovery, development, and testing, and then detail studies of key health conditions and the potential therapeutic applications of pharmacogenomics. Diseases covered include diabetes, cardiovascular diseases, psychiatric disease, cancer, pulmonary and respiratory diseases, viral diseases, gastroenterology, autoimmune diseases, immunosuppressants, and, finally, an overview of computational resources. This is the perfect resource for pharmaceutical science graduate students to learn the key concepts of the area. However, researchers and graduate students in the related fields of genetics, pharmacoepidemiology, molecular biology, and medicinal chemistry will also benefit from the structured approach of the book.

Annual Reports on NMR Spectroscopy, Volume 108, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

Advances in Child Development and Behavior, Volume 65, the latest release in this classic resource on the field of developmental psychology, includes a variety of timely updates, with this new volume presenting interesting chapters written by an international board of authors.

Discrete Mathematics provides key concepts and a solid, rigorous foundation in mathematical reasoning. Appropriate for undergraduate as well as a starting point for more advanced class, the resource offers a logical progression through key topics without assuming any background in algebra or computational skills and without duplicating what they will learn in higher level courses. The book is designed as an accessible introduction for students in mathematics or computer science as it explores questions that test the understanding of proof strategies, such as mathematical induction. For students interested to dive into this subject, the text offers a rigorous introduction to mathematical thought through useful examples and exercises.

Agrios' Plant Pathology, Sixth Edition is the ultimate reference in the field. Here, Dr. Richard Oliver provides a fully updated table of contents with revised and new chapters and invited contributors from around the globe. Building on the his legacy, this new edition is an essential read for students, faculty and researchers interested in plant pathology. Sections outline how to recognize, treat and prevent plant diseases and provide extensive coverage on abiotic, fungal, viral, bacterial, nematode and other plant diseases and their associated epidemiology. A large range of case studies take a deep dive into the genetics and modern management of several plant species.

Advances in Microbial Physiology, Volume 83 in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Topics of interest in this update include RidA paradigm, Targeting the cell envelope to overcome antimicrobial resistance, Biosynthesis and function of microbial methylmenaquinones, Antibiotic efficacy, Role of central metabolism/bacterial physiology on tolerance to cell wall-acting antibiotics, and Physiology of diazotrophs.

Advances in Immunology, Volume 158, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

Advances in Imaging and Electron Physics, Volume 227 in the Advances in Imaging and Electron Physics series, merges two long-running serials, Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy. The series features articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science, digital image processing, electromagnetic wave propagation, electron microscopy and the computing methods used in all these domains.

Advances in Clinical Chemistry, Volume 115, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists.

Advances in Agronomy, Volume 181, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, with each chapter written by an international board of authors.

Celiac Disease, Volume 179 in the Methods in Cell Biology series is composed of extensive protocols about novel and widely used techniques for celiac disease research. Topics covered in this volume include Pepsin trypsin digested gliadin treatment of intestinal cells in vitro, Ex vivo Gliadin Stimulation of Intestinal Cells, Measuring intestinal permeability in celiac disease ex vivo using Ussing chambers, Intestinal permeability assessment using lactulose and mannitol, In vivo sensitization to gliadin by oral administration, Separation of epithelial and immune cells from intestinal biopsy samples, Isolation and study of dendritic cells and macrophages from human intestinal samples, Gnobiotic mouse models to study gluten sensitivity, and more. Other sections in this new release include In vitro differentiation of macrophages from peripheral blood cells of celiac patients, Assessment of activated gut-homing CD8+ T cells in blood by flow cytometry during a three-day gluten challenge, Isolation, cryopreservation and thawing of peripheral blood mononuclear cells for downstream applications, and more.

COVID-19: Implications for Policy and Planning, Volume Eleven in the Advances in Transport Policy and Planning series, highlights new advances in the field, with this new volume presenting interesting chapters on valuable topics such as the Impact of COVID-19 on teleworking, Retail after COVID: Impacts on accessibility, Equity implications of older adults' mobility in South Asia in the aftermath of COVID-19: A conceptual framework and literature review, COVID-19 and public transport response and challenges, Outlining the window of opportunity for the low carbon transition in transport: A review of impacts on walking practices in the COVID-19 pandemic, and much more. Additional sections cover the Impact of COVID-19 on micromobility, Examining the impacts of the COVID-19 pandemic on ride-sourcing services: Findings from a literature review and case study, COVID-19 and long-distance travel, and much many policy and planning considerations.

Dietary Lipids: Nutritional and Technological Aspects, Volume 105 focuses on major dietary lipids and their minor bioactive compounds, also covering the role of these lipids in metabolic diseases and covering oil processing with clean technologies and lipidomic characterization by mass spectrometry. Specific chapters in this new release include Major Dietary Lipids in Nutrition and Health, Minor bioactive lipids, Cleaner Processing for Lipids: Supercritical Fluid Extraction and Short Path Distillation, Nutritional Lipidomics for the Characterization of Lipids in Food, We are what we eat? The Role of Lipids in Metabolic Disease, Lipid Emulsions in Clinical Nutrition: Enteral and Parenteral Nutrition, and much more.

