Bøger udgivet af Elsevier Science

Learning Deep Brain Stimulation Management through Clinical Cases reviews the clinical practice of applying deep brain stimulation (DBS) to patients with movement disorders. The book explores the cardinal aspects of applying DBS in diverse movement disorders based on patient’s needs. Every case answers all questions, providing case descriptions and step-by-step procedures for optimal replication. Every chapter includes a clinical decision support system (CDSS) depicted in flowcharts that can be used for reference. Deep Brain Stimulation (DBS) uses electrical stimulation to regulate electrical signals in neural circuits to and from identified areas in the brain to improve movement symptoms. The management of DBS in a movement disorders can be challenging, optimizing patient journeys and grasping all clinical aspects of the highly technological therapy. Hence, this book provides the informaiton necessary to embrace new breakthroughs.

Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.

Intelligent Fractal-Based Image Analysis: Application in Pattern Recognition and Machine Vision provides insights into the current strengths and weaknesses of different applications as well as research findings on fractal graphics in engineering and science applications. The book aims to improve the exchange of ideas and coherence between various core computing methods and highlights the relevance of related application areas for advanced as well as novice-user application. The book presents core concepts, methodological aspects, and advanced feature opportunities, focusing on major, real-time applications in engineering and health science. It will appeal to researchers, data scientists, industry professionals, and graduate students. Fractals are infinite, complex patterns used in modeling physical and dynamic systems. Fractal theory research has increased across different fields of applications including engineering science, health science, and social science. Recent literature shows the vital role fractals play in digital image analysis, specifically in biomedical image processing. Fractal graphics is an interdisciplinary field that deals with how computers can be used to gain high-level understanding from digital images. Integrating artificial intelligence with fractal characteristics has resulted in new interdisciplinary research in the fields of pattern recognition and image processing analysis.

Drug-delivery Systems of Phytochemicals as Therapeutic Strategies in Cancer Therapy elucidates the importance of various phytochemicals in cancer therapy and explains various routes/methods to deliver phytochemicals for overcoming the problems associated with delivery systems in cancer treatment. Several nanotechnological methods are presented to enhance drug solubility, sustainability, bioavailability, and gastrointestinal permeability of these phytochemicals. Current understanding of the relevant information presented on therapeutic strategies in cancer therapy fulfils the requirements of oncologists, molecular biologists, pharmacologist and related researchers who want to work in the areas of drug development targeting phytochemicals for cancer therapy.

Spinel Materials: Synthesis, Characterization, and Applications reviews the key principles, methods, applications, and research directions of spinel materials. Fundamental aspects such as the relationship between their size, metal ion occupancy, and physical behavior are introduced. Then, the synthesis methods to produce these materials and characterization methods used to observe their behaviors are reviewed. The electronic, optical, and magnetic properties of spinel materials make them suitable for wide range of uses, but especially for energy applications. The book reviews the most relevant opportunities and challenges of the use of spinel materials for energy applications.This resource is suitable for researchers and practitioners working in the subject area of materials science and engineering, and may also be of interest to those working in chemistry or physics disciplines.

Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration is a comprehensive reference that covers all vistas of standardization of axon regeneration, as well as all multi-omics and system level data and integration tools. By adopting a translational approach, the book bridges current research in the field to clinical applications, and readers can expect to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, multiple dataset integrative tools, pathway convergence approaches and tools, outcome and outcome measures that unify bench research with clinical outcome. The axon regeneration from existing neurons in central nervous system (CNS) have become a potential possibility in the last decade. The potential possibility of long-distance axon growth has opened the possibility of re-connectivity of axons of retinal ganglion cell neurons within the lateral geniculate nucleus in the brain. The long-distance axon regeneration and re-connectivity is a promise to restore lost vision in the optic nerve. Further, long-distance regeneration and re-innervation is equally helpful for other fields such as spinal cord injuries.

