Oxidative Stress: Physiopathology and Clinical Aspects

Oxidative stress is a disturbance in the balance between the production of reactive oxygen species and antioxidant defenses. Disruptions in the normal redox state of cells can lead to damage of cell components such as lipids, proteins and DNA. Oxidative stress and cellular senescence are involved in several acute and chronic pathological conditions, such as acute and chronic kidney disease, cardiovascular diseases, biliary diseases and macular degeneration. Some of the major diseases that can be traced back to oxidative stress include Alzheimer's disease, Parkinson's disease, myocardial infarction, atherosclerosis, sickle-cell disease, ADHD, etc. The reactive species formed due to oxidative stress can cause damage to DNA, suppress apoptosis, and promote proliferation, metastasis and invasiveness. These are important processes in the development of cancer. This book covers in detail some existing theories and innovative concepts revolving around oxidative stress. The topics covered herein deal with the physiopathology and clinical aspects of oxidative stress. With state-of-the-art inputs by acclaimed experts of this field, this book targets students and professionals.