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The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes-and indeed because of them-our ability to deliver new medicines may be quickly coming to an end. Moving from the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy.To explain how we have arrived at this pivotal moment, Michael S. Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century, relating stories of the individuals and organizations that ushered in the modern era of translational medicine. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing the very infrastructure that had fostered the introduction of innovative new medicines. As Kinch demonstrates, the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come.
A timely and important book that explores the societal and ethical implications of artificial intelligence as we approach the cusp of a fourth industrial revolutionGeorge Zarkadakis explores one of humankind's oldest love-hate relationships: our ties with artificial intelligence, or AI. He traces AI's origins in ancient myth, through literary classics like Frankenstein to today's science fiction blockbusters, arguing that a fascination with AI is hardwired into the human psyche. He explains AI's history, technology, and potential; its manifestations in intelligent machines; its connections to neurology and consciousness, as well as-perhaps most tellingly-what AI reveals about us as human beings.In Our Own Image argues that we are on the brink of a fourth industrial revolution-poised to enter the age of artificial intelligence as science fiction becomes science fact. Ultimately, Zarkadakis observes, the fate of AI has profound implications for the future of science and humanity itself.
Presented in a CD format, this work provides information on developing and measuring true Overall Equipment Effectiveness (OEE). It demonstrates that true OEE correlates with factory output, provides a methodology to link OEE with net profits that can be used by reliability managers to build solid business cases for improvement projects, and more.
In the course of our enduring quest for knowledge about ourselves and our universe, we haven't found answers to one of our most fundamental questions: Does life exist anywhere else in the universe? Ten years and billions of dollars in the making, the Mars rover Curiosity is poised to answer this all-important question.Here, Rob Manning, the project's chief engineer, tells of bringing the groundbreaking spacecraft to life. Manning and his team at NASA's Jet Propulsion Laboratory, tasked with designing a lander many times larger and more complex than any before, faced technical setbacks, fights over inadequate resources, and the challenges of leading an army of brilliant, passionate, and often frustrated experts.Manning's fascinating personal account-which includes information from his exclusive interviews with leading Curiosity scientists-is packed with tales of revolutionary feats of science, technology, and engineering. Listeners experience firsthand the disappointment at encountering persistent technical problems, the agony of near defeat, the sense of victory at finding innovative solutions to these problems, the sheer terror of staking careers and reputations on a lander that couldn't be tested on Earth, and the rush of triumph at its successful touchdown on Mars on August 5, 2012. This is the story of persistence, dedication, and unrelenting curiosity.
In his second in-depth foray into the world of professional cooking, Michael Ruhlman journeys into the heart of the profession. Observing the rigorous Certified Master Chef exam at the Culinary Institute of America, the most influential cooking school in the country, Ruhlman enters the lives and kitchens of rising star Michael Symon and the renowned Thomas Keller of the French Laundry. This fascinating book will satisfy any reader's hunger for knowledge about cooking and food, the secrets of successful chefs, at what point cooking becomes an art form, and more.Like Ruhlman's The Making of a Chef, this is an instant classic in food writing-one of the fastest growing and most popular subjects today.
Highlighting materials research and innovations for a variety of energy systems and technologies, the sections include: Energy and Environmental Issues in Materials; Manufacturing and Processing Materials in Clean Power; Materials for Coal-Based Power; Energy Conversion with Emphasis on SOFC; Gas Turbines; Nuclear Energy; and Oil and Gas.
Findings from The Eighth International Conference on Permafrost with 230 contributions showing the rich diversity of research being conducted. Includes all major scientific, technical and engineering aspects of frozen ground, and planetary processes.
Presents an interactive program for the calculation of thermophysical properties of more than 60 fluid substances (gases and liquids). This software package allows you to calculate up to 35 diagram types for different properties, including the well known h-s, T-s, p-h and p-rho diagrams.
This CD-ROM is an interactive and detailed introduction to the physics and technology of the generation of coherent radiation from accelerators as well as to its widespread high-tech applications in science, medicine and engineering.
Including a textbook, numerous interactive examples, this title is intended to be used by lecturers and teaching personnel.
Macintosh/Windows Version 1.0 With contributions by numerous experts
Macintosh / Windows Version
Macintosh / Windows Version
With data that can be viewed on screen and printed in a predefined format, this title includes information on additive name and its chemical structure (if it is a single compound disclosed by the manufacturer). It features five sections: General Information, Physical Properties, Health and Safety, Ecological Properties, and Use & Performance.
Exclusively from McGraw-Hill Professional and InfoComm International, this exam guide covers the latest Certified Technical Specialist Design exam for AV professionals.
A comprehensive manual that examines the systems available for data capture and photogrammetic processing. Included within the 12 chapters are the principles of digital systems, digital aerial photography, cameras, survey-camera mountings, survey navigation, GPS and (d)GPS systems.
A comprehensive guide to nonmetallics, featuring easy click-and-go navigation; fast searching and easy access; and searchable high-resolution figures. Ths CR-Rom contains complete text and figures.
This CD-ROM contains the electronic version of the FAO Species Identification Sheets for Fishery Purposes for the Eastern Central Atlantic (Fishing Areas 34 and part of 47) published in 7 volumes in 1981. The Identification Sheets are aimed at establishing an annotated illustrated inventory of aquatic species of interest to fisheries.
Sets forth the conditions under which permitted food additives may be used in all foods. This database provides, in a searchable format, all the provisions for food additives that have been adopted by the Codex Alimentarius Commission. Provisions are searchable by food additive (name, synonym, INS number), by functional class and by food category.
The Codex Alimentarius (food code) is the single, most important global reference point for consumers, food producers and processors, national food control agencies and the international food trade. This CD-ROM contains over 400 international standards, guidelines and codes of practice, recognised as benchmarks by the World Trade Organisation.
This text seeks to broaden and improve aquifer test analysis by generating type curves for complicated aquifer and well conditions. It simplifies type curve matching with on-screen interactive techniques, and introduces a statistical semi-automatic protocol for calibrating aquifer test site models.
Offers a PC-based program designed for regulatory screening and prioritizing and industrial screening of chemicals. This work intends to take the guesswork out of calculating the probability of a chemical biodegrading rapidly or slowly under anaerobic conditions in a mixed culture of microorganisms.
Presents a database that contains regulatory information for over 500 chemicals. This title offers regulatory information affecting hazardous chemicals. It is suitable for chemical manufacturers, environmental engineers, environmental chemists, industrial hygienists, toxicologists, lawyers, and federal and state regulators.
This reference work on pesticides comes on a 3.5" computer disk, and provides details of 386 of the most commonly used pesticide chemicals registered by the EPA. It can be used to locate additional data and references for a known compound, or to identify an unknown compound.
Contains information on 137 pesticides. This work profiles each pesticide and provides regulatory information; toxicity assessments; environmental fate data; physical properties; and, acceptable exposure limit values. It features environmental and physical/chemical data on more than 300 compounds, including pesticides, herbicides and fungicides.