Bøger udgivet af Elsevier Science Publishing Co Inc

Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.

New Aspects of Meat Quality, Second Edition continues to be the leading source of scientific information for what constitutes meat quality for consumers, marketers and producers in the 21st century. The book includes traditional measures of meat quality such as texture, water holding, color, flavor/aroma, safety/microbiology and processing characteristics as well as quality assurance schemes, organic/free range, ethical meat production, and the desirability of genetically modified organisms, amongst others. Users will find comprehensive coverage on developments in our understanding of how muscle structure affects the eating qualities of cooked meat, along with techniques for measuring, predicting and producing meat quality. In addition, the book covers how these new techniques help us minimize variability in eating quality and/or maximize value. The book's final section identifies the current qualities of consumer and public perceptions and what is sustainable, ethical, desirable and healthy in meat production and consumption.

Sex and Cohabitation Among Early Humans: Anthropological and Genetic Evidence for Interbreeding Among Early Humans explores the available information regarding interbreeding among different ancestral human species. In addition, it reviews evidence in support of cohabitation as well as cultural and technological interactions and exchanges among early humans, particularly Neanderthal-sapiens interactions. The fields of archaeology, anthropology, genetics, linguistics and molecular evolution have provided a wealth of information on the complex processes involved in human evolution. The book will help readers will develop knowledge on the complexity and multiplicity of hominins, including Homo heidelbergensis, Homo sapiens, and Homo floresiensis. Moreover, the book will help them reach a greater understanding of major topics, such as introgression, migration from Africa, the origin, development and extinction of Neanderthals, interbreeding between Neanderthals and humans, and trait continuity.

"The Belt and Road initiative is marketed by the Chinese government as the 'twenty-first century maritime Silk Road' and the 'Silk Road economic belt'. The initiative encourages policy coordination, trade facilitation, financial integration, and transport connectivity. The Belt and Road initiative covers at least 65 countries across Asia, Africa, the Middle East, and Europe, involving 70% of the global population, 75% of world energy reserves and 55% of world GNP. Such an initiative is expected to bring significant impacts to the transport and logistics industry in the regions involved. The transport and logistics sector not only directly contributes to the production of transport and logistics services, but also provides essential inputs to other sectors such as tourism, trade, infrastructure investment and management. Therefore, it is important to jointly analyse the implications of the Belt and Road initiative to the transport and logistics sectors, the best strategies and operation practices that the industry can pursue, and the right government policies that should be implemented in relation to the initiative."--

Alkali-activated materials, including geopolymers, are being studied at an increasing pace for various high-value applications. The main drivers for this emerging interest include the low-energy, low-cost, and readily up-scalable manufacturing process; the possibility to utilize industrial wastes and by-products as raw materials; and beneficial material properties comparable to conventional materials. It has already been verified that alkali-activated materials are very versatile in environmental technology applications for pollution control. The current research in the field focuses on advanced manufacturing methods, material properties, and applications, for example, additive manufacturing, modification of surface chemistry, CO2 capture, and green catalysis. Alkali-Activated Materials in Environmental Technology Applications discusses what novel possibilities alkali-activated materials provide in comparison to conventional materials (such as high-temperature ceramics, synthetic zeolites, or organic polymers). The specific environmental applications that are covered include water and wastewater treatment, air pollution control, stabilization/solidification of hazardous wastes, and catalysts in chemical processes. In addition, preparation methods, material properties, and the chemistry of alkali-activated materials are revisited from the viewpoint of environmental technology applications. This book also discusses how well alkali-activated materials fit under the concepts of green chemistry and circular economy and how the life cycle analysis of these materials compares to conventional materials.

Revised edition of: Groundwater ecology / edited by Janine Gibert, Dan L. Danielopol, Jack A. Stanford. c1994.

Phase Change Materials-Based Photonic Computing provides a clear introduction to the field, introducing concepts of photonics, computing, phase change materials and future outlooks. Phase change materials are well known and studied in many contexts, and photonics is a longstanding field, with photonic neuromorphic computing recently gathering interest. However, the two fields are disparate and few people understand the key concepts needed to integrate the two. This book will be the first to do so in this promising field. It is suitable for researchers and practitioners in academia and industry working in the disciplines of materials science and engineering, electrical engineering and computing.