Imaging in Virus Research, Volume 116 in the Advances in Virus Research series highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics of interest in this release include Recent developments of advanced fluorescence microscopy methods for biological applications, Fluorescence microscopy to image virus entry: Probing different angles, RSV and cytoplasmic inclusion bodies, Advanced Imaging of HIV-1 fusion and virus-host lipid interactions, Spatiotemporal orchestration of virus morphogenesis, Imaging applied to study interactions between poxviruses and their host cells, Viral capsid structures, Tissue Clearing and 3D-Imaging of Virus Infections, and much more.

Modifications and Targeting of Protein Termini, Volume 684 in the Methods in Enzymology series serial highlights new advances in the field, with this new volume presenting interesting chapters pn a variety of timely topics, including Optimizing purification and activity assays of N-terminal methyltransferase complexes, In vitro reconstitution of hierarchical steps of Arg/N-degron pathway, Identification of N-degrons and N-recognins by using peptide-pull-downs combined with quantitative proteomics, A decoupled Virotrap approach to study the interactomes of N-terminal proteoforms, Monitoring ADO-dependent proteolysis in cells using fluorescent reporter proteins, Site-specific a-N-terminal methylation on peptides through chemical and enzymatic methods, and more. Additional sections cover Monitoring the interactions between N-degrons and N-recognins of the Arg/N-degron pathway, Characterization and chemical modulation of p62/SQSTM1 as an autophagic N-recognin of the Arg/N-degron pathway, Analysis of higher plant N-degron pathway components and substrates via expression in S. cerevisiae, and so much more.

Non-Conventional Starch Sources: Properties, Functionality, and Applications presents the use of non-conventional, unutilized, and underutilized sources to isolate, characterize and functionalize starches. Specific attention is paid to the sources' application in foods as well as their incorporation into packaging through films and coatings. Broken into seven sections, this book addresses sources from fruit seeds, cereals and millets, pseudo-cereals, seeds, roots and tubers, rhizome and legumes. Food scientists, technologists and students and researchers studying related fields will benefit from this important reference.

Techniques for Downstream process for Biologic Drugs and Vaccines provides comprehensive technologies involved in processing postharvest broth to separate the target biological therapeutic products of extracellular or intercellular aspects in nature - to its highest purification form, and to thus make it acceptable to end users. The technologies involved in the post-harvesting of fermented broth are explained in this comprehensive resource in a simplified manner with different case studies to help non-engineering students and scientists easily capture the basic principle of biomass processing technologies and their applications in new projects related to the development and manufacturing of therapeutic bio-products. As conceptual development of biotechnology has taken new shape and style with the integration of medical sciences, physical science, and engineering, and has thus begun the need for the development of microbial or cell line process technology and application for large-scale isolation and purification of metabolites or vaccines through the fermentation process, this book covers the most important aspects.

Entrepreneurship with Microorganisms explains both the basic science and applications of microbiology and bio-resource technology, shining a special emphasis on its entrepreneurial applications. By focusing on basic principles, current research, and global trends, this comprehensive book provides a critical resource and serves as a complete one-stop source for undergraduate and graduates in microbiology, food, agricultural science, medical science, and industrial microbiology biotechnology. In addition, this book will be helpful in the creation of economic (commercial) value of the microorganism(s) based products and technologies as well as opportunities for new jobs at the global level.

The COVID-19 Response in New York City: Crisis Management in the Largest Public Health System provides an historical accounting of the response to the COVID-19 pandemic through the eyes of the largest public health system in the United States. The book offers a roadmap to guide healthcare systems and their providers in the event of future pandemics. Readers will learn about surge staffing and level loading, as well as tips from the ED and ICUs on how to respond to an unprecedented influx of inpatients. Written by healthcare providers who were at the epicenter of the pandemic in New York City, this book provides a sound accounting of the response to the pandemic in one of the world's largest cities.

Inoculating Cities: Case Studies of the Urban Response of the COVID-19 Pandemic uses detailed case studies to document and describe how cities located in high, middle and low-income countries responded to the COVID-19 pandemic. City governments and municipal authorities exist and operate in extremely varied contexts (i.e., socioeconomic, demographic, legal and governance, etc.) and intentionally documenting the experiences in these different contexts provides guidance to decision-makers for future preparedness and response activities. This volume highlights the innovative solutions throughout the pandemic as described by the people who designed and implemented pandemic response efforts in their cities. In addition, it identifies successful models that can be adopted in the future by city leaders around the world.

Vegetable Oil Based Polymers and Their Surface Applications presents detailed coverage of principles, preparation methods and novel surface uses of vegetable oil based polymers. This comprehensive, state-of-the-art book follows the journey of vegetable oils from seeds to surfaces in a range of advanced applications. Opening chapters discuss theory, principles and characterization techniques while other sections present concepts on the preparation of different polymer types based on vegetable oil. The final section of the book provides extensive coverage of applications, enabling the preparation of vegetable oil based polymers for a range of products and industries. This is a valuable resource for researchers, scientists, and advanced students in polymer chemistry, surfaces and coatings, natural polymers, materials chemistry, chemical engineering and plastics engineering. In an industrial setting, this book supports R&D professionals, scientists, and engineers interested in developing innovative biobased materials for a range of applications, including automotive and aerospace, packaging, cosmetics, pharmaceuticals, biomedicine and consumer goods.

Senescence and Mitochondria Targeted Senotherapeutics, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more.