Study of Few Tetralone Analogs

In the recent past tetralone have aroused great interest in the field of drug discovery owing to their wide applications as analgesic, antidepressant, antifungal and antibacterial. It is an ubiquitous structural feature of many alkaloid natural products and viable drug candidates. Pharmacological effect of potential drugs depends sensitively on the stereochemistry and ring conformation especially in the case of 4 substituted tetralone. Antidepressants are drugs which can elevate mood in depressive illness. Practically all depressants affect monoaminergic transmission in the brain. Tricyclic antidepressants (TCAs) are a group of drugs used to treat affective, or ¿mood¿, disorders. Mood disorders are associated with reduced levels of monoamines in the brain. TCA binding to 5-HT and noradrenaline re-uptake transporters prevents the re-uptake of these monoamines from the synaptic cleft and their subsequent degradation. This re-uptake blockade leads to the accumulation of 5-HT and noradrenaline in the synaptic cleft and the concentration returns to within the normal range