Salivary Biomarkers for Oral and Systemic Diseases contains contributions from a number of experts and highly regarded scientists and clinicians. This book offers unique insights into the science of biomarkers in oral diseases and how to use biomarkers to help in the diagnosis of both oral and systemic diseases. The book focuses on all oral fluids, such as GCF, peri-implant fluid, and whole mouth saliva, and outlines the practical importance of the use of other biological samples from the oral cavity. This is a must-have reference for all those interested in salivary biomarkers across the bioscience and biomedical fields.

Essential reading for researchers, practitioners, and engineers, this book covers not only all the important aspects in the field of corrosion of steel reinforced concrete but also discusses new topics and future trends. Theoretical concepts of corrosion of steel in concrete structures, the variety of reinforcing materials and concrete, including stainless steel and galvanized steel, measurements and evaluations, such as electrochemical techniques and acoustic emission, protection and maintenance methods, and modelling, latest developments, and future trends in the field are discussed.

Power Transformer Online Monitoring using Electromagnetic Waves explores how to use electromagnetic wave technology and remote monitoring systems to predict and localize costly mechanical defects and partial discharge challenges in high voltage transformer windings. This innovative approach brings several potential benefits compared with conventional techniques such as frequency response analysis, including impermeability to ambient noise, and online implementation capability. This book reviews both fundamental and state-of-the-art information about all key aspects of condition monitoring using electromagnetic waves. It addresses the simulation of power transformers in CST environment while also explaining the theoretical background of boundary conditions used. Chapters review how to achieve practical online implementation, reliable diagnosis, asset management and remnant life estimation. Partial discharge detection is also discussed.

PDE Modeling of Tissue Engineering and Regenerative Medicine: Computer Analysis in R presents the formulation and computer implementation of mathematical models for the forefront research areas of tissue engineering and regenerative medicine. The mathematical model discussed in this book consists of a system of eight partial differential equations (PDEs) with dependent variables. The computer-based example models are presented through routines coded in R-a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Includes detailed examples that the reader can execute on modest computers.

The COVID-19 pandemic represents an important watershed for modern society. The world will never be the same. Almost all economic and social activities need to be reviewed, rethought, and adapted to the new context. The COVID-19 Disruption and the Global Health Challenge explains a complex phenomenon that has left doubts and uncertainties among the many who want to understand. The book fills some of these gaps by providing answers to a series of questions including why the epidemic originated, how it spread, how it was managed, how long we will have to live with it, what effects did it have on the economy, who will be most affected, how the new world will change us, and how our way of seeing the world will change. Lastly, the book proposes some solutions to prevent and be more prepared to the recurrence of such events as well as to manage them more effectively.

Nanotechnology for Civil Infrastructure: Innovation and Eco-efficiency of Nanostructured Cement-Based Materials explores recent innovations in civil infrastructure materials developed through nanotechnology. The book covers cementitious materials containing nanomaterials, covering their design, characterization and applications. The book also covers the possibilities to optimize properties such as rheological properties, mechanical strength, durability and resistance to aggressive environments and loads, and eco-efficiency. Final sections explore the integration of nanomaterials in cement mixtures that lead to nanocomposites with novel properties, such as self-healing, self-sensing, and self-cleaning, and featured applications in civil infrastructure.

Quality Assurance Management: A Comprehensive Overview of Real-World Applications for High Risk Specialties demonstrates how to best design and implement standard operating procedures (SOPs) to ensure protocol and regulation adherence. The book showcases similarities and differences between healthcare and academic quality assurance systems, resulting in counter-productivity and performance issues, in addition to regulatory inspection preparedness. It uses the processes and standards of the UK to demonstrate how to combine QA and research building into 'building blocks' that share a common pathway for effective project design, analysis and unbiased interpretation of collated data.This book fills a gap, providing original research in QA that especially focuses on specialist areas. It will be of use to research and clinical staff working in clinical research within healthcare, academia and industry.

