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A NATO Advanced Research Workshop on Strongly Coupled Plasma Physics was held on the Santa Cruz Campus of the University of California, from August 4 through August 9, 1986. It was attended by 80 participants from 13 countries, 45 of whom were invited speakers. The present volume contains the texts of the invited talks and many of the contributed papers. The relative length of each text is roughly proportional to the length of the workshop presentation. The aim of the workshop was to bring together leading researchers from a number of related disciplines in which strong Coulomb interactions play a dominant role. Compared to the 1977 meeting in Orleans-la-Source, France and the 1982 meeting in Les-Houches, France, it is apparent that the field of strongly coupled plasmas has expanded greatly and has become a very significant field of physics with a wide range of applications. This workshop had a far greater participation of experimental researchers than did the previous two, and some confrontations of real experiments with theoretical calculations occurred. In the two earlier meetings the theoretical presentations were dominated by numerical simulations of static and dynamic properties of various strongly coupled plasmas. The dearth of experiments in the 1970's is now replaced by some very good experimental efforts.

Phonons are always present in the solid state even at an absolute temperature of 0 K where zero point vibrations still abound. Moreover, phonons interact with all other excitations of the solid state and, thereby, influence most of its properties. Historically experimental information on phonon transport came from measurements of thermal conductivity. Over the past two decades much more, and much more detailed, information on phonon transport and on many of the inherent phonon interaction processes have come to light from experiments which use nonequilibrium phonons to study their dynamics. The resultant research field has most recently blossomed with the development of ever more sophisticated experimental and theoretical methods which can be applied to it. In fact, the field is moving so rapidly that new members of the research community have difficulties in keeping up to date. This NATO Advanced Study Institute (ASI) was organized with the objective of overcoming the information barrier between those expert in the field and those who are new to it. Thus it was decided to (i) organize a set of tutorially based lectures covering most of the important facets in the field, and (ii) to produce an Institute proceedings which would serve both as the first general textbook, as well as a valuable reference book, for this field of knowledge.

The borderline of quantum electrodynamics and quantum optics offer spectacular results and problems concerning the foundations of radiation theory. Perhaps the major new viewpoint that has emerged from recent investigations is that one can now work inside a time-dependent quantum process, whereas up to now all elementary quantum processes were either stationary, or one worked with asymptotic in-and out-states, i.e. an S-matrix approach. In the-rirst part of this volume, the Quantum Electrodynamics, the present status of the main approaches to this most accurate of all physical theories are discussed: the Hamiltonian approach, the Green's function approach with particular emphasis to bound state problems, and the newer, nonperturbative approach. The latest numerical results on radiative corrections, Lamb shifts and anomalous magnetic moments are reviewed with new results for high Z atoms. Also discussed are different theoretical interpretations of the radiative phenomena as due to quantized field vacuum fluctuations or due to self energy. A small group of contributions are devoted to the physics and mathematical description of decaying or unstable states in quantum theory. This remarkable phenomenon of quantum theory still needs complete clarification, it is a time-dependent phenomenon, which can be described also by asymptotic S-matrix methods, but with complex energies.

The 1982 Antwerp Advanced Study Institute on "Physics of Polarons and Excitons in Polar Semiconductors and Ionic Crystals" took place from July 26 till August 5 at the Conference Center Priorij Corsen­ donk, a restored monastery, close to the city of Antwerp. It was the seventh Institute in our series which started in 1971. This Advanced Study Institute, which was held fifty years after Landau introduced the polaron concept, can be considered as the third major international symposium devoted to the physics of pola­ rons. The first such symposium took place in St. Andrews in 1962 under the title "Polarons and Excitons" [I]. The early theoretical developments related to polarons were reviewed in depth at this meeting; the derivation of the polaron hamiltonian by Frohlich, the Frohlich weak coupling theory (and the equivalent weak coupling canonical transformations), the Landau-Pekar and Bogolubov strong coupling theory and the Feynman polaron model formulated with his path integrals. The main emphasis was on the polaron self-energy, effective mass and mobility. From the experimental side the first evidence for polaron effects was provided by the pioneering cyclotron and mobility measurements o~ the silver halides by F. e. Brown and his group. Also the significance of polaron effects for the under­ standing of excitons in ionic crystals was a central topic in St. Andrews. The second Advanced Study Institute concerning polaron physics was organized at the University of Antwerp (R. U. C. A.

