Methotrexate

Methotrexate: historical aspects.- Methotrexate, its mechanisms of action in malignant disease and mechanisms of resistance by malignant cells.- Current use of methotrexate in the treatment of malignancies in adults.- The use of methotrexate in the treatment of childhood malignancies.- The mechanisms of methotrexate's action in the treatment of inflammatory disease.- Methotrexate in rheumatoid arthritis.- Use of methotrexate in the treatment of psoriasis and other dermatological disorders.- The use of methotrexate in gynecological practice.