The field molecular pathway analysis evolves rapidly, and many progressive methods have recently been discovered. Molecular Pathway Analysis Using High-Throughput OMICS Data contains the largest collections of molecular pathways. For the first time, guidelines on how to do genomic, epigenetic, transcriptomic, proteomic, and metabolomic data analysis in real-world research practice are given. Molecular Pathway Analysis Using High-Throughput OMICS Molecular Data also focuses on the pathway analysis applications for solving tasks in biotechnology, pharmaceutics, and molecular diagnostics ¿¿It demonstrates how pathway analysis can be applied for the research and treatment of chronic and acute diseases, for next-generation molecular diagnostics, for drug design and preclinical testing; relevant real-world examples, molecular tests, and web resources will be reviewed in-depth.¿ ¿¿The book shows a tendency of erasing the borders between chemistry, physics, informatics, mathematics, biology, and medicine by means of novel research approaches and instruments, providing a truly multidisciplinary approach.

Hybrid Polymeric Systems for Biomedical Applications explores the development and utilization of hybrid polymeric systems for use in a range of biomedical applications. Hybrid systems combine the specialized properties of each polymer type to produce a more targeted material which is much more tightly aligned with the intended application and outcome. This book covers a broad selection of hybrid polymeric systems as well as a variety of key biomedical applications, including tissue engineering, drug delivery, wound healing, and more.

Technical Organic and Inorganic Fibres from Natural Resources focuses on recent advances in the synthesis, processing, characterization, and application of non-textile fibers. The book provides a general introduction to the uses of natural fibers in technical textile applications while also reviewing the latest technical methods for producing these high-performance materials. As the textile industry is focused on finding alternative green fibers with the aim of providing high quality products which are fully recyclable and biodegradable, natural fibers from renewable sources play an increasingly important role in the industry due to their unique properties and functionality.

Cancer Therapy: Potential Applications of Nanotechnology provides readers with a compendium of all the latest research work in cancer therapeutics, including an emphasis on work in nanotechnology and polymeric nanoparticles. While there have been a large number of ongoing research projects and publications on the treatment of cancer, there is a limited number of books related to nanotechnology, especially those with an emphasis on polymeric nanoparticles in cancer therapy. This title enlightens researchers and students and provides exhaustive knowledge on the topics covered.

Self-powered Sensors: A Path to Wearable Electronics features recent developments in chemical, photonic, pharmaceutical, microbiological, biomimetic, and bio-inspired approaches for MEMS/NEMS and medicinal self-powered sensors. Unconventional nanomaterial sensors driven by self-sufficient energy are given a contemporary review, with a focus on the categorization of energy sources and comparisons of research involving self-powered solar, piezoresistive, triboelectric, and thermodynamic technologies. This book also focuses on the different techniques, materials, comparisons of fabrication of self-powered sensors as well as thermoelectric self-powered sensors and its implantable applications.

Plant Function Traits: Linking Climate and Ecosystem Functioning, part of the Plant Biology, Sustainability and Climate Change series, presents a wholistic understanding of Plant Functional Traits. As global climate change advances, natural resources are facing increasing survival challenges, hence this book directly addresses that need, exploring the morphological, physiological, and phenological properties of a plant that can be used as a proxy to understand plant environment interactions. Users will find great illustrations throughout individual chapters, along with case studies that demonstrate applications of functional traits in classifying vegetation of a region into distinct type groups as Plant Functional Types (PFTs). Additional information includes applications in the development of new generation of Dynamic Global Vegetation Model (DGVM) and an understanding of the response of vegetation to changing environments.

Nonclinical Development of Biologics, Vaccines and Specialty Biologics, Second Edition, is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, vaccines, cell and gene therapies, and oncology therapeutics. Updated and revised, the new edition compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory guidelines. This book discusses the different types of biologics, as well as early characterization strategies, principles of study design, nonclinical pharmacokinetics and pharmacodynamics, nonclinical assays, and regulatory guidelines. A coedited book with chapters authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late-stage biologics.

