Bøger udgivet af National Academies Press

Offers research about the mind and the brain that provides answers to a number of compelling questions. This book uses exemplary teaching to illustrate how approaches based on what we now know result in in-depth learning. The knowledge calls into question concepts and practices firmly entrenched in our education system.

Concerted efforts to deepen understanding of RNA modifications and their role in living systems holds the potential to advance human health, improve crop yields, and address other pressing societal challenges. RNA, which carries the information encoded by DNA to the places where it is needed, is amazingly diverse and dynamic. RNA is processed and modified through natural biological pathways, giving rise to hundreds, in some cases thousands, of distinct RNA molecules for each gene, thereby diversifying genetic information. RNA modifications are known to be pivotal players in nearly all biological processes, and their dysregulation has been implicated in a wide range of human diseases and disorders. Yet, our knowledge of RNA modifications remains incomplete, hindered by current technological limitations. Existing methods cannot discover all RNA modifications, let alone comprehensively sequence them on every RNA molecule. Nonetheless, what is known about RNA modifications has already been leveraged in the development of vaccines that helped saved millions of lives worldwide during the COVID-19 pandemic. RNA modifications also have applications beyond health, for example, enhancing agricultural productivity. Charting a Future for Sequencing RNA and Its Modifications: A New Era for Biology and Medicine calls for a focused, large-scale effort to accelerate technological innovation to harness the full potential of RNA modifications to address pressing societal challenges in health, agriculture, and beyond. This report assesses the scientific and technological breakthroughs, workforce, and infrastructure needs to sequence RNA and its modifications, and ultimately understand the roles RNA modifications play in biological processes and disease. It proposes a roadmap of innovation that will make it possible for any RNA from any biological system to be sequenced end-to-end with all of its modifications - a capability that could lead to more personalized and targeted treatments and instigate transformative changes across various sectors beyond health and medicine.

"This study was supported by Contract/Grant No. W911NF-13-D-0002-0001 between the National Academy of Sciences and the U.S. Army."--Title page verso.

"Scientific research has enabled America to remain at the forefront of global competition for commercially viable technologies and other innovations. For more than 65 years, the United States has led the world in science and technology. Discoveries from scientific research have extended our understanding of the physical and natural world, the cosmos, society, and of humans - their minds, bodies, and economic and other social interactions. Through these discoveries, science has enabled longer and healthier lives, provided for a better-educated citizenry, enhanced the national economy, and strengthened America's position in the global economy. At a time of budget stringency, how can we foster scientific innovation to ensure America's unprecedented prosperity, security, and quality of life? Although many studies have investigated the impacts of research on society, Furthering America's Research Enterprise brings to bear a fresh approach informed by a more holistic understanding of the research enterprise as a complex, dynamic system. This understanding illuminates why America's research enterprise has historically been so successful; where attention should be focused to increase the societal benefits of research investments; and how those who make decisions on the allocation of funds for scientific research can best carry out their task. This report will be of special interest to policy makers who support or manage the research enterprise, to others in public and private institutions who fund research, to scholars of the research enterprise, and to scientists and engineers who seek to better understand the many pathways through which their research benefits society."--Publisher's description.

This overview includes chapters on child mortality, adult mortality, fertility, proximate determinants, marriage, internal migration, international migration, and the demographic impact of AIDS.

Spatial statistics is one of the most rapidly growing areas of statistics, rife with fascinating research opportunities. Yet many statisticians are unaware of those opportunities, and most students in the United States are never exposed to any course work in spatial statistics. Written to be accessible to the nonspecialist, this volume surveys the applications of spatial statistics to a wide range of areas, including image analysis, geosciences, physical chemistry, and ecology. The book describes the contributions of the mathematical sciences, summarizes the current state of knowledge, and identifies directions for research.

As more people live longer, the need for quality long-term care for the elderly will increase dramatically. This volume examines the current system of nursing home regulations, and proposes an overhaul to better provide for those confined to such facilities. It determines the need for regulations, and concludes that the present regulatory system is inadequate, stating that what is needed is not more regulation, but better regulation. This long-anticipated study provides a wealth of useful background information, in-depth study, and discussion for nursing home administrators, students, and teachers in the health care field; professionals involved in caring for the elderly; and geriatric specialists.

The information age is taking its toll on traditional office management techniques. According to Infosystems, "If you're cautious of 'experts' who claim to have all the answers, then you'll find comfort in the theme of 'unleashed creativity' that recurs throughout the 20 essays presented in this book....Organizations will have to devise a strategy for understanding how [a microcomputer's] performance can be monitored. Regardless of what may happen, this book provides managers with appropriate ammunition."

This volume documents the continuing growth of concentrated poverty in central cities of the United States and examines what is known about its causes and effects. With careful analyses of policy implications and alternative solutions to the problem, it presents: A statistical picture of people who live in areas of concentrated poverty. An analysis of 80 persistently poor inner-city neighborhoods over a 10-year period. Study results on the effects of growing up in a "bad" neighborhood. An evaluation of how the suburbanization of jobs has affected opportunities for inner-city blacks. A detailed examination of federal policies and programs on poverty. Inner-City Poverty in the United States will be a valuable tool for policymakers, program administrators, researchers studying urban poverty issues, faculty, and students.

