Bøger udgivet af Kluwer Academic Publishers

The chapters in this book were compiled by a trio of experts in the field of eye movements and contain discussions of anatomy and physiology of the ocular motor system, techniques of examination of patients with diplopia, and pathophysiology of specific disorders of ocular motility.

xi List of first authors xiii Acknowledgements xv INTRODUCTICN Approaches to radiolabelling blood d-c cells: past, present and future M. L. Thakur 3 CELL LABELLllJG TEDlNIQUES 2 Labelling techniques of granulocytes and platelets 17 with 111 In-oxinate M. R. Hardeman, E. G. J. Eitjes-van Overbeek, A. J. M. van Velzen, M. H. Rovekarnp 111rndium-labelling of human washed platelets; kinetics 3 29 and in vivo sequestration sites M. Eber, J. P. Cazenave, J. C. Grob, J. Abecassis, G. !o1ethlin 111Indium loss from platelets by in vitro and ex 4 44 vivo manipulation R. J. Hawker, C. E. Hall, H. C-oldman, C. N. McCollum PIATELEl'S: KrnETIC STUDIES 5 The maturation of megakaryocytes and their precursors 65 J. H. Paulus 6 !o1egakaryocytic precursors 74 J. Breton-Gorius, W. Vainchenker 7 !-1ethods of quantification of platelet production 86 in man. A critical analysis Y. Najean vi 8 Platelet production rate deteDmination with (75se)_ seleno-m:thionine R. Cardinaud, E. Dassin 96 9 Platelet kinetics: the state of the art A. duP Heyns 110 10 Platelet kinetics A. M. Peters 130 Evaluation of models to deteDmine platelet life 11 span and survival curve shape M. G. LOtter, C. P. Herbst, P. N. Badenhorst, A. duP Heyns, P. Wessels, P. C. Minnaar 139 12 Canparison of three m:thods evaluating platelet survival tim: in patients with prosthetic heart valve J. Schbath, D. Ville, B. Hathy, B. Sanchini, E. Benveniste, J. Belleville, M. Dechavanne, J. P. Boissel, J.

Proceedings of a Workshop Held in Pisa, April 11-12, 1983. Sponsored by the Commission of the European Communities, as advised by the Committee on Medical and Public Health Research

Just prior to the 1982 Annual Meeting of the European Thyroid Association in Brussels, a number of outstanding experts in the field of X-ray fluorescence gathered at the Academisch Ziekenhuis of the Free University of Brussels in a joint effort to more clearly define the actual place and value of the latest newcomer among the techniques available for the in vivo assessment of thyroid function. It is the merit of Prof. M. Jonckheer to have organised this meeting and to have made available the work presented there to a larger public in the form of this monograph. Both, the meeting and the written accounts thereof are greatly appreciated by all thyroidologists who care for properly defining the genuine value of X-Ray fluorescence in scientific research and in clinical management of thyroid disorder. Three main conclusions can be drawn from the work presented 1. X-ray fluorescence has become a safe, convenient and reliable tool for measuring intrathyroidal iodine stores in vivo with an inter-assay reproducibility estimated at roughly 10% 2. X-ray fluorescence, used by expert hands, is a highly interesting tool to follow changes of intra thyroidal iodine stores in time, subsequent e. g. to the exposure of the thyroid gland to excess iodine 3. In contrast, no definite place of X-ray fluorescence as a technique in routine assessment of thyroid disease is yet at the horizon This latter conclusion may appear somewhat disappointing.

a specialist quarterly, the Journal of Economic Psychology, commenced publication in 1981, with 1985 seeing the first issue of the Journal of Interdisciplinary Economics as yet another addition to growing ranks of "psychology-friendly" journals such as the Journal of Consumer Research and the Journal of Social Economics;

New Zealand.- Oman.- Pakistan.- Papua New Guinea.- Philippines.- Samoa.- Saudi Arabia.- Singapore.- Solomon Islands.- Syria.- Taiwan.- Thailand.- Tonga.- Turkey.- Tuvalu.- United Arab Emirates.- Vanuatu.- Socialist Republic of Vietnam.- Yemen Arab Republic.- Yemen People¿s Democratic Republic.

The enormous advances in diagnostic imaging techniques and in interven- tional, radiological and biliary approaches, the pathophysiological problems and their management manifest often as complications in the post-operative period, new techniques and the results of surgical approaches are all thorough- ly documented.