Complex and Composite Metal Oxides for Gas, VOC, and Humidity Sensors, Volume 2: Technology and New Trends provides an overview of the advanced nanocomposite metal oxide materials used in sensors for environmental monitoring applications. Volume 2 discusses the state of the art in synthesis methods of innovative morphology, metal oxide hybrids, and heterostructures. It also describes the new generation of complex materials such as perovskites, spinel ferrites, and quaternary type-based gas and VOC sensors. This volume includes a brief discussion of advanced strategies for the development of futuristic sensors with properties such as room temperature operation, self-power generation, self-healability, flexibility, and wearability.

Handbook of MRI Pulse Sequences, Second Edition includes 92 self-contained sections, with each section focusing on a single subject. A new section on detailing the advanced pulse sequence techniques covers a variety of basic and advanced image reconstruction methods. The extensive topic coverage and cross-referencing makes this book ideal for beginners learning the building blocks of MRI pulse sequence design, as well as for experienced professionals who are seeking deeper knowledge of a particular technique. This book is among the most important medical imaging techniques available today. Each of these scanners is capable of running many different "pulse sequences." These sequences are governed by physics and engineering principles and implemented by software programs that control the MRI hardware.

Neuro-oncology broadly encompasses life-threatening brain and spinal cord malignancies, including primary lesions and lesions metastasizing to the central nervous system. It is well suited for diagnosis, classification, and prognosis as well as assessing treatment response. Radiomics and Radiogenomics (R-n-R) have become two central pillars in precision medicine for neuro-oncology. Radiomics is an approach to medical imaging used to extract many quantitative imaging features using different data characterization algorithms, while Radiogenomics, which has recently emerged as a novel mechanism in neuro-oncology research, focuses on the relationship of imaging phenotype and genetics of cancer. Due to the exponential progress of different computational algorithms, AI methods are composed to advance the precision of diagnostic and therapeutic approaches in neuro-oncology. The field of radiomics has been and definitely will remain at the lead of this emerging discipline due to its efficiency in the field of neuro-oncology. Several AI approaches applied to conventional and advanced medical imaging data from the perspective of radiomics are very efficient for tasks such as survival prediction, heterogeneity analysis of cancer, pseudo progression analysis, and infiltrating tumors. Radiogenomics advances our understanding and knowledge of cancer biology, letting noninvasive sampling of the molecular atmosphere with high spatial resolution along with a systems-level understanding of causal heterogeneous molecular and cellular processes. These AI-based R-n-R tools have the potential to stratify patients into more precise initial diagnostic and therapeutic pathways and permit better dynamic treatment monitoring in this period of personalized medicine. While extremely promising, the clinical acceptance of R-n-R methods and approaches will primarily hinge on their resilience to non-standardization across imaging protocols and their capability to show reproducibility across large multi-institutional cohorts. Radiomics and Radiogenomics in Neuro-Oncology: An Artificial Intelligence Paradigm ¿ Volume 2: Genetics and Clinical Applications provides readers with a broad and detailed framework for R-n-R approaches with AI in neuro-oncology, the description of cancer biology and genomics study of cancer, and the methods usually implemented for analyzing. Readers will also learn about the current solutions R-n-R can offer for personalized treatments of patients, limitations, and prospects. There is comprehensive coverage of information based on radiomics, radiogenomics, cancer biology, and medical image analysis viewpoints on neuro-oncology, so this in-depth coverage is divided into two Volumes. Volume 1: Radiogenomics Flow Using Artificial Intelligence provides coverage of genomics and molecular study of brain cancer, medical imaging modalities and analysis in neuro-oncology, and prognostic and predictive models using radiomics. Volume 2: Genetics and Clinical Applications provides coverage of imaging signatures for brain cancer molecular characteristics, clinical applications of R-n-R in neuro-oncology, and Machine Learning and Deep Learning AI approaches for R-n-R in neuro-oncology.

