Bøger udgivet af Elsevier Science Publishing Co Inc

The coronavirus pandemic that began in 2019 brought to the fore the presence of a significant minority of individuals who strongly oppose vaccination. This opposition is by no means recent. Ever since the very first attempts to immunize individuals, opposition has been intense in some societies. The reasons for this opposition range from religious to political to medical. Although vaccines have eliminated smallpox and largely eliminated polio and measles, opposition to vaccination persists and,  in some countries, has grown stronger. A History of Vaccines and Their Opponents seeks to describe the history of this opposition as well as its changing rationale over the years and in different societies. The discussion may ultimately provide some suggestions for reducing hesitancy in the future.

Recent Advances in Nanocarriers for Pancreatic Cancer Therapy reviews thriving strategies concerning pancreatic cancer therapy, thoroughly describing the most recent developments in emerging modern drug delivery systems focused on, and derived from, nanotechnology. By providing a holistic understanding of the molecular pathways, conventional therapy and novel nanocarriers mediated drug delivery against pancreatic cancer, this work can be considered a complete package. The book offers a solution to the dissemination of data from a broad range of resources by providing an overview of the molecular pathways and conventional therapy of pancreatic cancer, the application of various nanocarriers, and more. This book equips scientists, clinicians and students to make rational treatment approaches based on nanomedicine for improving and extending the human life against pancreatic cancer.

Pharmaceutical Biotechnology in Drug Development summarizes key concepts and the latest developments of biotechnology applied to the development of biopharmaceuticals. Chapters present a comprehensive collection of introductory biotechnology technologies and their modern concepts and cover pharmacokinetic and pharmacodynamic behavior of biopharmaceuticals and modification techniques of amino acids and nucleic acid. Other sections focus on topics such as gene therapy, immunological preparations and nanoparticles which are the major contributions of pharmaceutical biotechnology. Final chapters discuss emerging techniques in the field of pharmaceutical biotechnology to meet current patient and health care demand. This book is an essential reference useful for pharmaceutical scientists, clinicians and academic researchers who want easy access to up-to-date practices of pharmaceutical biotechnology. Corporate researchers will also benefit from this book's succinct and objective content structure.

Ocular Aging: Impact on the Eye provides an integrated description of the latest research findings on aging affecting ocular structures, discussing clinical characteristics of several sight-threatening disorders with detailed descriptions of clinical features and therapeutic options. Written by experts, each chapter covers the impacts of aging on specific ocular structures and integrates this information with the most common ocular disorders that are significantly dependent on age. This unique approach makes this book an invaluable source of reference for researchers interested on the latest research findings and ophthalmologists looking for a description of clinical features and therapeutic options for several age-related disorders.

Precision Agriculture: Evolution, Insights and Emerging Trends presents a complete guide from foundational concepts to the economic, commercial and environmental implications of the approach. Showcasing recent research improvements, future trends, and highlighting innovative use of machine vision, artificial intelligence, UAVs, drones, IoT and data analytics to promote sustainable agriculture, the book brings the reader up-to-date with understanding and implementing this targeted practice. From the basic elements of agronomy to insights on reflectance and remote sensing indices, chapters use summary abstracts, case studies and real-world examples of implementing the tools of precision agriculture (PA) to demonstrate the latest advances. It includes explanations on the origin of the intra-plot variability of a culture (spatial and temporal), different types of existing sensors, controllers and site-specific management. The book further explores yield monitoring, weed, disease and pest control, automated irrigation systems, PA tools for variable rate application of inputs within the field, and data processing methods. By also exploring the economic profitability of precision farming approaches, and its utility for sustainable agriculture, Precision Agriculture: Evolution, Insights and Emerging Trends is a truly comprehensive view of this important approach to improving global agriculture production. Scientists, researchers, policymakers, graduate and postgraduate students, and engineers in the related fields of agriculture, computer science and engineering will benefit from this book.

Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how, and why genomic surveillance may be applied. Drawing heavily from the learnings during the COVID-19 pandemic, this book covers different aspects of microbes with a focus on viral genome sequencing and analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation evolutionary dynamics, RNA modulation of infection, pathogen diversity, and the role of coinfections and comorbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent COVID-19 analysis, are discussed. Finally, the authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines. Throughout this book, importance is placed on inference‿moving from genomic sequencing to meaningful genomic surveillance that bolsters pandemic preparedness.

Yasargil Microneurosurgery Study Guide is designed for effective learning and study of the neurosurgical principles contained in seminal microneurosurgery textbooks. From normal microsurgical anatomy to aneurysms, arteriovenous malformations, and CNS tumor microsurgery, this study guide provides a question-and-answer format to knowledge of the background, anatomy, and techniques of microneurosurgery. This work is a practical guide to the application of microneurosurgery to a variety of brain conditions, including intracranial aneurysms, extrinsic and intrinsic tumors, while providing guidance on instrumentation and equipment, neuroanesthesia, complications, and more. This practical book is ideal for neurosurgeons, neurologists, neuroanatomists, and other technical experts with a clinical interest in brain microsurgery.

Medical and Healthcare Robotics: New Paradigms and Recent Advances provides an overview and exclusive insights into current trends, the most recent innovations, and concerns in medical robotics. The book covers the major areas of medical robotics, including rehabilitation devices, artificial organs, assistive technologies, service robotics, and robotic devices for surgery, exploration, diagnosis, therapy, and training. It highlights the limitations and the importance of robotics and artificial intelligence for medical and healthcare applications. The book is a timely and comprehensive reference guide for undergraduate-level students, graduate students, and researchers in the fields of electrical engineering, mechanical engineering, mechatronics, control systems engineering, and biomedical engineering. It can be useful for master‿s programs, leading consultants, and industrial companies. The book can be of high interest for physicians and physiotherapists and all technical people in the medical and biomedical fields.

Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.

Textile reinforcement forms (preforms) play an important role in determining the properties of the final composite and product. The preform formation process provides precise control of the fiber architecture and orientation using a suitable textile manufacturing technique. While the techniques employed for preparing glass and carbon preforms are well-known, there is still a gap in understanding on how to prepare natural preforms for composite reinforcements. Multiscale Textile Preforms and Structures for Natural Fiber Composites will bridge this gap by presenting unified knowledge on the relevant preform preparation techniques and resulting fiber architectures. Emphasis is on the structural parameters of each preform and their effect on the final composite properties. This book assembles information and knowledge on natural fiber reinforcement forms, including conventional forms, such as spun yarn, woven, knitted, nonwoven, braided, and comingled. These are illustrated and classified into one-, two-, and three-dimensional reinforcements. This book also includes information on nonconventional preform formation techniques such as unidirectional tapes, pre-impregnated preforms, spread tows, and tailored fiber placement.

Anesthesia and Analgesia in Laboratory Animals focuses on the special anesthetic, analgesic and postoperative care requirements associated with experimental interventions. Fully revised and updated, this new edition provides the reader with agents, methods and techniques for anesthesia and analgesia that ensure humane, reproducible, and successful procedural outcomes. Sections cover ethical, regulatory and scientific considerations, principles of anesthesia and analgesia, anesthetic equipment and monitoring, periprocedural care, including dedicated chapters to the assessment and management of pain in laboratory species, and practical considerations by species, including relevant anatomy, physiology, and behavior of a broad range of lab animal species. This will be a complete reference for veterinarians involved in lab animal research as well as senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research.

Electricity Cost Modeling Calculation: Regulations, Technology, and the Role of Renewable Energy, Second Edition delivers an updated view on pricing models, regulation, technology and the role renewable energy is starting to take in electricity. Starting with fundamental concepts on market structure and the increase in international regulations, the book includes cubic cost modeling cases and updated literature reviews for deeper research. Other sections cover more advanced quantitative methods such as load forecasting, updated rate designs, and the marginal cost of electricity in the United States. Includes applications will help reduce greenhouse gas emissions, thus making the reference relevant for today''s power markets. This book gives today''s engineers a practical guide on the latest techniques in electricity pricing and applications for today''s markets. Provides readers with updated, international regulations and the role of renewable energy sources Bridges the gap between foundational concepts and advanced quantitative aspects, including updated practical case studies Helps readers understand the appropriate rate/tariff structure for efficient use of electricity and renewable options