These commentaries are based almost entirely on the formal and informal documentation of the Third United Nations Conference on the Law of the Sea (UNCLOS III, 1973-1982), coupled, where necessary, with the personal knowledge of editors, contributors, or reviewers, many of whom were principal negotiators or UN personnel who participated in the Conference.

This book is a unique work devoted to the subject of disordered defaecation. It contains chapters written by experts in the field of ano-rectal physiology and management of disordered defaecation. The various contributions present personal views and special clinical experience of individuals. There are some personal views which we felt should be commented upon and a few areas where the experience of others has been included into the text. For the sake of completeness of each chapter, a slight overlap in some cases was inevitable. We hope the book will serve as a useful collection of opinions on a subject which until recently has been largely ignored by the medical profession. The editors Major contributors H. O. ten Cate Hoedemaker Department of Surgery, University Hospital, Rijnsburgerweg 10,2333 AA Leiden, The Netherlands G. Coremans Department ofInternal Medicine, University Hospital Gasthuisberg, Here­ straat 49, 3000 Leuven, Belgium S. Fasth Department of Surgery II, Sahlgrenska Hospital, S-413 45 G6teborg, Swe­ den H. G. Gooszen Department of Surgery, University Hospital, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands J. A. Gruwez Department of General Surgery, University Hospitals KU, Brusselsestraat 63,3000 Leuven, Belgium M. M. Henry Department of Gastroenterology, Central Middlesex Hospital, Acton Lane, London NWlO 7NS, United Kingdom M. R. B. Keighley Department of Surgery, The General Hospital, Steelhouse Lane, Bir­ mingham B4 6NH, United Kingdom J. H. C. Kuypers Department of Surgery, University Hospital St. Radboud, Geert Groote­ plein Zuid 14,6500 HB Nijmegen, The Netherlands Ph. B.

Proceedings of the Third International Symposium on Body Surface Mapping

A Seminar in the CEC Agricultural Research Programme, held in Dublin, Ireland, November 21-22, 1985. Sponsored by the Commission of the European Communities, Directorate-General for Agriculture, Division for the Coordination of Agricultural Research

However, around 1980 pessimists predicted the premature demise of cardiovascular nuclear imaging with the introduction of digital subtraction angiography and nuclear magnetic resonance imaging.

In recent years there has been an increasing interest in quantitative analysis of coronary cineangiograms and already for a longer time of left ventricular cin­ eangiograms. The needfor quantitationofcoronary arterialdimensions has been stimulated by the introduction ofnew therapeutic procedures in the catheteriza­ tionlaboratory, suchas the balloon dilatationtechnique (PTCA) and thromboly­ tic therapy, by the need to study the vasoactive responses of pharmaceutical agents, and also by the desire to study the progressive nature ofcoronary artery disease with the ultimate goal to find ways to bring a halt to the progression of coronary atherosclerosis or even achieve regression of the disease. Parallel with these clinical developments, rapid technical developments in computerarchitect­ ures and semiconductor memories have made it possible to digitize and store cineframesor selected portions thereof in image processors and to analyze these pictorial data quantitatively at affordable prices. More than 15 years of research have been directed by various groups towards the semi- or fully-automated delineation of the left ventricular boundaries on a frame-to-frame basis. Yet not a single system with fully-automated capability is commercially available. In the mean time many different left ventricular wall motion models have been developed, again with little consensuson which model is to be preferred as no golden standard exists.

Cardiac Cardiac imaging imaginghas has rapidly rapidlyevolved evolved into intoa a specialized specialized area area of of interest interestshared shared by by cardiolo­ cardiolo­ gists, radiologists, engineers, physicists, and statisticians. Our book, Digital gists,radiologists,engineers,physicists,andstatisticians.

As prices stayed at low levels, while those of other materials recovered over the 1983-1986 period, the question became that of why metals prices had remained at startlingly low levels for over five years.

Ingrained for many years in the science of educational assessment were a large number of "truths" about how to make sense out of testing results, artful wisdoms that appear to have held away largely by force of habit alone.