In this issue of Dermatologic Clinics, guest editor Dr. Hassan Galadari brings his considerable expertise to the topic of Hot Topics in Cosmetic Dermatology. Top experts cover key topics such as neurotoxin in the lower third of the face; chemical peels in the treatment of melasma; management of under eye darkness and wrinkles; facial overfilled syndrome; the needle vs. cannula debate in soft tissue augmentation; achieving the attractive Asian midface profile with hyaluronic acid-based fillers; and more.Contains 17 relevant, practice-oriented topics including updates on lasers in dermatology; update in assessment and treatment of botulinum toxin in the upper face; cosmetic dermatology in skin of color; management of cellulite; the effect of cosmetic procedures on the youth; and more.Provides in-depth clinical reviews on hot topics in cosmetic dermatology, offering actionable insights for clinical practice.Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Multi-Scale Precipitation Variability Over the Tropics: New Insights from Observations and Modelling explores the latest developments in the observation and modelling of tropical precipitation. Researchers will benefit from this detailed analysis of recent advancements in the field. The text first examines recent satellite and RADAR observations and how those breakthroughs enhance our understanding. This is followed by a review of NASA A-train observations as well as extreme events. The editors also look at predicting precipitation variability with a state-of-the-art ensemble forecast system. The text wraps with a discussion of multiscale cloud and precipitation variability with the backdrop of a changing climate. This text will provide researchers with new insights and a deeper understanding of the latest advances in the observation and modelling of tropical precipitation.

Adding Value to Fruit Wastes: Extraction, Properties, and Industrial Applications provides the latest technologies used in fruit waste to extract, isolate, and characterize functional, active compounds and their diversified pharmacological, food, agricultural, and industrial applications. Divided in three sections, the book explores emerging technologies for the extraction of functional components, discusses value-added components, and works as a guide to its applications. The book also covers fruit wastes for extracting starch to provide more cereal crops available as food, besides supporting the efficient utilization of fruit wastes to bring opportunities for extraction of functional components in a sustainable manner for food applications. Written by a team of experts in the field, this book provides technicians, researchers, food technology experts, food industry personnel, and academia with value addition to the fruit waste and a lot more opportunities for extraction of functional components in a sustainable manner for food applications.

Traditional Starch Food Products: Application and Processing is the fourth volume of the "Underground Starchy Crops of South American Origin" book series. Organized in five volumes, this series brings information on the applied level of producing and using starch from a range of plants grown in tropical and subtropical areas that have South American origin. This book describes the use of starchy roots, tubers and rhizomes in food, medicine, local culture, and religion, emphasizing the vital roles they play in indigenous Andean or Amazonian communities, offering cultural identity and economic value. The book’s comprehensive exploration highlights the multifaceted world of underground starchy crops, emphasizing the challenges to their successful development and preservation. Edited by a team of experts with solid background on starch extraction research, these books are aimed at all those involved in research and development, new technology processes and quality control and legislation in the field of starch.