The need for long-term energy sources, in particular for our highly technological society, has become increasingly apparent during the last decade. One of these sources, of tremendous poten­ tial importance, is controlled thermonuclear fusion. The goal of controlled thermonuclear fusion research is to produce a high-temperature, completely ionized plasma in which the nuclei of two hydrogen isotopes, deuterium and tritium, undergo enough fusion reactions so that the nuclear energy released by these fusion reactions can be transformed into heat and electricity with an overall gain in energy. This requires average kinetic energies for the nuclei of the order of 10 keV, corresponding to temperatures of about 100 million degrees. Moreover, the plasma must remain confined for a certain time interval, during which sufficient energy must be produced to heat the plasma, overcome the energy losses and supply heat to the power station. At present, two main approaches are being investigated to achieve these objectives: magnetic confinement and inertial con­ finement. In magnetic confinement research, a low-density plasma is heated by electric currents, assisted by additional heating methods such as radio-frequency heating or neutral beam injection, and the confinement is achieved by using various magnetic field configurations. Examples of these are the plasmas produced in stellarator and tokamak devices.

The Advanced Study Institute on "Advances in Superconductivity" was held at the Ettore Majorana Centre for Scientific Culture in Erice, Sicily, during July 3 to July 15, 1982. This Institute was the third course of the International School of Low Tempera­ ture Physics, which was established at the Centre in 1977 with the guidance and inspiration of T. Regge and A. Zichichi. The 1982 Course was centered on a topic which brought together fundamental basic research and the most recent promising technological applications. Accordingly, the participants represented a wide spectrum of industrial and government laboratories, as well as universities from various countries. The program of topics and speakers was developed with the advice of the Organizing Committee, composed of H. Frohlich, T. Regge, B. Stritzker, and L. Testardi. This Institute emphasized recent developments in the science and technology of superconductivity. A historical perspective was provided by H. Frohlich, whose lectures recall the earliest discoveries and theoretical attempts to understand superconductivity. Ironically, his early suggestion of the electron-phonon coupling as a key to superconductivity was met with initial widespread skepticism. Later, the development of field theory methods for solid state physics problems, and the evolution of the BCS theory has led to a seemingly unanimous concensus regarding the e1ectron­ phonon mechanism as the predominant source of superconductivity in known materials. Experimental studies of superconductivity exemplify the strong interplay of science and technology in many ways.

The present volume contains contributions presented at the NATO Advanced Study Institute on Molecular Ions held on the island of Kos, Greece, from September 30 to October 10, 1980. The meeting was attended by some 60 participants from 15 different countries. It was the first meeting devoted exclusively to the topic of molecular ions. Its vitality derived from bringing together experts and students from a wide variety of disciplines, whose studies bear upon the structure of molecular ions. The aim of the meeting was to assemble these scientists, representing many countries in Europe and North America, to discuss the advances and capabilities of the various experimental and theoretical approaches and to point out un­ solved problems and directions for future research. The format, in­ volving lecturers and students, served as a tutorial. Molecular ions play an important role in very diverse fields of nature such as reactions in the ionosphere, the processes of forma­ tion of molecules in dense interstellar clouds, and the magnetohydro­ dynamics of plasmas used for energy generation. Our understanding of the properties of molecular ions, their electronic and geometric structures, has been developing from a variety of sources, as far removed as tickling ions with radiofre­ quency radiation and smashing them apart at relativistic energies. Various laser techniques are described, and the queen of structural determination, spectroscopy, is well represented. On the instrumen­ tal side, older techniques have been perfected and new methods have evolved.

This volume contains the proceedings of a two-week NATO A.S.I. on Integrated Optics: Physics and Applications, held from August 17 to August 30, 1981 in Erice, Italy. This is the 8th annual Course of the "International School of Quantum Electronics" presented under the auspices of the "E. Majorana" Centre for Scientific Culture. The subject was chosen in order to satisfy the demand for a course on integrated optics which is relevant to the expanding use of fiber optics for communication and signal processing. Integrated Optics, encompassing all of the optical waveguide circuits which are the optical analog of integrated circuits, is finding its way into a variety of applications involving communi­ cations, high speed signal-processing, and sensors of many kinds. However, because the technology is still changing very rapidly, the development of these exciting applications relies heavily upon the physics of the integrated optical circuits themselves and the pro­ cessing techniques used to fabricate them. This NATO A.S.I. provided not only a thorough tutorial treatment of the field, but also through panel discussions and additional lectures treated topics at the forefront of present work. Therefore the character of the Course was a blend of current research and tutorial reviews. "The Physics and Applications of Integrated Optics" could hardly be a more appropriate title to be chosen for this volume. Many of the worlds' acknowledged leaders in the field have been brought together to review and speculate on the accomplishments of integrated optics.