Molecular Biology, Third Edition, provides a thoroughly revised, invaluable resource for college and university students in the life sciences, medicine and related fields. This esteemed text continues to meet the needs of students and professors by offering new chapters on RNA, genome defense, and epigenetics, along with expanded coverage of RNAi, CRISPR, and more ensuring topical content for a new class of students. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves. Moreover, as part of the Academic Cell line of textbooks, this book contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles form the basis of case studies found in the associated online study guide that is designed to tie current topics to the scientific community. Winner of a 2020 Textbook Excellence Award (College) (Texty) from the Textbook and Academic Authors AssociationContains new chapters on non-coding RNA, genome defense, epigenetics and epigenomicsFeatures new and expanded coverage of RNAi, CRISPR, genome editing, giant viruses and proteomicsIncludes an Academic Cell Study Guide that ties all articles from the text with concurrent case studies Provides an ancillary package with flashcards, online self-quizzing, and PowerPoint slides with images

Offers a collective term for all systematic practices to minimize and control quantity and cost of energy used in providing a service. This title provides paradigms for measuring energy sustainability, pragmatic methods for applying renewable resources and efficiency improvements, and insights on managing risk in power production facilities.

By proposing innovative concepts, theorems and algorithms, this book helps to bring the cost down for both cloud users and service providers to run computation and data intensive scientific applications in the cloud. It describes several novel strategies for storing application datasets in the cloud.

Offers insights in energy efficient building from the world over, providing a multi-faceted overview of the energy efficient architecture. This title covers issues as daylighting, LED lighting, integrating renewables such as solar thermal and cooling, LEED and similar certification efforts, net-zero and close-zero structures, and more.

Presents an introduction to the phenomena of ultra short laser pulses and describes how this technology can be used to examine problems in areas such as electromagnetism, optics, and quantum mechanics.

**Association of American Publishers (AAP) PROSE Award Finalist in Mathematics and Statistics, 2024** Probability and Statistics for Cereals and Grains: A Guide to Measurement and Analysis is a guide to help technical people be more efficient users of statistics. Author Terry C. Nelsen uses examples from his 35-plus years of experience in the field and presents the appropriate statistics and graphics to use when evaluating data. Researchers, academicians, students, technicians, processors, laboratory personnel, and those working in QA/QC will benefit from this much needed reference.

Coal and Coalbed Gas: Resilient Resource: Fueling the Future, Second Edition provides the latest research and advances, highlighting shifting trends of coal use and remaining resiliency on 'a tale of two worlds,' one half (West Europe, North America) moving away for cleaner energy sources and the other half (Asia-China-Pacific region, East Europe, South America) upping coal demand as an affordable energy source. The book emphasizes coalmine gases (CMM and AMM) as equally important as coal-fired power plants CO2 emissions as sources of potent anthropogenic greenhouse gas (GHG) prioritized for capture, use and storage and underscores R&D of emerging non-fuel uses towards coal-to-carbon-based products.Each chapter in this book is fully updated, with two new chapters covering the global occurrence of coal, the environmental impact of coal and coalbed gas use, and alternative, non-fuel uses of coal.

Breeding Disease-Resistant Horticultural Crops is a complete and comprehensive resource for understanding the concept of breeding disease resistant crops, especially horticultural crops. Breeders of horticultural crops face distinct challenges that are different from agronomy/row crops, and these crops do not benefit from the vast body of literature available for agronomic crops. This book covers the basic theories that underpin breeding for disease resistance and features extensive real-world examples. Both classical and biotechnical breeding methods are covered, with an emphasis on how these methods are adapted for horticultural species. Presented in a logical flow for the reader, this book addresses historical perspectives and context as it relates to breeding for disease resistance. It highlights treatments of resistance in the context of the phenotype, the genotype, the pathogen, the environment interaction, sources of resistance, and the deployment of resistance to obtain a durable resistance.