Bøger udgivet af Morgan & Claypool Publishers

Takes the reader on an incredible journey to explore the exciting discoveries in genetics and molecular biology. The reader will embark on a genetic odyssey starting with the "Father of Genetics", Gregor Mendel, leading on to the story of photo 51 and the discovery of the structure of the DNA double helix, and culminating with the invention of the polymerase chain reaction.

Provides an overview of angiogenesis processes and discusses the importance of VEGF-C and VEGF-D precursors processing by the proprotein convertases during the activation of VEGFR-2 and VEGFR-3 receptors and the mediation of their functions during angiogenesis, lymphangiogenesis, and tumorigenesis.

Necrotizing enterocolitis is an acute inflammatory necrosis of bowel that primarily afflicts premature infants in the neonatal intensive care unit setting. Although patients who develop this disease have high morbidity and mortality rates, the pathogenesis is poorly understood. This title discusses new approaches based on sound evidence.

One of the major scientific thrusts in recent years has been to try to harness quantum phenomena to increase dramatically the performance of a wide variety of classical information processing devices. In particular, it is generally accepted that quantum computers and communication systems promise to revolutionize our information infrastructure.

Introduces advanced concepts and topics of solid-state theory. To this end a tool box that enables us to treat electron-electron interactions, and possibly also electron-phonon or phonon-phonon interactions in some well-defined, approximate way. The most advanced, yet still feasible approach, is the Green's function technique and the perturbation expansion using Feynman diagrams.

Provides a fresh, photon-based description of modern molecular spectroscopy and photophysics, with applications drawn from chemistry, biology, physics and materials science. The concise and detailed approach includes some of the most recent developments, dispensing with old-fashioned treatments of theory and instrumentation.

Weights and measures form an essential part of our ingrained view of the world. It is just about impossible to function effectively without some internalized system of measurement. This volume outlines a history of the science of measurement, and the origin of the International System of Units (SI).

Nonlinear physics is a well-established discipline in physics today. This book offers a comprehensive account of the basic soliton theory and its applications. It addresses mathematical theories, but also suggests possible theoretical innovations for many issues, providing a stimulating reference for both students and researchers.

"Buckyball, onion, nanobud, peapod - what are these buzzwords about?" This concise glossary is designed to provide the first answer to these and similar questions, and be a guide through the jungle of the jargon that has evolved in the busy field of carbon nanostructures.

Describes the general structure of G protein-coupled receptors, including the information obtained from crystal structure determination that has given an insight into the activation mechanism of these receptors. In addition, the book summarizes the components of the signal transduction system (including G proteins, effectors and second messengers generally activated by the neuropeptide receptors).

Provides a history of the early studies linking immune system function with hypertension and an overview of the large number of studies published in the past decade. The major focus is on the components of the innate and adaptive immune systems for which there is considerable evidence of their contributions to blood pressure control.

The gastrointestinal mucosal defense system serves to minimize mucosal injury by either ingested or endogenously produced noxious substances. However, there are two situations in which the mucosal defense system is known to be ineffective and result in gastric mucosal injury: inadvertent ingestion of H. pylori. or intentional ingestion of NSAIDs.

The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.

Several physiological mechanisms act to regulate renal potassium excretion and distribution. Together they comprise an integrated control system that may be envisioned as being made up of several interacting negative feedback control mechanisms. The intent of this volume is to describe the mechanisms of potassium regulation.

Provides a review of the general principles of Ca2+ signal transduction and examples of some of the major Ca2+-dependent cellular processes. This volume also reviews the main sources of Ca2+ and the molecular effectors of Ca2+ signals, and provides some examples from the literature that illustrate how Ca2+ signalling works.

The concept of vesicular traffic as a means of protein transport in and out of cells and between membrane compartments has been established since the 1960s. This volume introduces mechanisms of vesicle sculpting, cargo selection, vesicle targeting, and vesicle consumption that have emerged as common characteristics of multiple transport steps in the exocytic and endocytic pathways.

The control of breathing during exercise remains the source of considerable debate. Classical schemes of the exercise hyperpnea have incorporated elements of proportional feed-back from chemoreceptor sites and feed-forward neurogenic control. However, the precise details of the control process are still not fully resolved.

Edmund C. Berkeley (1909-1988) was a mathematician, insurance actuary, inventor, publisher, and a founder of the Association for Computing Machinery. This biography, based on primary sources, provides a lens to understand social and political decisions surrounding early computer development, and the consequences of these decisions in our 21st century lives.

Examines the forces of nature, and what investigations of these forces can tell us about the world we see about us. The intention of this book is to introduce ideas of how the visible world, and those parts of it that we cannot observe, either because they are too small or too large for our scale of perception, can be understood by consideration of only a few fundamental forces.

This book is a concise introduction to the key concepts of classical field theory for beginning graduate students and advanced undergraduate students who wish to study the unifying structures and physical insights provided by classical field theory without dealing with the additional complication of quantization. In that regard, there are many important aspects of field theory that can be understood without quantizing the fields. These include the action formulation, Galilean and relativistic invariance, traveling and standing waves, spin angular momentum, gauge invariance, subsidiary conditions, fluctuations, spinor and vector fields, conservation laws and symmetries, and the Higgs mechanism, all of which are often treated briefly in a course on quantum field theory.

The Transmission Electron Microscope (TEM) is the ultimate tool to see and measure structures on the nanoscale and to probe their elemental composition and electronic structure with sub-nanometer spatial resolution. This book is a practical guide for scientists who need to use the TEM as a tool to answer questions about physical and chemical phenomena on the nanoscale.

The study of dark matter, in both astrophysics and particle physics, has emerged as one of the most active and exciting topics of research in recent years. This book reviews the history behind the discovery of missing mass (or unseen mass) in the Universe, and ties this into the proposed extensions to the Standard Model of Particle Physics (such as Supersymmetry), which were being proposed within the same time frame. This book is written as an introduction to these problems at the forefront of astrophysics and particle physics, with the goal of conveying the physics of dark matter to beginning undergraduate majors in scientific fields. The book goes onto describe existing and upcoming experiments and techniques, which will be used to detect dark matter either directly on indirectly.

This book provides a theoretical background in computation to scientists who use computational methods. It explains how computing is used in the natural sciences, and provides a high-level overview of those aspects of computer science and software engineering that are most relevant for computational science.

This book describes modern focused ion beam microscopes and techniques and how they can be used to aid materials metrology and as tools for the fabrication of devices that in turn are used in many other aspects of fundamental metrology. Beginning with a description of the currently available instruments including the new addition to the field of plasma-based sources, it then gives an overview of ion solid interactions and how the different types of instrument can be applied. Chapters then describe how these machines can be applied to the field of materials science and device fabrication giving examples of recent and current activity in both these areas.

Provides an overall review of all non-peptide PCSK inhibitors so far reported in the literature along with those identified recently for the first time and not yet published. The potential implications of these molecules as biochemical, therapeutical, or clinical agents is also discussed.