The Advanced Study Institute on "Quantum Dynamics of Molecules: The New Experimental Challenge to Theorists," which was sponsored by the Scientific Affairs Division of NATO, was held at Trinity Hall, Ca~bridge, England from September 15th till September 29th, 1979. In all, a total of 79 lecturers and students attended the meeting: they had diverse backgrounds in chemistry, physics and mathematics. In my proposal to NATO requesting financial support for an Advanced Study Institute, I suggested that molecular physics was facing a qualitatively new experimental situation in which the exploration of previously inaccessible dynamical phenomena would become of increasing importance. At the same time I was aware that in recent years powerful theoretical techniques, that might prove crucial tools for the interpretation of the new experiments, have been developed in mathematics and theoretical physics. The aim of the ASI was to review at an advanced level these recent developments, juxtaposing new theory with new experimental pos­ sibilities in the hope that the participants in the-Institute would through their subsequent work increase the awareness of the whole molecular theory community of the changing nature of chemical physics. The recent developments in laser spectroscopy, particle scatter­ ing experiments and molecular beam technology imply that an entirely new class of phenomena involving molecules in gasses and liquids can now be investigated.

The Advanced Study Institute on Strongly Coupled Plasmas was held on the campus of the Universite d'Orleans, Orleans-la-Source, France, from July 6th through July 23rd, 1977. 15 invited lecturers and 50 other participants attended the Institute. The present Volume contains the texts of most of the lectures and of some of the numerous seminars presented at the Institute. The topic of strongly coupled coulomb-systems has been an area of vigorous activities over the last few years. Such systems occur in a great variety of physical situations: stellar and planetary interiors, solid and liquid metals, semiconductors, laser compressed plasmas and gas discharges are some of the most important examples. All these systems have the common feature that for one or more of their constituent charged particle liquids the potential energy to kinetic energy ratio is not small, and therefore the application of the traditional plasma perturbation techniques is not feasible. Many ingenious theoretical schemes have been worked out in order to attack both the related equilibrium and nonequilibrium problems, and also various methods have been borrowed from areas where problems not dissimilar to the ones arising in coulomb-systems had already been tackled. At the same time, computer simulations have led to a probably unparalleled accumulation of data on the behavior of an ensemble of classical charged particles. For the first time, the Institute assembled workers from various disciplines who had been involved with diverse aspects of the strongly coupled plasma problem.

The 1986 Advanced Study Institute on "The Physics of the two-Dimen sional Electron Gas" took place at the Conference Centre liTer Helme", close to Oostende (Belgium), from June 2 till 16, 1986.

The 1981 Cargese Summer Institute on Fundamental Interactions was organized by the Universite Pierre et Marie Curie, Paris (M. It was the 24th Summer Institute held at Cargese and the 8th one organized by the two institutes of theoretical physics at Leuven and Louvain-Ia-Neuve.

The NATO ADVANCED SUMMER INSTITUTE ON THEORETICAL PHYSICS 1981 st was held in Freiburg, Germany from August 31 until September 11th 1981. It was the twelfth in a series of Summer Institutes organized by German Universities. Its main objective was a thorough comparison of structures and methods of two different branches of Theoretical Physics, name­ ly Elementary Particle Physics and Statistical Mechanics, and the idea was to exhibit the structural similarities, to trace them until their origins, to compare solution and approximation schemes and to report on those new results and methods in either of the two branches which are indicative of an intimate connection between them. Thus stimulation of a deeper understanding and development of new Methods could be hoped for in both fields. The contributions to the Summer Institute - lectures and seminars - are contained in this volume. One group of them gives concise up-to-date information on basic topics in Statistical Mechanics and Phase Transitions, Dynamical Systems, Solvable Lattice Models and Lattice Gauge The­ ories. A second group is devoted to special topics which illustrate the interrelationship between Statistical Mechanics and Elementary Particle Physics, like topological quantum numbers on a lattice, model studies on the confinement problem, etc. Supplementary information on experimental implications and on neighbouring fields is provided in a third group.

This volume contains the lectures and communications presented at the NATO Advanced Research Workshop on "Atomic and Molecular Processes with Short Intense Laser Pulses" (NATO ARW 848/86). The workshop was held at Bishop's University, Lennoxville, Que, Canada, July 19-24, 1987, under the directorship of Prof. A.D. Bandrauk, Universite de Sherbrooke. A scientific committee made up of Dr. P. Corkum (Laser Physics, ~ational Research Council of Canada), Dr. P. Hackett (Laser Chemistry, National Research Council of Canada), Prof. S.C. Wallace (Dept. of Chemistry and Physics, University of Toronto), and Prof. F.H.M. Faisal (FakultHt fUr Physik, UniversitHt Bellefeld) was called upon to invite and organize eminent lectures in the fields of i) Coherence Phenomena in Atomic and Molecular Photoprocesses. ii) High Intensity Atomic and Molecular Phenomena. iii) Laser Chemistry The aim of the workshop was to bring together chemists and physicists in order to~iscuss and analyze the progress made in the use of short in­ tense laser pulses in understanding coherence phenomena and high intensity, nonlin~adiative effects in atomic and molecular systems.

