Bøger af Vivek Mishra

Nanotherapeutics for Inflammatory Arthritis: Design, Diagnosis, and Treatment highlights nanobiotechnology and its therapeutic applications in the field of inflammatory arthritis, the interaction of nanomaterials in the biological systems, and clinical development of nanomedicines. It also covers the discovery of personalized therapeutics, diagnostics, and nanoparticular delivery systems, the role of bioinformatics nanobiotechnology in personalized oncology. The use of nanosensors for the detection and current challenges in the development of personalized medicine is explained including recent nanotechnology-based strategies.Features: Covers all the fundamental information about nanotechnology and inflammatory arthritis. Highlights the interaction of nanomaterials in the biological systems, and the clinical development of nanomedicines for inflammatory arthritis. Explores discovery of personalized therapeutics, diagnostics, and nanoparticle delivery systems. Reviews current challenges in the development of personalized medicine as well as translation of nanomedicine with combination therapy. Discusses toxicology of using nanomedicines and the risks associated with the use of these nanomedicines. This book is aimed at researchers and professionals in nanotechnology, biomaterial, drug delivery, and inflammatory arthritis.

Beginning Apache Cassandra Development introduces you to one of the most robust and best-performing NoSQL database platforms on the planet. Apache Cassandra is a document database following the JSON document model. It is specifically designed to manage large amounts of data across many commodity servers without there being any single point of failure. This design approach makes Apache Cassandra a robust and easy-to-implement platform when high availability is needed.Apache Cassandra can be used by developers in Java, PHP, Python, and JavaScript—the primary and most commonly used languages. In Beginning Apache Cassandra Development, author and Cassandra expert Vivek Mishra takes you through using Apache Cassandra from each of these primary languages. Mishra also covers the Cassandra Query Language (CQL), the Apache Cassandra analog to SQL. You'll learn to develop applications sourcing data from Cassandra, query that data, and deliver it at speed to your application's users.Cassandra is one of the leading NoSQL databases, meaning you get unparalleled throughput and performance without the sort of processing overhead that comes with traditional proprietary databases. Beginning Apache Cassandra Development will therefore help you create applications that generate search results quickly, stand up to high levels of demand, scale as your user base grows, ensure operational simplicity, and—not least—provide delightful user experiences.

Since AO and BY has been shown to be indiscriminately added in food and oil and both have genotoxic and carcinogenic/mutagenic potential. Hence, following studies are proposed as a part of this dissertation to fill up the above mentioned lacuna in argemone oil and butter yellow intoxication. Reproductive toxicity: Consumption of edible oil adulterated with argemone oil (AO) is also presumed to be one of the factors for reduction in sperm count and we have observed that alterations in germ cell apoptosis by a disruption in contact mediated communication between the Sertoli cells and germ cells, may subsequently lead to testicular impairment. Hepatic Toxicity: The study suggests that AO and BY treatment may cause oxidative stress and diminished phase I & II enzymes leading to accumulation of parent compound (s) or their metabolites which may results in the formation of liver cancer. Carcinogenic potential in gall bladder in vitro and in vivo study suggests that AO and BY are responsible for producing gall bladder carcinoma in mice along with stone formation in AO exposure.

The objective of this study was to understand the pitfalls of the poor oocyte cleavage and subsequent embryo production by assessing the developmental competence of the oocytes in buffalo using parthenogenesis as a model which was compared with IVF (natural activation). Buffalo ovaries were collected from slaughter house and matured oocytes were subjected to either IVF (control) or chemical activation (treatment)[7% ethanol (ET)for 7 min + 2.5 mM 6-Di methyl amino purine (6-DMAP) for 4 hr, or 7% ET for 7 min + 10 ug/ml Cycloheximide (CHX) for 6 hr or 7% ET for 7 min + 2.5 mM 6-DMAP + 10 ug/ml CHX for 6 hr]. Fertilized and chemically activated oocytes were cultured in mSOF medium for 8 days to study embryo development.In conclusion, the results of parthenogenesis, revealed that buffalo oocytes had better inherent developmental competence and the poor cleavage and embryo development following IVF, in our study, may partly be due to the poor quality of frozen-thawed sperm, improper sperm capacitation and/ or fertilization. Further, high ambient temperature adversely affected the cleavage and embryo development following IVF.