Relevance to Human Cancer of N-Nitroso Compounds, Tobacco Smoke and Mycotoxins

The etiology and prevention of common human cancers are the subjects of the reviews and previously unpublished research presented in this volume arising from a multidisciplinary symposium on n-nitroso compounds, tobacco and mycotoxins. Although tobacco smoking and chewing have long been established as risk factors, the possible role of nitroso compounds has inspired extensive research. The 110 papers on these three classes of carcinogenic agents cover epidemiological updates, exposures and biological monitoring, exposure prevention and dietary anti-carcinogens, and biological mechanisms and effects. The volume includes many studies of these issues from the People's Republic of China. The relevance of this work is highlighted by the fact that the cancer sites causally or putatively associated with these exposures (liver, respiratory and alimentary tracts) are those at highest risk in developed and developing nations.