The first instruments to expand the observational range of the human eye were simple optical systems, designed in the case of microscopes and telescopes to magnify the image.

However, the emphasis was still on collision-induced absorption in compressed gases, although some work on liquids, solid H , and related subjects such as ro 2 tational relaxation was included.

The solid, liquid, and gaseous states are ordinary states, but the fourth state of matter, the plasma state, has retained a somewhat extraordinary character. The study of matter in the ionized state comprises a large diversity of problems belonging to many different branches of phys ics.

This book has its or1g1n in a NATO Summer School organized from June 25 to July 7 1979, in Menton, France. The need of putting together these lectures, in the form of a monograph, clearly appeared during the ASI and the lecturers accepted to write down the material they presented at the Institute, improved thanks to the remarks of the participants.

The Advanced Study Institute on "Quantum Dynamics of Molecules: The New Experimental Challenge to Theorists," which was sponsored by the Scientific Affairs Division of NATO, was held at Trinity Hall, Ca~bridge, England from September 15th till September 29th, 1979.

The interest of describing the ground state properties of a system in terms of one electron density (or its two spin components) is obvious, in particular due to the simple physical significance of this function.

The present volume contains contributions presented at the NATO Advanced Study Institute on Molecular Ions held on the island of Kos, Greece, from September 30 to October 10, 1980.

Integrated Optics, encompassing all of the optical waveguide circuits which are the optical analog of integrated circuits, is finding its way into a variety of applications involving communi cations, high speed signal-processing, and sensors of many kinds.

The Advanced Study Institute on Strongly Coupled Plasmas was held on the campus of the Universite d'Orleans, Orleans-la-Source, France, from July 6th through July 23rd, 1977. For the first time, the Institute assembled workers from various disciplines who had been involved with diverse aspects of the strongly coupled plasma problem.

Volume 5 of Advances in Nutritional Research reflects a strong current interest in the relationship between nutrition and disease. The impact of disease on nutritional status is described for hepatic encephalopathy and cancer and for several ailments of hospitalized children. The impact of nutrition on disease is illustrated using the examples of retinol in tumorigenesis, vitamins A and E in inflammatory lung disease, fatty acids in atherogenesis and obesity, and folate in megaloblastic anemia. The contents will be of particular interest to clinicians and to students of nutritional biochemistry. vii Contents Chapter 1. Nutritional Management of Hepatic Encephalopathy ...Robert H. Bower and Josef E. Fischer 1. Introduction ...1 2. The Nature of Hepatic Encephalopathy...2 2.1. The Ammonia Concept ...2 2.2. The Amino Acid Neurotransmitter Concept...3 3. Nutritional Support in Hepatic Insufficiency...6 3. 1. Therapeutic Implications ...6 3.2. Therapeutic Options...6 4. Experiments in Animals...7 5. Experience with Patients in Hepatic Encephalopathy ...7 5.1. Acute Hepatic Encephalopathy ...7 5.2. Chronic Hepatic Encephalopathy...9 References ...9 Chapter 2.Cellular Retinol-and Retinoic Acid-Binding Proteins...13 Frank Chytil and David E. Ong 1 . Introduction ...13 ...2. Cellular Retinol-and Retinoic Acid-Binding Proteins ...13 . 2.1. Detection ...14 ...2.2. Characteristics ...15 ...3. Binding Proteins in Cultured Cells ...19 ...4. Binding Proteins in Tumors...23 ...4.1. Binding Proteins in Experimental Tumors ...23 ...4.2. Binding Proteins in Human Tumors ...23 ...References ...26 ...ix x Contents Chapter 3. Nutrition and 3-Methylindole-lnduced Lung Injury ...31 ...

The borderline of quantum electrodynamics and quantum optics offer spectacular results and problems concerning the foundations of radiation theory.

However, the emphasis was still on collision-induced absorption in compressed gases, although some work on liquids, solid H , and related subjects such as ro 2 tational relaxation was included.

Over the past two decades much more, and much more detailed, information on phonon transport and on many of the inherent phonon interaction processes have come to light from experiments which use nonequilibrium phonons to study their dynamics.

The first instruments to expand the observational range of the human eye were simple optical systems, designed in the case of microscopes and telescopes to magnify the image.