Advances in Geophysics serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Advances in Geophysics serials Updated release includes the latest information on geophysical exploration of the solar system

Metals in Water: Global Sources, Significance, and Treatment covers metal pollution in water, where they come from, their effects, and remediation processes. Sections overview heavy metals pollution, including their global health impacts and remediation measures. Geogenic and anthropogenic input of heavy metals in water are described, along with global case studies, step-by-step methods on remediation techniques, different detection sensors, and assessment practices of toxicity of heavy metals. The book focuses on recent research surrounding heavy metals' contamination in water resources and its impact across the globe. Chapters incorporate both theoretical and practical aspects and serve as baseline information for water resources studies. This book is useful for postgraduate students, teachers and researchers working in areas of water resources and pollution, hydrochemistry, environmental remediation and toxicology who are looking to understand the affects metals have on water, the environment and health, and also those looking for methods for remediation.

Plastics and Sustainability: Practical Approaches provides a broad overview of sustainability as applied to plastics, offering a range of opportunities and solutions to be applied in an academic or industrial setting. The book begins by introducing the challenges and opportunities relating to plastics and environmental sustainability. This is followed by detailed eco-profiles organized by polymer category. Subsequent chapters explore various approaches to plastics sustainability, with in-depth coverage of incineration technology for energy recovery, pyrolysis for chemical recovery, blending technology, design, packaging, circular economy, and biopolymers. Finally, international policies are summarized. The book aims to provide a broad source of information and a range of options to readers on how to evaluate and improve the sustainability of plastics, with analyses of the advantages and drawbacks of different technologies and materials. Authored by two professional engineers with substantial experience in industry and consultancy, this is a valuable resource for all those looking for a wide-ranging overview of sustainability as applied to plastics, including researchers and advanced students from a range of materials science and engineering disciplines, and engineers, manufacturers, scientists, and R&D professionals from a range of industries.

Motion Correction in MR: Correction of Position, Motion, and Dynamic Changes, Volume Eight provides a comprehensive survey of the state-of-the-art in motion detection and correction in magnetic resonance imaging and magnetic resonance spectroscopy. The book describes the problem of correctly and consistently identifying and positioning the organ of interest and tracking it throughout the scan. The basic principles of how image artefacts arise because of position changes during scanning are described, along with retrospective and prospective techniques for eliminating these artefacts, including classical approaches and methods using machine learning. Internal navigator-based approaches as well as external systems for estimating motion are also presented, along with practical applications in each organ system and each MR modality covered. This book provides a technical basis for physicists and engineers to develop motion correction methods, giving guidance to technologists and radiologists for incorporating these methods in patient examinations.

Encyclopedia of Sensors and Biosensors, Four Volume Set provides unique foundational level information on the rapidly growing sensor community. The book covers innovations in materials, designs, devices and software that find their way into new types of sensors. Sections include over 1000 color images, including representations of sensor design, sensor manufacturing, and assessments of sensor performance. In addition, applications of sensors in healthcare, food safety, environmental engineering and other fields are discussed, making this a truly interdisciplinary work. The book is structured using a logical and thematic approach, with chapters taking a balanced viewpoint, listing both advantages and disadvantages. Perfect for those learning their trade in both academia and industry, this vital reference work will serve many groups, including chemists, engineers, biological scientists, clinicians, and industrial researchers.

Clinical Trials and Tribulations evaluates the multiple layers of complexities around research management, also exploring current practices, challenges and future directions. The book provides answers to readers questions and problems through extensive use of real-world examples, case studies and lessons learned. Following an approach to provide pragmatic viewpoints as well as concepts and methodologies and its alignment with specific practices, the book explores paradigms between planning and conducting research in academia vs. healthcare vs. industry in the UK vs. Europe vs. America. It highlights practical solutions to real-world complex issues that have been documented by independent regulators. This will be an indispensable book for all staff working in clinical research within healthcare, academia and industry, as well as students intending to work in clinical trials.