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Fermented Cholesterol Lowering Drug (Lovastatin)

Fermented Cholesterol Lowering Drug (Lovastatin)af Sadia Javed
Bag om Fermented Cholesterol Lowering Drug (Lovastatin)

Lovastatin is an inhibitor of 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate. In western countries, the most significant cause of death is the coronary heart disease and progression of atherosclerosis which is mostly related to the hypercholesterolemia. Approximately 10.8% of all deaths are caused due to this disease. Coronary heart disease actually is a wide assortment of diseases. It has been reported that 30 million people have familial hypercholesterolemia worldwide, but less than 1% of cases are diagnosed in most countries. A lab experiment was carried out for fungal production of lovastatin in solid state fermentation. Fermentation medium was optimized by optimizing the fermentation parameters (pH, temperature, inoculum size, moisture contents etc.).

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  • Sprog:
  • Engelsk
  • ISBN:
  • 9783845475158
  • Indbinding:
  • Paperback
  • Sideantal:
  • 104
  • Udgivet:
  • 10. oktober 2013
  • Størrelse:
  • 150x7x220 mm.
  • Vægt:
  • 173 g.
  • BLACK NOVEMBER
Leveringstid: 2-3 uger
Forventet levering: 29. november 2024

Beskrivelse af Fermented Cholesterol Lowering Drug (Lovastatin)

Lovastatin is an inhibitor of 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate. In western countries, the most significant cause of death is the coronary heart disease and progression of atherosclerosis which is mostly related to the hypercholesterolemia. Approximately 10.8% of all deaths are caused due to this disease. Coronary heart disease actually is a wide assortment of diseases. It has been reported that 30 million people have familial hypercholesterolemia worldwide, but less than 1% of cases are diagnosed in most countries. A lab experiment was carried out for fungal production of lovastatin in solid state fermentation. Fermentation medium was optimized by optimizing the fermentation parameters (pH, temperature, inoculum size, moisture contents etc.).

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