In developing countries, traditional fishermen are important food contributors, yet technological information and development assistance to third-world nations often focuses on agriculture and industrial fishing, without addressing the needs of independent, small-scale fishermen. This book explores technological considerations of small-scale, primitive fishing technologies, and describes innovative, relatively inexpensive methods and tools that have already been successfully applied in developing countries. It offers practical information about all aspects of small-scale fishing, including boat design and construction, fishing methods and gear, artificial reef construction and fish aggregating devices, techniques for coastal mariculture, and simple methods for processing and preserving fish once they are caught. Fisheries Technologies for Developing Countries is illustrated throughout with photographs of the devices and construction methods described in the text.

This book presents a carefully developed monitoring system to track the progress of mathematics and science education, particularly the effects of ongoing efforts to improve students' scientific knowledge and mathematics competency. It describes an improved series of indicators to assess student learning, curriculum quality, teaching effectiveness, student behavior, and financial and leadership support for mathematics and science education. Of special interest is a critical review of current testing methods and their use in probing higher-order skills and evaluating educational quality.

In this provocative volume, distinguished authorities on urban policy expose the myths surrounding today's "infrastructure crisis" in urban public works. Five in-depth papers examine the evolution of the public works system, the limitations of urban needs studies, the financing of public works projects, the impact of politics, and how technology is affecting the types of infrastructures needed for tomorrow's cities.

The border region shared by the United States and Mexico is currently experiencing multiple crises on both sides that present challenges to safeguarding the region's sustainable natural resources and to ensuring the livelihoods of its residents. These challenges are exacerbated by stressors including global climate change, increasing urbanization and industrialization and attendant air and water-quality degradation, and rapid population growth. Navigating these challenges and preserving the area's cultural richness, economy, and ecology will require building strategic partnerships that engage a broad range of stakeholders from both countries. To navigate these challenges, the U.S. National Academies of Sciences, Engineering, and Medicine, together with the Mexican Academy of Sciences (Academia Mexicana de Ciencias), Mexican Academy of Engineering (Academia de Ingenier?a de M?xico), and Mexican National Academy of Medicine (Academia Nacional de Medicina de M?xico), appointed a committee of experts from the United States and Mexico to conduct a consensus study. Advancing United States-Mexico Binational Sustainability Partnerships incorporates features of the United Nations 2030 Agenda for Sustainable Development, in particular, Sustainable Development Goal (SDG) 17. SDG 17 calls for revitalizing global partnerships for sustainable development. It is specifically focused on the advancement of multi-stakeholder partnerships that require coordination and collaboration among diverse stakeholders in pursuit of a common and mutually beneficial vision. With attention to SDG 17, this report draws on social science theory and applied research on partnerships to explore potential strategies and mechanisms to increase coordination between relevant government agencies, the private sector, and civil society in the United States and Mexico.

Influenza viruses, both seasonal and pandemic, have the potential to disrupt the health and well-being of populations around the world. The global response to the COVID-19 pandemic and prior public health emergencies of international concern illustrate the importance of global preparedness and coordination among governments, academia, scientists, policy makers, nongovernmental organizations, the private sector, and the public to address the threat of pandemic influenza. These health emergencies have revealed opportunities to enhance global vaccine infrastructure, manufacturing, distribution, and administration. Globally Resilient Supply Chains for Seasonal and Pandemic Influenza Vaccines outlines key findings and recommendations to bolster vaccine distribution, manufacturing, and supply chains for future seasonal and pandemic influenza events. This report addresses the challenges of manufacturing and distributing vaccines for both seasonal and pandemic influenza, highlighting the critical components of vaccine manufacturing and distribution and offering recommendations that would address gaps in the current global vaccine infrastructure.

Facial recognition technology is increasingly used for identity verification and identification, from aiding law enforcement investigations to identifying potential security threats at large venues. However, advances in this technology have outpaced laws and regulations, raising significant concerns related to equity, privacy, and civil liberties. This report explores the current capabilities, future possibilities, and necessary governance for facial recognition technology. Facial Recognition Technology discusses legal, societal, and ethical implications of the technology, and recommends ways that federal agencies and others developing and deploying the technology can mitigate potential harms and enact more comprehensive safeguards.

When waterfowl began to die from selenium poisoning at Kesterson National Wildlife Refuge in California's San Joaquin Valley, considerable alarm arose among environmental and agricultural specialists. This new volume suggests that Kesterson is not a unique problem and the events there offer important lessons for the future. Irrigation-Induced Water Quality Problems uses the San Joaquin experience to suggest how we can prepare for similar problems elsewhere. As one committee member put it, "There will be elsewheres"?trace elements and organic contaminants are being concentrated by irrigation in many river basins. This book addresses how the Kesterson crisis developed, how irrigation can endanger water quality, and how economic, legal, and other factors impede our ability to respond to water quality problems. The committee explores how to study these problems, unraveling complex issues and clarifying the varying perspectives of farmers, environmentalists, scientists, and other key figures. This dispassionate analysis of a controversial topic will be useful to policymakers, resource managers, and agricultural specialists and farmers, as well as specialists in hydrology, water quality, irrigation, law, and environmental quality. It will also be useful as a case study in the environmental policy classroom.