PREFACE xv Il Y a une ou deux decennies les ingenieurs ont crn ou voulu faire croire que l'automatisation des systemes de production et de contrOle permettrait de s'affranchir entierement de ce maillon faillible que constitue l'Homme.On a meme vu une reunion scientifique se reunir sur Ie theme "L'homme element limitatif de l'utilisation des systemes d'armes". Dne telle attitude montre avant tout que 1'0n n'a pas su integrer l'utilisateur dans la conception du systeme considere. Elle consacre la faillite d'un concept. On est revenu a une notion plus realiste de la situation. En effet, meme dans les systemes dits "entierement automatises" on trouve toujours un ou plusieurs hommes, indispensables pour surveiller Ie deroulement du processus, intervenir lorsque se produit une defaillance, voire reprendre en main l'ensemble des operations lorsque survient un incident. Le developpement des automatismes modifie evidemment la tache de 1'0perateur. L'homme contribue moins directement a la production elle-meme, en ce sens qu'on n'exige plus de lui un effort physique. On lui confie, dans des conditions de travail encore inhabituelles et auxquelles il n'est pas specialement prepare, des systemes dont les couts sont tres eleves et qui risquent d'etre deteriores s'il commet la moindre faute. Sans compter les risques qu'il est alors susceptible de faire courir a ses concitoyens. Le bon sens reprenant le dessus, on s'interesse maintenant a la place de l'Homme confronte a ces situations qu'il rencontre de plus en plus frequemment dans l'industrie.

In the last 15 years we have had the opportunity to teach Electrocardiography to many different types of student: doctors preparing to become cardiologists, cardiologists attending weekly 'refresher' sessions at our hospital, general practitioners who wish to become adept at electrocardiography and attend our yearly courses and, finally, the medical students of the Universidad Aut6noma of Barcelona. We cover everything with these students from the basics of electrophysiology to applied electrocardiographic semiology. This quadruple experience has proved stimulating, constantly motivating the search for better and more precise material, and the most appropriate didactic presentation for each type of student, each of whom has different requirements. I have always felt that didactic capability is not related to the intelligence of the professor, or to the amount of knowledge this person possesses, but really depends on the 'quality' of this knowledge, the 'desire' to transmit it and the 'capacity' to adapt to each teaching situation.

The author insists neither the ambiguity of the European system for the Protection of Human Rights, nor the resistance of States to the system of the European must be overlooked. He asks "Has a Europe of Human Rights" begun to develop through the complex interplay of national and European norms?

The introduction to this English translation of a selection from Van Vollenhoven's study of indigenous Indonesian law outlines the historical significance of his work, showing its background in the complex administrative and legal system of the Dutch East Indies, the trends in Dutch colonial legal and economic policy, and the development of adat law scholarship from the early 1900s onwards. The chapters chosen concentrate almost entirely on the adat law of some of the indigenous peoples of Indonesia.

Complex systems problems can challenge and tax our logical capability to fully understand their causes and the consequences of any action we may take to solve them.

J.J. Broerse, Radiobiological Institute TNO, Rijswijk, The Netherlands, and T .J. MacVittie, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA. During the past decade, relatively few new studies have been initiated on the response of different species to high-dose, total-body irradia­ tion. For information on the LDSO/30d (the dose which produces 50 percent lethality within 30 days), one is generally referred to the older literature (e. g., Bond, Fliedner and Archambeau, 1965). Compari­ son of experimental data reveals considerable variations in LDSD values even after total-body irradiation with conventional X rays, ranging from 4 to 6 Gy in the monkey, 7.1 to 9 Gy in the rat and from 6.4 to 9 Gy in the mouse (see also Hall, 1978). Part of the discrepancy in the LDso values can possibly be attributed to inadequacies in the dosimetry procedures and exposure arrangements employed. As far as clinical experience is concerned, there is now an appreciable amount of information available about the effect of total­ body irradiation as a conditioning treatment for bone marrow transplan­ tation in patients suffering from leukaemia or aplastic anaemia. The results from different centres, including the incidence of complications such as radiation pneumonitis, are considerably different. This can part I y be connected with the application of different radiation sched­ ules: large single dose versus fractionated or protracted irradiation.

Govier and Reves discuss in some detail the general effects of anesthetic agents upon brain metabolic needs as well as their important data demonstrating preserva tion of brain blood flow autoregulation during cardiopulmonary bypass (CPB) as practiced at the University of Alabama.

Proceedings of the Fourth Conference on Mononuclear Phagocytes, Held in Leiden, The Netherlands, May 9-16, 1984

Proceedings of the Second International Symposium on Biology of Brain Tumour, London, October 24-26, 1984