Thoracic surgery has evolved substantially in recent years, with tremendous advancements in minimally invasive surgical procedures, novel techniques for sublobar resection,  perioperative management, and more. Thoracic Surgery Atlas, 2nd Edition, written by Dr. Mark K. Ferguson, brings you fully up to date with all aspects of this fast-changing field. Comprehensive and highly illustrated, this general thoracic surgery text covers procedures involving all chest organs (lungs, esophagus, trachea, mediastinum, chest wall, and diaphragm), offering authoritative guidance on virtually any thoracic operation you're likely to perform-from cancer surgery to management of a variety of benign conditions, including esophageal disorders, empyema, tracheal stricture, and much more. Includes authoritative, experience-based observations to help guide you through details of complex procedures, avoid common problems, and manage complications when they occur. Features numerous high-quality, original color and tone drawings that depict the relevant anatomy and steps associated with each procedure. Expands coverage to include new areas of thoracic surgery, new and updated illustrations, and new content and references throughout. Provides new information on ERAS protocol summaries for perioperative care, consensus guidelines for essential steps in minimally invasive lung resection, new surgical approaches to mediastinal abnormalities, increased focus on VATS and robotic operations including uniportal surgery, new methods of treating thoracic outlet syndrome, new approaches to managing malignant ventricular arrhythmias through sympathectomy, more advanced techniques for pleurectomy for mesothelioma, and descriptions of a variety of newer muscle flaps for reconstruction. An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Providing a solid foundation in the normal development of functional movement,Functional Movement Development Across the Life Span, 4th Editionhelps you recognize and understand typical functional movement in individuals from infancy to older adulthood, providing a framework from which to identify movement disorders and effectively manage patients with abnormal motor function. Divided into three units, this edition describes 1) theoretical frameworks of development, motor control/motor learning, and health/wellness; 2) anatomical and physiological development of the body systems comprising the movement system (muscular, skeletal, cardiopulmonary, nervous, sensory, integumentary, and endocrine); and 3) life span description of the movement functions of posture, balance, locomotion, prehension, and fitness. This edition integrates themes of the movement system, life span development, and health/wellness, providing you with the most current information needed for clinical decision making and to be an effective practitioner. Written by physical therapy experts Donna J. Cech, Suzanne "Tink" Martin, and William Staples, this book provides the evidence-based information and tools needed to understand functional movement and manage patients' functional skills throughout the life span. Dr. Staples brings his expertise in geriatric physical therapy and exercise in aging, enriching content on aging throughout the book.More than 200 illustrations, tables, and special featuresclarify developmental concepts, address clinical implications, and summarize key points relating to clinical practice.A logical, easy-to-read formatincludes 13 chapters organized into three units covering the definition of functional movement, movement system contribution to functional movement across the life span, and functional movement outcomes.A focus on evidence-based informationcovers development changes across the life span and how they impact function.NEW! The movement system framework is incorporated throughout, as well as a focus on health and wellness.NEW!Clinical Implicationboxeshelp you apply information into a clinical framework.Revised contentthroughout provides you with the most current information needed to be an effective practitioner.Updated referencesensure content is current and applicable for today¿s practice.NEW!An ebook version isincluded with print purchase.The ebook allows you to access all the text, figures, and references, with the ability to search, customize your content, make notes, and highlights, and have content read aloud.

Visualizing More Quaternions is a sequel to Dr. Andrew J. Hanson’s first book, Visualizing Quaternions, which appeared in 2006. This new volume develops and extends concepts that have attracted the author’s attention in the intervening 18 years, providing new insights into existing scholarship, and detailing results from Dr. Hanson’s own published and unpublished investigations relating to quaternion applications. Among the topics covered are the introduction of new approaches to depicting quaternions and their properties, applications of quaternion methods to cloud matching, including both orthographic and perspective projection problems, and orientation feature analysis for proteomics and bioinformatics. The quaternion adjugate variables are introduced to embody the nontrivial quaternion topology on the three-sphere and incorporate it into machine learning tasks. Other subjects include quaternion applications to a wide variety of problems in physics, including quantum computing, complexified quaternions in special relativity, and a detailed study of the Kleinian "ADE"discrete groups of the ordinary two-sphere. Quaternion geometry is also incorporated into the isometric embedding of the Eguchi-Hanson gravitational instanton corresponding to the k = 1 Kleinian cyclic group. Visualizing More Quaternions endeavors to explore novel ways of thinking about challenging problems that are relevant to a broad audience involved in a wide variety of scientific disciplines.

For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the 10th edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes.Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.Includes significant new content throughout: a new chapter on the endocrine system and hormones; newly distinct chapters on the heart and lung; new content on social disparities in lupus, clinical presentation of nephritis, and pulmonary hypertension; a new concluding chapter on future directions in the field; new basic science coverage of the microbiome, autoinflammatory, and monogenic lupus; and new coverage of diversity, inclusion, gender, compliance, and adherence.Offers a fresh perspective from two new associate editors and many new authors with representation from 30 countries.Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients.Discusses the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS).Presents the knowledge and expertise of international contributors to provide new global perspectives on manifestations, diagnosis, and treatment.Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, new and improved figures, and schematic diagrams throughout.An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.

