DNA Adducts

This is the first and only handbook to provide a comprehensive review of the critical intermediates in the first step of the process of carcinogenesis. This volume reviews current knowledge of DNA adducts formed by a wide range of classes of chemical compound, including the metabolism of chemicals, mechanisms of adduction, preparation and properties of standard compounds, adduct formation in vitro, measurements of adducts in humans, and biological significance. Additional chapters review our understanding of specific types of gene damage and mutagenecity and their reaction to cancer. This volume will provide invaluable, up-to-date facts for all researchers in mechanism of carcinogenesis, toxicology, and molecular epidemiology.