Bøger af International Agency for Research on Cancer

PLEASE NOTE: Text has been accidentally deleted frompage 54 of this book. Please refer to the corrigenda (PDF file) posted on the Stylus Publishing web site or email stylusinfo@styluspub.com for an updated, printable page. ****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.***** Soft Tissue and Bone Tumours is the third volume in the 5th edition ofthe WHO series on the classification of human tumors. This series (also knownas the WHO Blue Books) is regarded as the gold standard for the diagnosis oftumors and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise referencebooks provide indispensable international standards for anyone involved in thecare of patients with cancer or in cancer research, underpinning individualpatient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education. This volume will be of particular interest to pathologists, oncologists, surgeons, and epidemiologists who manage or research soft tissue and bonetumors. Sections are included on all recognized neoplasms of the soft tissueand bone, as well as on genetic tumor syndromes affecting these sites. Sincethe previous edition, there have been changes based on recent molecular andgenetic information, with impact on clinical practice.

This is the first and only handbook to provide a comprehensive review of the critical intermediates in the first step of the process of carcinogenesis. This volume reviews current knowledge of DNA adducts formed by a wide range of classes of chemical compound, including the metabolism of chemicals, mechanisms of adduction, preparation and properties of standard compounds, adduct formation in vitro, measurements of adducts in humans, and biological significance. Additional chapters review our understanding of specific types of gene damage and mutagenecity and their reaction to cancer. This volume will provide invaluable, up-to-date facts for all researchers in mechanism of carcinogenesis, toxicology, and molecular epidemiology.

****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.*****WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues is a Revised Fourth Edition of the WHO series on histological and genetic typing of human tumors. This authoritative, concise reference provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants further include new ICD-O codes, epidemiology, clinical features, macroscopy, prognosis, and predictive factors. This classification, prepared by 132 authors from 23 countries, contains about 1300 color images and tables and more than 4500 references.

Records 22 papers presented at a meeting concerned with the design of prospective studies to investigate the role of diet and hormones in the etiology of cancer. The objective of the meeting was to identify methodological differences and common elements in both on-going and planned studies in order to facilitate the consolidation of data, communicate practical lessons about the advantages and pitfalls of different methodological approaches, and avoid duplication of efforts. Papers are presented in four main parts. The first describes on-going or planned prospective studies on diet and cancer at centres in the USA, Holland, Italy, France, Finland, Sweden, Denmark, and Poland. Papers in the second section, devoted to dietary assessment methods for epidemiological studies, communicate experiences in the use of dietary questionnaires and in methods for attenuating the problem of measurement error in nutritional epidemiology. Methodological problems in the use of biochemical, anthropometric and other measures of diet and nutritional status are considered in the third section. The book concludes with papers describing four prospective studies designed to determine the link between endogenous and exogenous hormones and cancers of the breast and female reproductive organs.

Evaluates the carcinogenic risks to humans posed by exposure to crystalline and amorphous silica, some silicates (palygorskite, sepiolite, wollastonite, and zeolites other than erionite), coal dust, and para-aramid fibrils. The volume opens with a discussion of the many complexities involved in assessing the cancer risks associated with occupational exposure to inhaled mineral dusts, and the special toxicological considerations required when evaluating the results of experimental studies. Against this background, the first and most extensive monograph evaluates human and animal carcinogenicity data on silica, concentrating on evidence of an increased risk for lung cancer. On the basis of this evaluation, crystalline silica inhaled in the form of quartz or cristobalite from occupational sources was classified as carcinogenic to humans. For amorphous silica, evidence from both epidemiological and experimental studies was judged inadequate, and amorphous silica could not be classified. For palygorskite, the evaluation found sufficient evidence from studies in rats that long fibres were carcinogenic; studies of exposure to short fibres showed no significant increase in the incidence of tumours. The few studies in humans were judged inadequate. Long palygorskite fibres were classified as possibly carcinogenic to humans. Short fibres could not be classified. For coal dust, several limitations in human studies, largely concerned with excessive mortality from lung and stomach cancer, hindered interpretation of the epidemiological literature. The few adequate experimental studies showed no increase in tumours. Coal dust therefore could not be classified. para-Aramid fibrils likewise could not be classifed in view of inadequates in both the epidemiological and experimental data.