Covering everything from preoperative evaluation to neonatal emergencies to the PACU, Coté, Lerman and Anderson’s A Practice of Anesthesia in Infants and Children, 7th Edition, features state-of-the-art advice on the safe, effective administration of general and regional anesthesia and sedation strategies for young patients. This text reviews underlying scientific information, addresses preoperative assessment and anesthesia management in detail, and provides guidelines for postoperative care, emergencies, and special procedures. Comprehensive in scope and thoroughly up to date, this edition delivers unsurpassed coverage of every key aspect of pediatric anesthesia.Presents must-know information on standards, techniques, and the latest advances in pediatric anesthesia from global experts in the field.Contains thoroughly updated content throughout, with new contributors to lend a fresh perspective, updated figures and tables, and the latest information on perioperative fluid management, pharmacology, interventional devices, resuscitation, and more.Covers key topics such as anesthetizing children with cancer, neonatal and pediatric emergencies, the obese child and bariatric surgery, interventional devices for children with congenital heart defects, cardiopulmonary resuscitation, simulation in pediatric anesthesia, patient safety and quality assurance, and more.Features an extensive video library of pediatric anesthesia procedures, particularly difficult airway management strategies, new positioning devices, cardiac assist devices in action, management of burn injuries, how to perform ultrasound-guided regional anesthesia blocks and techniques, and much more.Essentials chapters provide focused input from expert subspecialty pediatricians who share the latest information concerning hematology, pulmonology, oncology, hepatology, nephrology, and neurology.Includes a laminated pocket reference guide with essential, practical information, and key references at the end of each chapter that provide a quick summary for review.An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.

Marine Bivalve Mollusks and Emerging Pollutants: Toxicological Impacts provides the most updated and comprehensive knowledge of the toxicological impacts of a variety of emerging pollutants on marine bivalve mollusk species. In addition to synthesizing recent toxicological findings, the book also discusses toxification mechanisms, current challenges, and future research prospects. Written by international experts, this book assesses new advances in the toxicological impacts of pollutants, including microplastics, bromide flame retardants, nanomaterials, pharmaceutical residues, personal care products, pesticides, and perfluorinated compounds. In addition, it details how these can affect reproduction, embryonic development, metabolism, and immune systems of marine bivalves. Behavioral responses and neuroendocrine regulation is also discussed. Toxification mechanisms are interpreted at both physiological and molecular levels. The book concludes with current research and environmental challenges and potentials for further, future study techniques.

In Neuroscience Without Representations, an Open Access book, Oscar Vilarroya addresses the notion of "representation" as used in expressions like "neural representation" or "mental representation". This concept is fundamental in neuroscience, yet there remains no clear, universally accepted view on what it means for a nervous system to represent something, what constitutes a neural activity as a representation, and what is being re-presented. The book lays the foundation for a non-representational view of brain function. Building upon György Buzsáki’s critique of the theoretical framework underlying current cognitive neuroscience, Vilarroya argues that disciplines such as embodied and embedded cognition-collectively known as ‘4E cognition’-are driving a paradigm shift in our understanding of animal cognition. Rather than grounding cognition solely in representations, the author proposes an alternative: understanding cognition as enaction-the meaningful engagement of an organism to address situational requirements. The book supports this approach through detailed analyses of recent studies.

Microbial Genomics: Clinical, Pharmaceutical and Industrial Applications focuses on the various applications of microbial genomics in clinical, pharmaceutical, and industrial fields. The book consists of four parts devoted to bacterial, viral, and fungal genomics, as well as their applications in clinical, pharmaceutical, and industrial fields. Chapters are written by experts in their respective disciplines and are tightly organized with an introduction to detailed descriptions, available software implementation, applications, advanced topics, summaries, analytic questions, exercises, and suggested readings. Throughout this book, the latest genomics and biotechnological developments and discoveries as well as open problems and future challenges on microbial genomics are highlighted. Readers will be introduced to state-of-the-art developments and trends of microbial genomics, its clinical, pharmaceutical, and industrial applications.

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.